A strategy for stereospecific cross-coupling of chiral Csp3-organometallic complexes will be described. The method relies on the Pd-catalyzed cross-coupling of stereodefined Csp3-Cu-complexes that are catalytically generated in situ from simple alkenes. This reaction, in a single operation, converts readily available alkenes to products that contain two new bonds and two new stereocenters. The mechanism of these processes is addressed with experimental and computational techniques.
Kevin Brown, Indiana University
Metal-Catalyzed Alkene Functionalization: An Approach Towards Stereospecific Cross-Coupling