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DTSTAMP:20190419T181532
DTSTART;TZID=America/Detroit:20190419T110000
DTEND;TZID=America/Detroit:20190419T120000
SUMMARY:Workshop / Seminar:Quantitative Biology Seminar | Lineage tracing in cellular reprogramming reveals selective dynamics
DESCRIPTION:Cellular reprogramming is a phenomenon where mature\, specialized cells can be reprogrammed to immature cells capable of developing into all tissues of the body. Do cells individual cells differ in their ability to reprogram? We address this using cellular barcoding based lineage tracing\, and demonstrate that reprogramming dynamics in large \"interacting\" populations are dominated by “elite” clones [1]. This work highlights the importance of cellular interactions and/or epigenetic heterogeneity in fate programming outcomes. In contrast\, tissue regeneration in animals exhibit neutral dynamics between the underlying population of stem cells [2]. Taken together\, we show that looking at cell fate transition from the lens of eco-evolutionary lens shed light on underlying biology. \n
UID:63147-15578798@events.umich.edu
URL:https://events.umich.edu/event/63147
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Physics,Science
LOCATION:West Hall - 340
CONTACT:
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