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        "date_start":"2026-09-14",
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        "time_start":"11:00:00",
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        "event_title":"Human Genetics Research Seminar Series",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Yang Shi, PhD Professor of Epigenetics Ludwig Institute for Cancer Research, Oxford University, Oxford, England",
        "event_subtitle":"presenting Yang Shi, PhD Professor of Epigenetics Ludwig Institute for Cancer Research, Oxford University, Oxford, England",
        "event_type":"Lecture \/ Discussion",
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        "description":"Monday, September 14, 2026\r\n11:00am - 12:00pm\r\nLocation TBD\r\n\r\nYang Shi, PhD\r\nProfessor of Epigenetics\r\nLudwig Institute for Cancer Research\r\nOxford University, Oxford, England\r\n\u201cSeminar Title TBD\u201d\r\n\r\nHosted By: Shigeki Iwase, PhD, Department of Human Genetics\r\n___\r\nBefore joining Ludwig Oxford in 2020, I was Professor of Cell Biology and C. H. Waddington Professor of Pediatrics at Harvard Medical School. I received my PhD from New York University and postdoctoral training at Princeton University. I joined Harvard Medical School as an Assistant Professor in 1991 and was appointed a Professor of Pathology in 2004. In 2009 I joined the Newborn Medicine Division of Boston Children\u2019s Hospital.\r\n\r\nI am interested in identifying key epigenetic regulators in cancer, elucidating their mechanism of action and providing the conceptual basis for translating our basic findings to the clinic via the development of new therapeutic strategies. With the discovery of the first histone methyl eraser, LSD1, in 2004, our group demonstrated that histone methylation is dynamically regulated, which overturned the long-held dogma that such modifications were static and irreversible. We have also discovered many additional histone demethylases with different specificities, and novel readers, including those that specifically recognize unmodified lysine and arginine and suggest that the unmodified states are not simply a ground neutral state of epigenetic information but rather likely code for epigenetic information as modified states. Importantly, many of these chromatin enzymes and readers have since been implicated in various types of human cancers, indicating an important role of chromatin regulation in tumorigenesis.\r\n\r\nMore recently, we have also been studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology, i.e., the nature and the biological and pathological functions of RNA modifications, as well as the enzymes responsible for writing, erasing and reading them, are just beginning to be understood.\r\n\r\nAt Ludwig Oxford, my lab is focusing on two questions. First, how to convert \u201ccold tumors to \u201chot\u201d and how to sustain durable responses to cancer immune checkpoint blockade therapy. Second, how to induce therapeutic differentiation of cancers, using acute myeloid leukemia and diffuse intrinsic pontine glioma as models where chromatin\/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state.",
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        "tags":["Postdoctoral Research Fellows","Human Genetics, Genetics, Neurogenetic Diseases","Information and Technology","lecture","Life Science","lifton","Medicine","Natural Sciences","neel","neurological disease","Human Genetics, Genetics, Epidemiology","Public Health","Public Policy","Reception","research","Science","seminar","sodium channel","symposium","Chemistry","basic sciences","biolgical chemistry","biological chemistry","biological science","Biology","Biosciences","Bsbsigns","cancer","Basic Science","Discussion","epilepsy","Faculty","Free","genetics","genome","genomics","human genetics"],
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