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DTSTART:20070311T020000
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DTSTAMP:20230912T104729
DTSTART;TZID=America/Detroit:20230920T160000
DTEND;TZID=America/Detroit:20230920T171500
SUMMARY:Workshop / Seminar:Wenjing Wang Promotion Seminar
DESCRIPTION:Talk Title: Protein-based tools for studying brain signaling and neurodegenerative diseases\n\nAbstract: One major challenge in neuroscience is capturing and manipulating neuronal signaling and modulation with high spatiotemporal resolution and across a large brain volume. To address this gap\, my research group takes a chemical biology approach to design novel classes of protein-based sensors and tools. For example\, we have designed new classes of fluorescence-integrators which generate permanent marks upon detection of specific neuromodulators. These fluorescence-integrators will enable whole-brain mapping of opioids\, epinephrine\, dopamine\, and other neuromodulators with high spatial resolution. We have also designed light- and chemical-activated protein switches for controlling the activity of peptide agonists for G protein-coupled receptors (GPCRs)\, which will enable the activation of GPCRs in selective neuronal circuits to study their causal-effect on various physiological processes and behaviors. These protein-based sensors and tools will significantly facilitate the study of brain signaling and neuromodulation. Another significant hurdle in neuroscience is the lack of reagents to target misfolded a-synuclein (a-syn) protein aggregates\, a hallmark of synucleinopathies. We have designed a-syn fibril-selective nanobodies which show efficacy in inhibiting pathology development in cultured neurons and mouse models. The a-syn fibril-selective nanobodies will provide valuable tools for studying synucleinopathies.
UID:109252-21821312@events.umich.edu
URL:https://events.umich.edu/event/109252
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Chemical Biology,Chemistry,Science
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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