Happening @ Michigan https://events.umich.edu/group/3761/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Reactive nitrogen compounds and their contribution to new particle formation and growth (March 28, 2024 4:00pm) https://events.umich.edu/event/117509 117509-21839405@events.umich.edu Event Begins: Thursday, March 28, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Atmospheric new particle formation (NPF) followed by growth of the particles to ~50-100 nm accounts for ~50% of the particles that can activate cloud droplets. As such, constraining how aerosols affect cloud lifecycle, properties, and processes and, more generally, the earth’s radiative balance requires knowledge of NPF and growth processes. However, our understanding of NPF and growth remains incomplete because these processes are governed by a complex interplay between the chemistry and physical state of the atmosphere. Additionally, ambient measurements of molecules, such as amines, that have been proposed to be important for NPF are sparse, thus limiting our ability to evaluate the global importance of different nucleation mechanisms. In this talk, I will discuss our work on NPF and growth at the Department of Energy Atmospheric Radiation Measurement Southern Great Plains (SGP) research station, one of the longest-running atmospheric measurement sites in North America. At this agricultural site, we investigate NPF and growth using a combination of long-term measurements of aerosol size distributions and intensive operating periods in which we measure NPF and growth precursors and chemically characterize the growing clusters using mass spectrometry. Our measurements provide insight into the contribution of various oxidized and reduced reactive nitrogen compounds to these processes and highlight the importance of ambient measurements in providing the scientific information required to improve our understanding of aerosol-cloud interactions.

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Workshop / Seminar Tue, 12 Mar 2024 11:32:13 -0400 2024-03-28T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Gomberg Lecture - How a Love of RNA Biophysics Lead to the Discovery of a Novel Antiviral (April 1, 2024 4:00pm) https://events.umich.edu/event/109301 109301-21821365@events.umich.edu Event Begins: Monday, April 1, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Positive Strand RNA viruses persist to pose serious threats to human health and global economies. Disease progression mediated by viral pathogenesis requires numerous intersections between host proteins and viral RNA (vRNA) structures. Host-vRNA complexes drive essential processes in the replication cycles of viruses; as such, they represent untapped targets for therapeutic intervention. In my seminar, I will describe the mechanisms by which the mutually antagonistic human hnRNP A1 and AUF1 proteins compete for the same vRNA structure to differentially regulate Enterovirus (EV) translation efficiency. By screening a library of small molecule RNA binders, we discovered that the compound DMA-135 binds SLII IRES domain to dose-dependently inhibit viral replication by attenuating viral translation. Serial passaging of EV-A71 in the presence of low doses of DMA-135 selects for revertant viruses with drug-resistant mutations that map to the SLII bulge environment. Comparative structure-function studies reveal that the cellular mechanism of action of DMA-135 is to tip the SLII-hnRNP regulatory axis towards significantly lower levels of IRES-dependent translation, and the virus can compensate by evolving mutations that restore homeostasis. Our work defines the antiviral mechanism of action of DMA-135; it demonstrates that functional specificity can be modulated through natural and drug-dependent viral evolution; and it shows how small molecules can reveal new insights about host-virus interfaces that regulate early stages of EV replication.

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Workshop / Seminar Tue, 19 Mar 2024 11:34:13 -0400 2024-04-01T16:00:00-04:00 2024-04-01T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
AbbVie Symposium "Development of a Scalable Route for the Drug-Linker of Immunology ADC ABBV-154" (April 2, 2024 11:30am) https://events.umich.edu/event/120818 120818-21845351@events.umich.edu Event Begins: Tuesday, April 2, 2024 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A scalable route has been developed to the bromoacetamide glucocorticoid drug-linker used in conjugation with the monoclonal antibody (mAb) adalimumab to produce antibody-drug conjugate ABBV-154. Optimization and insights will be discussed into the key transformations and isolations including a challenging acetal deprotection, amide coupling between an aniline and dipeptide, phosphate formation via a phosphoramidite displacement and oxidation, Fmoc cleavage with a continuous extraction, bromoacetic acid coupling, and a global acidic deprotection. Notably, the final deprotection of three t-butyl protecting groups proceeds through several intermediates and is complicated by acetal epimerization. This complex reaction was initially optimized in a batch setup, but scaling issues prompted the development of a flow process with an impinging jet mixing element.

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Conference / Symposium Wed, 27 Mar 2024 14:48:56 -0400 2024-04-02T11:30:00-04:00 Chemistry Dow Lab Department of Chemistry Conference / Symposium Chemistry Dow Lab
AbbVie Symposium "Electrochemical Methods for Reductive Cross-Coupling Reactions" (April 2, 2024 4:00pm) https://events.umich.edu/event/120820 120820-21845352@events.umich.edu Event Begins: Tuesday, April 2, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The seminar will describe our group's efforts towards the development of scalable, mild, and general electrosynthetic methodologies for cross-coupling reactions. Many of the discussed electrosynthetic methodologies are possible because of a synergy between conventional transition metal catalysts for cross coupling and redox-active mediators developed by the battery community. Electrocatalytic reactions are dramatically improved with the incorporation of co-catalytic quantities of redox mediators that serve to assist in electron transfer, protect catalysts from degradation by over-oxidation/reduction, or promote in the formation of otherwise inaccessible catalytic intermediates. Additionally, a general approach to cross-coupling will be presented that relies on the electrosynthesis of organometallic reagents that undergo radical capture and coupling.

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Conference / Symposium Wed, 27 Mar 2024 14:50:14 -0400 2024-04-02T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Conference / Symposium Chemistry Dow Lab
Harnessing energy flow in molecules & nanomaterials: A tale of forbidden transitions, molecular motions, and exotic excitations (April 4, 2024 4:00pm) https://events.umich.edu/event/109302 109302-21821367@events.umich.edu Event Begins: Thursday, April 4, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Spectroscopy has the potential to reveal the structure and dynamics of complex materials, ranging from chromophores in solution to molecular aggregates and nanomaterial heterostructures. Yet, disentangling spectral signals and extracting an intuitive picture of how excitations form, move, and exchange energy is one of the deepest and most persistent challenges of physical chemistry. In this talk, I will offer two vignettes on our work developing and applying approaches to predict and understand spectral features in molecular and nanomaterial systems. In the molecular world, I will show how our recent advances in condensed phase spectroscopy enable us to decipher a long-standing puzzle in porphyrin photophysics: why and how do the Q bands involved in energy transfer in photosynthesis and artificial energy conversion split? In the nanomaterial world, I will highlight how we have been able to demonstrate how the unusual photophysics of atomically thin 2D materials enables hot carrier extraction for photocatalysis. Then, I will illustrate how addressing the challenge of hot carrier extraction enabled us to develop a simple scheme to disentangle the signals of exotic quasiparticles that explain the tunability of the optical behavior of these materials as a function of potential, laser fluence, and time.

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Workshop / Seminar Tue, 26 Mar 2024 08:47:54 -0400 2024-04-04T16:00:00-04:00 2024-04-04T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Physical Chemistry 3rd Year Seminars (April 5, 2024 4:00pm) https://events.umich.edu/event/117620 117620-21839702@events.umich.edu Event Begins: Friday, April 5, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstracts TBD

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Workshop / Seminar Mon, 22 Jan 2024 10:48:00 -0500 2024-04-05T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Gomberg Lecture - Guy Bertrand (April 8, 2024 4:00pm) https://events.umich.edu/event/109303 109303-21821368@events.umich.edu Event Begins: Monday, April 8, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Wed, 26 Jul 2023 08:21:46 -0400 2024-04-08T16:00:00-04:00 2024-04-08T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Jenny Yang Seminar (April 9, 2024 4:00pm) https://events.umich.edu/event/109304 109304-21821369@events.umich.edu Event Begins: Tuesday, April 9, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Tue, 25 Jul 2023 16:44:50 -0400 2024-04-09T16:00:00-04:00 2024-04-09T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Vanessa Huxter Seminar (April 11, 2024 4:00pm) https://events.umich.edu/event/113887 113887-21831865@events.umich.edu Event Begins: Thursday, April 11, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Thu, 21 Mar 2024 15:53:49 -0400 2024-04-11T16:00:00-04:00 2024-04-11T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Nina Hartrampf Seminar (April 12, 2024 4:00pm) https://events.umich.edu/event/120687 120687-21845136@events.umich.edu Event Begins: Friday, April 12, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Mon, 25 Mar 2024 11:37:58 -0400 2024-04-12T16:00:00-04:00 2024-04-12T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Gomberg Lecture - Amy Rosenzweig (April 15, 2024 4:00pm) https://events.umich.edu/event/108132 108132-21818977@events.umich.edu Event Begins: Monday, April 15, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Amy Rosenzweig (Northwestern University)

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Lecture / Discussion Wed, 26 Jul 2023 08:22:46 -0400 2024-04-15T16:00:00-04:00 2024-04-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Lecture / Discussion Chemistry Dow Lab
Jeff Martell Seminar (April 16, 2024 4:00pm) https://events.umich.edu/event/109305 109305-21821370@events.umich.edu Event Begins: Tuesday, April 16, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Tue, 25 Jul 2023 16:21:31 -0400 2024-04-16T16:00:00-04:00 2024-04-16T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Gomberg Lecture - Dinshaw Patel (April 22, 2024 4:00pm) https://events.umich.edu/event/108086 108086-21818925@events.umich.edu Event Begins: Monday, April 22, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Lecture / Discussion Wed, 26 Jul 2023 08:35:09 -0400 2024-04-22T16:00:00-04:00 2024-04-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Lecture / Discussion Chemistry Dow Lab
Kate Waldie Seminar (April 23, 2024 4:00pm) https://events.umich.edu/event/118446 118446-21841083@events.umich.edu Event Begins: Tuesday, April 23, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Tue, 06 Feb 2024 09:11:33 -0500 2024-04-23T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Alexander Miller Seminar (April 24, 2024 4:00pm) https://events.umich.edu/event/109306 109306-21821371@events.umich.edu Event Begins: Wednesday, April 24, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Wed, 26 Jul 2023 08:20:48 -0400 2024-04-24T16:00:00-04:00 2024-04-24T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Renee Frontiera Seminar (April 25, 2024 4:00pm) https://events.umich.edu/event/109307 109307-21821372@events.umich.edu Event Begins: Thursday, April 25, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Tue, 25 Jul 2023 16:27:02 -0400 2024-04-25T16:00:00-04:00 2024-04-25T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Gomberg Lecture - Adrian Ferre-D'Amare (April 29, 2024 11:00am) https://events.umich.edu/event/109308 109308-21821373@events.umich.edu Event Begins: Monday, April 29, 2024 11:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Wed, 26 Jul 2023 08:40:40 -0400 2024-04-29T11:00:00-04:00 2024-04-29T12:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Keary Engle Seminar (May 2, 2024 4:00pm) https://events.umich.edu/event/117276 117276-21839094@events.umich.edu Event Begins: Thursday, May 2, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Wed, 17 Jan 2024 10:54:21 -0500 2024-05-02T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Amanda Morris Seminar (May 7, 2024 4:00pm) https://events.umich.edu/event/109861 109861-21823109@events.umich.edu Event Begins: Tuesday, May 7, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Mon, 07 Aug 2023 08:11:46 -0400 2024-05-07T16:00:00-04:00 2024-05-07T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Amanda Cook Seminar (May 21, 2024 4:00pm) https://events.umich.edu/event/110271 110271-21824706@events.umich.edu Event Begins: Tuesday, May 21, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD.

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Workshop / Seminar Wed, 16 Aug 2023 09:11:42 -0400 2024-05-21T16:00:00-04:00 2024-05-21T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Biophysics Symposium 2024 (May 31, 2024 9:00am) https://events.umich.edu/event/120414 120414-21844744@events.umich.edu Event Begins: Friday, May 31, 2024 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Chemistry

Faculty Talks:
Shyamal Mosalaganti (LSI)
Dawen Cai (CDB)
Somin Eunice Lee (EECS)

More info TBD

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Conference / Symposium Wed, 20 Mar 2024 11:11:21 -0400 2024-05-31T09:00:00-04:00 2024-05-31T16:00:00-04:00 Rackham Graduate School (Horace H.) Department of Chemistry Conference / Symposium Rackham Graduate School (Horace H.)
Elizabeth Parkinson, Purdue (September 10, 2024 4:00pm) https://events.umich.edu/event/108298 108298-21819257@events.umich.edu Event Begins: Tuesday, September 10, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio

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Other Wed, 19 Jul 2023 06:15:19 -0400 2024-09-10T16:00:00-04:00 2024-09-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Elizabeth Parkinson Seminar | Host: Wang (September 10, 2024 4:00pm) https://events.umich.edu/event/109309 109309-21821374@events.umich.edu Event Begins: Tuesday, September 10, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Cluster: ChemBio
Institution: Purdue University
Title:
Abstract:

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Workshop / Seminar Tue, 18 Jul 2023 09:23:33 -0400 2024-09-10T16:00:00-04:00 2024-09-10T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
commUNITY Seminar (October 16, 2024 4:00pm) https://events.umich.edu/event/116964 116964-21838255@events.umich.edu Event Begins: Wednesday, October 16, 2024 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Title & Abstract TBD

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Workshop / Seminar Wed, 10 Jan 2024 16:54:43 -0500 2024-10-16T16:00:00-04:00 2024-10-16T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab