This noontime talk features Sally Okun, RN, MMHS, a member of the Research and Development team at PatientLikeMe, Inc since 2008. Increasingly, people are using social media to meet others with their same condition and to exchange information about symptoms, treatments and side effects. Peer-to-peer online networks are an emerging source for a new generation of patient-reported data. Since few websites collect these data in a scientific manner, patient experience and knowledge are too often lost. PatientsLikeMe, a patient-powered research network, harnesses the unique characteristics of patient insight by capturing data that matters to patients using clinically relevant patient-reported outcome measures (PRO). This presentation will explore what we have learned from PROs about how diseases and treatments act in the real world; validate the impact of PROs on care and decision-making; and establish PROs as essential to a continuously learning 21st century health system.