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Presented By: Center for the Discovery of New Medicines - CDNM

Drug Discovery Lecture Series: "Fishing, Drug Development and the Prevention of Acquired Hearing Loss"

Ed Rubel, Ph.D.

Edwin W Rubel, Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology- Head and Neck Surgery, Department of Physiology and Biophysics, University of Washington, Seattle

Dr. Rubel will present studies aimed at the discovery of genes and drugs that will help us understand how and why inner ear hair cells die as a result of a variety of intrinsic and extrinsic challenges such as therapeutic drugs. The goal is to discover cellular pathways and new reagents to prevent hearing cell loss and balance disorders. Dr. Rubel's lab has been using the lateral line system of larval zebrafish, Daneio rerio, to study modifiers of aminoglycoside and cisplatin hair cell toxicity. This platform is particularly advantageous for in vivo cellular analyses, for genetic screening and for screening large drug libraries to find protective or toxic compounds. Large numbers of animals can be efficiently processed and a variety of fluorescent markers have been identified that can be used to dynamically examine the viability and cellular processes of hair cells in living animals.

Dr. Rubel will focus on two aspects of this work. The first will be a series of studies aimed at understanding the disruption calcium regulation that leads to hair cell death. The second example will be studies attempting to develop a new drug that will prevent hearing loss by screening small molecule libraries of drug-like compounds, medicinal chemistry and preclinical testing, including proof of concept evaluation in mammals.

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