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        "event_title":"Juneteenth Symposium: Celebrating Black Joy, Hope, and Healing\u2014Opening",
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        "description":"The Research Team within LSA Technology Services is excited to announce virtual office hours for research computing support. These are regularly scheduled times when we will have subject matter experts in geographic information systems, high performance computing, digital scholarship, and computer programming available for drop-in support. Faculty, staff, and students with research-related questions pertaining to any of these areas can stop by to ask questions, get help working through a problem, or inquire about a new project\u2014no appointment necessary!\r\n\r\nNot sure what we can do to help? Read on for more details about the services provided by each of these teams.\r\n\r\n*Digital Scholarship*\r\nOur digital scholarship team specializes in humanities, social sciences, and interdisciplinary digital project methods and can provide assistance with:\r\n* Conceptualizing, planning, and finding resources for a digital project\r\n* How to version, archive, and preserve a project\r\n* Sustainability, preservation, accessibility, privacy, consent, or grant requirements\r\nNew to digital projects? We can also talk about how to demonstrate the scholarly rigor of your digital project, accurately credit the labor required of the project at every stage, and how to provide evidence and metrics for promotion and job dossiers.\r\n\r\n*Geographic Information Systems (GIS)*\r\n\r\nOur GIS specialists can help with your geographic data needs, including the following:\r\n* Making maps for use in a class, grant proposal, or publication\r\n* Geospatial analysis: identifying spatial patterns and trends in your data\r\n* Georeferencing: assigning geographic coordinates to a historic paper map or a hand-drawn sketch for digital use as a basemap or combined display with other data\r\n* Geocoding: convert a spreadsheet with addresses into latitude-longitude so you can plot your data on a map\r\n* StoryMaps: harness the power of maps to tell your story\r\n* Integrating smartphones or tablets and GIS in your field courses or researchSetting up workshops for a class or group interested in learning to use GIS in the context of your discipline\r\n* Assistance with ESRI's ArcGIS platform, including ArcGIS Pro and ArcGIS Online, or other geospatial software\r\n* Developing your own custom GIS web application or mobile application\r\n\r\n*High Performance Computing (HPC)*\r\n\r\nOur HPC team can help with:\r\n* Accessing U-M\u2019s new Great Lakes HPC (High Performance Computing) cluster\r\n* Moving your computational work from your laptop or workstation to the cluster, freeing up your machines for other tasks\r\n* Compiling, installing, or configuring a wide range of computational software\r\n* Setting up automated workflows to save time\r\n* Debugging your programs to see why they are crashing\r\n* Evaluating the benefits of parallel computing, more memory or system resources for your code\r\nWe regularly support Python, R, MATLAB, C\/C++, Java, Julia, Go, and many other applications.\r\n\r\n*Research Support Programming*\r\n\r\nOur computer programming team can help with any of the following:\r\n\r\n* Debugging, repair, and improvements or upgrades to your existing code\r\n* References to training and coding resources to assist in your project\r\n* Design and development of custom software to support your research\r\n* Incorporation of lab-specific hardware into custom software applications.\r\n* Writing funding for any of the above into your grant proposals\r\nWe're experienced in MATLAB, Python, R, LabVIEW, JavaScript, MedPC, iOS development, and more.\r\n\r\nWho can join the office hours?\r\nLSA Faculty, staff, and students with research-related questions on geographic information systems, high performance computing, digital scholarship, and computer programming\r\n\r\nWhen and where is it?\r\nOur virtual office hours use Zoom:\r\nMondays, 2:00\u20133:00 P.M.\r\nTuesdays, 10:00\u201311:00 A.M.\r\nThursdays, 3:00\u20134:00 P.M.",
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        "description":"Registration Required: https:\/\/umich.zoom.us\/webinar\/register\/WN_uLz-ONHVQPuRINMYUNvBJQ\r\n\r\n\u201cCCR5 as a model to examine reporter assays in evaluating translational phenomena\u201d\r\nYousuf Khan\r\nKnight-Hennessy Scholar\r\nStanford University\r\n\r\nKEYWORDS: dual luciferase, frameshifting, recoding, CCR5\r\nABSTRACT: During the decoding of a subset of mRNAs, a proportion of ribosomes productively shift to the \u22121 reading frame at specific slippage-prone sites in a phenomenon known as programmed \u22121 ribosomal frameshifting (\u22121 PRF) to generate a frameshifted, C-terminally unique protein. The first experimentally verified occurrence of functionally utilized non-retroelement derived \u22121 PRF in humans has been reported in the mRNA encoding the immune-functioning C-C chemokine receptor 5 (CCR5). Here, we show that frameshifting does not occur during CCR5 decoding. Apart from its importance in understanding expression of a gene relevant to cancer, an HIV-1 receptor (and the associated claimed rationale for generating the first humans derived from genetically modified embryos), the findings imply that caution is appropriate in assessing results from translational reporter assays.\r\n\r\n~and~\r\n\r\n\u201cIntersection between RNA methylation and TDP43-mediated toxicity in ALS\u201d\r\nMichael McMillan\r\nPh.D. candidate\r\nCellular and Molecular Biology\r\nUniversity of Michigan\r\n\r\nKEYWORDS: TDP43, m6A, ALS, RNA stability\r\nABSTRACT: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting in the death of upper and lower motor neurons. ALS has no known cure and limited therapeutic options, and the underlying pathological mechanisms remain unclear. Despite considerable variability in clinical presentation, over 95% of ALS cases exhibit cytoplasmic inclusions of the RNA binding protein TDP43. Emerging evidence suggests that TDP43 is crucial for RNA stability, and that dysregulation of RNA homeostasis may contribute to ALS pathogenesis.\r\nMethylation of RNA at the 6th position nitrogen (N6-methyladenosine methylation, or m6A) by methyltransferases (writers) or removal of methyl groups by demethylases (erasers) has dramatic effects on RNA stability and translation mediated by a family of RNA biding proteins that recognize methylated RNA (readers). m6A writers and erasers specifically localize to nuclear speckles, membraneless nuclear organelles rich in RNA binding proteins and splicing factors, including TDP43. Together with our data showing that TDP43 regulates RNA stability, these observations suggest that TDP43 may destabilize m6A modified RNA. Here, we show that methylated RNA co-purified with TDP43 from cultured cells via RNA immunoprecipitation, and abrogation of methylation sites disrupted TDP43 binding, suggesting that TDP43 recognizes m6A modified RNA in cellulo. We also noted profound and widespread hypermethylation of coding and non-coding transcripts in ALS spinal cord, many overlapping with confirmed TDP43 target transcripts. Consistent with a central role for m6A modification in TDP43-mediated toxicity, we identified several factors operating within the m6A pathway that enhance or suppress the toxicity of TDP43 in rodent primary cortical neurons via a single-cell CRISPR\/Cas9 candidate-based screen. Genetic knockout of the established m6A reader YTHDF2 rescued TDP43 toxicity in primary neurons, and YTHDF2 was also upregulated in ALS postmortem sections. Together, these data imply a fundamental link between m6A RNA modifications and ALS pathogenesis, potentially mediated by TDP43-dependent RNA destabilization.",
        "occurrence_notes":"Registration Required: https:\/\/umich.zoom.us\/webinar\/register\/WN_uLz-ONHVQPuRINMYUNvBJQ",
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        "tags":["Basic Science","Biointerfaces","Biology","Biomedical Engineering","Biosciences","Chemistry","Drug Discovery","Graduate","Graduate School","Lecture","Life Science","Medicine","Natural Sciences","Pharmacy","Postdoctoral Research Fellows","Pre Med","Public Health","Rackham","Research","Science","Structural Biology"],
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                "group_name":"Center for RNA Biomedicine",
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