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BEGIN:VEVENT
DTSTAMP:20200311T121559
DTSTART;TZID=America/Detroit:20200407T114500
DTEND;TZID=America/Detroit:20200407T130000
SUMMARY:Other:Harnessing the Winstein Rearrangement: Dynamic Chemistry of Allylic Azides
DESCRIPTION:                                                                           Chiral amines are ubiquitous motifs in organic molecules of societal value. The synthesis of certain chiral amines remains a synthetic challenge. Presented herein is an unusual approach to chiral amine synthesis that utilizes the spontaneous rearrangement of allylic azides (Winstein Rearrangement). One component of the equilibrating mixture can be selectively trapped\, establishing the amine bearing stereocenter. However\, accomplishing this in practice requires high levels of selectivity and the simultaneous application of numerous control elements. Approaches to enabling selectivity will be described along with synthetic applications of the reactions\, including in the synthesis of heterocyclic products.                                                                      \n                       \n                                                \n                       \n                                                \n                       \n                                                \n                       \n                                                \n                       \n                        \nJoseph Topczewski (University of Minnesota)
UID:67854-16960495@events.umich.edu
URL:https://events.umich.edu/event/67854
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biosciences,Chemistry,Science
LOCATION:Chemistry Dow Lab - 1300 
CONTACT:
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