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Please let us know as soon as possible in order to have adequate time (one week preferred) to arrange for your requested accommodation(s) or an effective alternative.", "occurrence_notes":null, "guid":"80356-20707775@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/80356", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Online", "has_livestream":0, "cost":"", "tags":["Graduate Students"], "website":"https:\/\/rackham.umich.edu\/event\/graduate-student-career-pathways-job-and-internship-search-strategies\/", "sponsors":[ { "group_name":"Rackham Graduate School", "group_id":"1187", "website":"https:\/\/www.facebook.com\/umichgradschool" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":20707775 } , "80413-20719667": { "datetime_modified":"20210106T082334", "datetime_start":"20210115T130000", "datetime_end":"20210115T140000", "has_end_time":1, "date_start":"2021-01-15", "date_end":"2021-01-15", "time_start":"13:00:00", "time_end":"14:00:00", "time_zone":"America\/Detroit", "event_title":"PhD Defense: Charles Park", "occurrence_title":"", "combined_title":"PhD Defense: Charles Park: Immunoengineering Approaches for the Treatment of Cancer and Prevention of Infectious Diseases", "event_subtitle":"Immunoengineering Approaches for the Treatment of Cancer and Prevention of Infectious Diseases", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"NOTICE: This event will be held remotely via Zoom. The link will be placed below.\r\n\r\nZoom: https:\/\/umich-health.zoom.us\/j\/97318374664?pwd=YTB4dzNTVXdRZDZQcGR1dVRLZi9JUT09\r\n\r\nWith the recent progress in technologies, analyzing detailed cellular interactions that constitute the immune system have become possible, and many more biological and engineering tools became within reach for precise investigation and modulation of immune responses. As a result, immunotherapies, such as anti-PD-1 antibody and chimeric antigen receptor T cells, have revolutionized cancer immunotherapy, while genome sequencing and nanotechnology allowed for the rapid development of various vaccines in response to the recent outbreak of Coronavirus Disease 2019. Here, first discussed is modulation of the immune responses using biomaterials, such as silica- or lipid-based nanoparticles and immunomodulating agents for cancer immunotherapy. My approach for immune modulation was to deliver vaccine or pattern recognition receptor-stimulating drugs using nanoparticles to enhance the activation of antigen presenting cells at the innate immune response stage, which leads to stronger adaptive immune responses. In addition, induction of a stronger chemokine gradient to recruit more T cells to tumor from the blood circulation was investigated. In the next study, use of lipid-based nanoparticle to formulate vaccines against infectious diseases, such as human immunodeficiency virus-1 (HIV-1) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is introduced. Nanoparticle-mediated vaccine delivery increases the amount of antigen reaching lymph nodes to interact with immune cells. Also, co-delivery of adjuvants further induces stronger adaptive immune responses. Meanwhile, it is critical to preserve the epitope conformation when protein antigens are used for vaccine formulation, in order to induce functional neutralizing antibodies. The aim of the study was to co-load a subunit protein and an adjuvant into lipid-based nanoparticles while maintaining the structural intactness and induce enhanced antibody responses when vaccinated to animals. Overall, immune modulation strategies are introduced in therapeutic or prophylactic settings, where innate and adaptive immune responses were enhanced using biomaterials-based treatments.\r\n\r\nChair: Dr. James J. Moon", "occurrence_notes":null, "guid":"80413-20719667@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/80413", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Off Campus Location", "has_livestream":0, "cost":"", "tags":["Basic Science","Biointerfaces","Biology","biomedical","biomedical engineering","Bioninterfaces","Biosciences","Biotechnology","bme","engineering","Life Science","Science"], "website":"https:\/\/umich-health.zoom.us\/j\/97318374664?pwd=YTB4dzNTVXdRZDZQcGR1dVRLZi9JUT09", "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", "website":"https:\/\/www.facebook.com\/profile.php?id=100094127215673" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2021\/01\/event_80413_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2021\/01\/event_80413_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2021\/01\/event_80413_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2021\/01\/event_80413_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2021\/01\/event_80413_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2021\/01\/event_80413_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2021\/01\/event_80413_original-1.png" }, "occurrence_count":1, "first_occurrence":20719667 } , "79706-20456302": { "datetime_modified":"20210130T123034", "datetime_start":"20210115T141500", "datetime_end":"20210115T153000", "has_end_time":1, "date_start":"2021-01-15", "date_end":"2021-01-15", "time_start":"14:15:00", "time_end":"15:30:00", "time_zone":"America\/Detroit", "event_title":"MTR Virtual Spring Preview Day 2020", "occurrence_title":"", "combined_title":"MTR Virtual Spring Preview Day 2020", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"For Prospective Applicants:\n - 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These walk-in sessions will be a chance to ask any final questions about the application, hiccups in the system, recommendations, submission. There will be a \"waiting room\" for the Zoom call and applicants will be let in based on the order they arrive. Conversations will be limited to 10 minutes to allow everyone a chance to participate.\r\n\r\nMonday - Wednesday - Friday: 3:00pm-4:00pm\r\nZoom Link: https:\/\/umich.zoom.us\/j\/92939407296\r\n\r\nTuesday - Thursday: 11:00am-12:00pm\r\nZoom Link: https:\/\/umich.zoom.us\/j\/97863212974\r\n\r\nIf there is anything we can do to make this event accessible to you, please contact us. Please be aware that advance notice is necessary as some accommodations may require more time for the university to arrange.", "occurrence_notes":null, "guid":"67233-16828986@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/67233", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Off Campus Location", "has_livestream":1, "livestream_type":"other", "livetream_require_login":0, "livestream_id":"", "livestream_link":"", "cost":"", "tags":["International"], "website":"http:\/\/ii.umich.edu\/flas", "sponsors":[ { "group_name":"International Institute", "group_id":"1968", "website":"http:\/\/www.ii.umich.edu" }, { "group_name":"Center for Japanese Studies", "group_id":"1003", "website":"" }, { "group_name":"Center for Southeast Asian Studies", "group_id":"1044", "website":"http:\/\/www.ii.umich.edu\/cseas" }, { "group_name":"Center for Middle Eastern and North African Studies", "group_id":"2563", 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It challenges people of all ages to learn about the unique perspective of elders whose lived struggles created opportunities for future generations and to confront the experiential divides that can grow larger due to generational differences. \r\n\r\nIn the play, Calvin Jones (Wendell Pierce), a hip, coolly intellectual African-American college professor moves his 82-year-old ailing, but doggedly independent, father, Donald Jones (Charlie Robinson), from Greenwald, MS into his Harlem penthouse. The play begins with an argument over what to eat for breakfast, then turns into a generational clash over race, opportunity, and a decision that Calvin made years ago. Donald\u2019s grumpiness is peppered with disturbing outbursts, revealing bits of his past, informed by growing up Black and poor in the South. \r\n\r\nThemes of social justice themes and intergenerational conflict make Some Old Black Man a fitting title for our times, when the reality of more togetherness unveils some of the tensions underlying even the closest of relationships. \r\n\r\nThe play was filmed in Detroit after the creative team quarantined together during rehearsals in Ann Arbor under strict safety protocols.\r\n\r\nAfter the digital premiere, join the creative team for a live talkback. 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