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DTSTAMP:20260423T091242
DTSTART;TZID=America/Detroit:20260427T110000
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SUMMARY:Workshop / Seminar:MCDB Master's Thesis Defense Seminar> An in vivo model for mammary-specific claudin 7 knockout
DESCRIPTION:The mammary is a highly plastic organ that undergoes epithelial remodeling several times over the course of a mammal’s lifetime. Physiological development of the mammary is well established in literature\, but the role tight junctions play in shaping the mammary gland is less understood. Development of epithelial tissues depends\, in part\, on the adherence of cells to maintain tissue integrity while remodeling. Claudin 7\, a tight junction protein expressed in the developing epithelia\, exhibits a strong presence in mammary epithelia. In this thesis we explore potential roles of claudin 7 in epithelial remodeling. We used a Cre/flox system to design an in vivo mammary-specific Cldn7 knockout. We validated our mouse line genotype using PCR genotyping. We used carmine alum staining\, hematoxylin and eosin staining\, and immunofluorescent staining to visualize wild type and Cldn7 Cre/flox mammary glands. This thesis furthers the knowledge of mammary gland morphogenesis by providing a foundation for a new approach to mammary remodeling in vivo.
UID:147932-21902565@events.umich.edu
URL:https://events.umich.edu/event/147932
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biology,Bsbsigns,Thesis Defense
LOCATION:Biological Sciences Building - 3150
CONTACT:
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