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        "event_title":"Homework Help at The Children's Center",
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        "combined_title":"Homework Help at The Children's Center",
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        "description":"The Homework Help program offers children assistance with their homework assignments. Children are encouraged to bring homework and are paired with a volunteer to assist them. This program is a critical service in helping children thrive. Volunteers give children the tools they need to be successful in school.Virtual and in-person volunteer opportunities are available. If you would like to volunteer, please start the enrollment process by creating an account on the Children Center's\u00a0Volunteer Site found HERE.\u00a0After your account is created, the Children's Center will reach out to you within 2 business days to answer any questions and discuss the next steps.In accordance with the CMS Vaccine Mandate, those volunteering in-person at the Children\u2019s Center are required to be fully vaccinated and must provide proof of full vaccination upon request.",
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        "event_title":"UROP 2022-2023 Rising Sophomore Applications Open",
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        "description":"The Undergraduate Research Opportunity Program is now accepting applications for students who will be rising sophomores during the 2022-2023 academic year.\r\n\r\nLearn more and apply today at http:\/\/myumi.ch\/uropsophomore\r\n\r\nRising Sophomore Applications are being accepted on a rolling basis.",
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        "event_title":"Apply to Changing Gears",
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        "combined_title":"Apply to Changing Gears: Research experience for Transfer Students",
        "event_subtitle":"Research experience for Transfer Students",
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        "description":"Changing Gears (CG) is a UROP program designed primarily for community college transfer students who will be attending the University of Michigan, but also serves students transferring from 4 year institutions. Students in the CG Program become a part of an ongoing faculty-driven research, scholarly or creative project in their field of interest. Students learn valuable academic skills, applying these skills to their research project, academics, and future career opportunities, while receiving academic credit or compensation for their efforts in research work.\r\n\r\nApplications are accepted on a rolling basis.\r\nLearn more about Changing Gears at: myumi.ch\/uropcg",
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        "event_title":"Lane Hall Gallery Summer Exhibit",
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        "combined_title":"Lane Hall Gallery Summer Exhibit: \"Invisible Women: Portraits of Aging in Ukraine\" Photographs by Ashley Bigham and Watercolors by Grace Mahoney",
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        "description":"In this exhibit, artists Ashley Bigham (photographs) and Grace Mahoney (watercolors) investigate the visibility and social role of Ukraine\u2019s older generation of women embodied in a figure both iconic and ubiquitous: the babusya. Seen in public transport, in the market, and on the street, each babusya has a story to tell. Each has something to say, something to gossip about, and something to complain about. \r\n\r\n\"Invisible Women: Portraits of Aging in Ukraine\" is hosted by the University of Michigan\u2019s Institute for Research on Women and Gender (IRWG) and the Department of Women\u2019s and Gender Studies. The exhibit is on display for public viewing weekdays from 8:00 a.m.- 4:00 p.m. through August 18, 2022, in the main lobby of Lane Hall, located at 204 South State Street, Ann Arbor, MI 48109. For more information on the current exhibit, visit IRWG\u2019s website.",
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        "time_start":"08:00:00",
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        "event_title":"Map \u2260 Territory: Distortion and Power in Cartography",
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        "combined_title":"Map \u2260 Territory: Distortion and Power in Cartography",
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        "description":"More than strict representations of the world we inhabit, maps are social constructions that embody the interests of their creators. Map \u2260 Territory deconstructs maps that have been used to subjugate, appropriate, and oppress, as well as the maps that counter that power through emancipation and advocacy. The exhibit critically engages with materials that span from the colonial era to modern-day Detroit.\r\n\r\nThe exhibit is available in the Clark Library (second floor Hatcher) during Hatcher Library hours. Please verify hours on the library's website: https:\/\/www.lib.umich.edu",
        "occurrence_notes":null,
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        "has_livestream":0,
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        "tags":["Library","Maps"],
        "website":"",
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        "event_title":"UROP First-Year Application Open",
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        "combined_title":"UROP First-Year Application Open",
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        "time_end":"23:00:00",
        "time_zone":"America\/Detroit",
        "event_title":"UROP Research Scholars Program Application Open",
        "occurrence_title":"",
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        "event_subtitle":"Continue your UROP research experience",
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        "occurrence_notes":"Apply at: myumi.ch\/uroprs",
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        "event_title":"Design and Implementation of Web Surveys - Summer Institute in Survey Research Techniques",
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        "combined_title":"Design and Implementation of Web Surveys - Summer Institute in Survey Research Techniques: Course presented by Frederick Conrad,\u00a0Florian Keusch & Christopher Antoun",
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        "occurrence_title":"",
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        "description":"Analysis of Complex Sample Survey Data\r\n\r\nOpen for registration!\r\n\r\nJune 6 - July 29, 2022\r\n10:00am-12:00pm\r\nM\/W\/F\r\n\r\nThis course provides practical methods and tools to analyze complex survey data with a hands-on introduction to the use of specialized statistical software procedures. The course focuses on case studies with specific large-scale national surveys: the National Comorbidity Survey-Replication (NCS-R), the National Health and Nutrition Examination Surveys (NHANES), and the Health and Retirement Study (HRS). Relevant design features of the NCS-R, NHANES and HRS include survey weights that take into account differences in probability of selection into the sample and differences in response rates, as well as stratification and clustering in the multistage sampling procedures used in identifying the sampled households and individuals. After introducing essential concepts related to complex sample designs, the course will turn to the construction of survey weights, estimation of sampling variance, descriptive analysis, regression analysis, and finally special topics in the analysis of survey data. Participants can expect to work on homework exercises, computer lab exercises, and a final analysis project.\r\n\r\nWhy take this course? \r\n- To gain an understanding of modern methods and software for the secondary analysis of survey data collected from large complex samples\r\n- To have the opportunity for one-on-one interaction with the instructors when walking through analyses of survey data\r\n- To see various examples of applied statistical analyses of survey data\r\n- To have the experience of writing a scientific paper that presents an analysis of complex sample survey data, and getting expert feedback on that paper.\r\n\r\nCourse Hours: 3\r\n\r\nInstructors: Brady T. West, Yajuan Si\r\n\r\nPrerequisite: Two graduate-level courses in statistical methods, familiarity with basic sample design concepts, and familiarity with data analytic techniques such as linear and logistic regression.\r\n\r\nAll 2022 courses will be offered in an alternative remote format.",
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        "tags":["Anthropology","Basic Science","Data","Data Curation","Data Management","Data Science","Economics","Education","Graduate","Information and Technology","Integrative Systems","Interdisciplinary","Mathematics","Multidisciplinary Design","Political Economy","Political Science","Population Studies Center","Psychology","Public Policy","Research","Science","Social Sciences","Sociology","Survey Research","Training"],
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        "description":"Agonist antibodies that activate co-stimulatory immune receptors, such as the tumor necrosis factor (TNF) receptors OX40 and CD137, are an important class of emerging therapeutics due to their ability to regulate immune cell activity. Despite their promise, there are no approved agonist antibodies for treating cancer as demonstrated by previous unsuccessful clinical trials. Although multiple factors are responsible for poor clinical efficacy, one major bottleneck is the reliance on Fc\u03b3R-mediated crosslinking for sufficient receptor activation. This is inherently problematic because Fc\u03b3R expression varies greatly on different immune cells, leading to a wide range of receptor agonism. Emerging research suggests that antibodies engaging two different epitopes on the same immune receptor mediate receptor superclustering and enable robust antibody agonism without extrinsic Fc crosslinking. However, there are no systematic methods for identifying such biepitopic (also known as biparatopic) agonist antibodies. Therefore, the objective of this research work is to develop facile methods for reliably identifying biepitopic antibodies to activate immune receptors for immunotherapeutic applications.\r\n\r\nBiepitopic antibodies have been shown to mediate potent receptor activation for a variety of immune receptors. Traditionally, the generation of these antibodies requires key steps including animal immunization, epitope binning to identify unique antibody pairs, and combining antibody pairs to engineer biepitopic antibodies. While this approach has been used to successfully discover biepitopic antibodies, it suffers from key limitations. Notably, animal immunization and subsequent antibody isolation is an arduous and unpredictable process. Even when successful clones are discovered from these processes, further epitope binning experiments are needed to select antibody pairs to discover potent immune therapeutics. To overcome these limitations, we developed an antibody screening strategy that greatly simplifies the discovery of biepitopic antibodies. Our approach eliminates the need for animal immunization by using existing, off-the-shelf IgG antibodies specific to the target receptor. Next, we perform in vitro selections by blocking the receptor epitope of the existing antibody and conducting subsequent sorts to identify single-chain antibodies with orthogonal binding domains. Thus far, our work has shown that the antibody screening strategy can be used to discover antibodies for a variety of TNF receptors including OX40 and CD137.\r\n\r\nGiven that receptor clustering of three or more receptors is critical for activating TNF receptors, we first generated biepitopic tetravalent OX40 antibodies by attaching novel single-chain antibodies to the C-termini of the light chain of existing clinical-stage antibodies. These tetravalent biepitopic antibodies showed remarkable T cell proliferation and cytokine secretion for biepitopic antibodies compared to their monoepitopic counterparts. Next, we sought to improve the additional clinical-stage OX40 IgGs engineered as biepitopic antibodies to show the generality of our findings that biepitopic antibodies can mediate superior and Fc\u03b3R-independent activities. Beyond OX40 IgGs, we also show that biepitopic antibodies can be used to mediate superior T cell proliferation for other TNF receptors including CD137. Looking forward, we anticipate that these research advancements will accelerate the discovery and development of the next generation of immune therapeutics.\r\n\r\nDate: Friday, July 29, 2022\r\nTime: 10:00 AM\r\nZoom: https:\/\/umich.zoom.us\/j\/5163583658\r\nCo-Chairs: Professors Peter Tessier and Lonnie Shea",
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        "time_zone":"America\/Detroit",
        "event_title":"ScribeAmerica Virtual Information Session July 29th",
        "occurrence_title":"",
        "combined_title":"ScribeAmerica Virtual Information Session July 29th",
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        "event_title":"Summer Institute in Survey Research Techniques",
        "occurrence_title":"",
        "combined_title":"Summer Institute in Survey Research Techniques: Courses and Workshops, June 6-July 29, 2022",
        "event_subtitle":"Courses and Workshops, June 6-July 29, 2022",
        "event_type":"Class \/ Instruction",
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        "description":"Open for registration!\r\n\r\nThe Summer Institute offers courses on (1) research design and sample selection, (2) measurement, (3) qualitative methods in survey research design, (4) data collection, and (5) analysis.\r\n\r\nMulti-week courses provide more in-depth coverage of a topic, include readings, homework, and examinations, and often providing participants with an opportunity to practice survey techniques.  One-week courses give an overview of a methodology topic, including readings and homework.  One-day workshops are offered for those who need to learn a specific technique or method in a short period of time.\r\n\r\nAll 2022 courses will be offered in an alternative remote format.",
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        "tags":["Basic Science","Career","Corporate","Economics","Graduate","Graduate Students","Information and Technology","International","Kinesiology","Mathematics","Professional Development","Psychology","Public Policy","Research","Science","Sociology","Training"],
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        "event_title":"Heartfulness Guided Meditation",
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