Presented By: Office of Research School of Dentistry
Limb synovial joint development and morphogenesis: progress and mysteries
Maurizio Pacifici, PhD Director of Orthopaedic Research Childrens Hospital of Philadelphia
Studies in my lab focus on mechanisms regulating limb synovial joint formation, skeletal development and growth plate function and involving signaling proteins, cell surface receptors and co-receptors and transcription factors. Data and insights from these basic research projects are used to decipher the pathogenesis of congenital pediatric musculoskeletal disorders and identify possible therapeutic remedies.
Disorders under active study at present are Hereditary Multiple Exostoses (HME), Achondroplasia and Fibrodysplasia Ossificans Progressiva (FOP). This basic-translational-clinical strategy is proving fruitful as one drug identified in my lab for the treatment of FOP was recently approved in Canada, with approval in the US expected soon. I am the Director of Pediatric Orthopaedic Research here at the Children’s Hospital of Philadelphia (CHOP) and have served in this position since 2011. I am also the Associate Director of the Penn Center for Musculoskeletal Diseases (PCMD) at U Penn that has over 15 faculty members and maintains 3 Research Cores, serving a large biomedical research community at our two adjacent Institutions and surrounding Universities and Research Institutes.
Disorders under active study at present are Hereditary Multiple Exostoses (HME), Achondroplasia and Fibrodysplasia Ossificans Progressiva (FOP). This basic-translational-clinical strategy is proving fruitful as one drug identified in my lab for the treatment of FOP was recently approved in Canada, with approval in the US expected soon. I am the Director of Pediatric Orthopaedic Research here at the Children’s Hospital of Philadelphia (CHOP) and have served in this position since 2011. I am also the Associate Director of the Penn Center for Musculoskeletal Diseases (PCMD) at U Penn that has over 15 faculty members and maintains 3 Research Cores, serving a large biomedical research community at our two adjacent Institutions and surrounding Universities and Research Institutes.
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