Presented By: Michigan Lifestage Environmental Exposures and Disease Center
Placental-Maternal-Fetal Communication Vesicles, and Pregnancy Health
Yoel Sadovsky, MD
The trophoblast at the feto-maternal interface fulfills functions that are critical for embryonic development, including gas exchange, supply of nutrients, removal of waste products, endocrine regulation, and immunological defense. In his lab, Dr. Sadovsky utilizes molecular and cellular approaches to decipher mechanisms underlying placental development, differentiation, and response to injury. Using cultured primary human placental cells, genetically-altered mice, and placental samples from human pregnancies, his lab examines molecular mechanisms underlying trophoblast response to diverse stressors that adversely influence the homeostatic balance between cell injury and adaptation. Dr. Sadovsky’s research assesses how these stressors contribute to placental dysfunction and fetal growth restriction (FGR), which predispose to childhood neurodevelopmental dysfunction and adult metabolic syndrome.
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