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DTSTAMP:20180125T125519
DTSTART;TZID=America/Detroit:20180208T140000
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SUMMARY:Presentation:Neurobiological and hormonal regulation of decision making
DESCRIPTION:Every day\, we are faced with a multitude of decisions that require choices among options involving potentially costly consequences. While the majority of us are able to make effective and adaptive decisions\, this ability is significantly compromised in several psychiatric diseases\, such as substance use disorders (SUDs). The neural mechanisms underlying such impairments\, however\, are largely unknown. This is a significant gap in our understanding of diseases like SUDs\, as remediating impaired decision making represents a potentially powerful intervention to mitigate continued pathological behavior\, such as continued substance use and relapse. Before we can address this\, however\, we first need to understand the mechanisms underlying normal decision-making processes. To begin to address this\, our research has focused on understanding both neurobiological and hormonal contributions to adaptive decision making. Using a variety of techniques\, we find that the basolateral amygdala is a critical substrate for decision-making behavior and that its contributions depend on the phase of the decision process (deliberating between available choices vs. evaluating the outcomes of those choices). We also find that males and females differ in these types of decision processes and that this difference is largely due to estradiol’s regulatory effect on decision making in females. These findings lay the groundwork for future research\, which will identify the circuits with which the basolateral amygdala communicates during decision making and will determine whether estradiol mediates its effect on choice behavior via regulation of brain systems involved in cost/benefit decision making. Collectively\, this information will ultimately enable identification of candidate targets for improving decision making in individuals suffering from various psychiatric diseases\, with the long-term goal of preventing future pathological behavior and disease recurrence.
UID:48245-11191513@events.umich.edu
URL:https://events.umich.edu/event/48245
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Life Science,Psychology
LOCATION:East Hall - 4448
CONTACT:
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