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DTSTAMP:20260106T105426
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SUMMARY:Workshop / Seminar:DCMB Tools and Technology Seminar by Jonah Rosenblum
DESCRIPTION:Abstract\nGenomic data from a single institution lacks global diversity representation\, especially for rare variants and diseases. Confidential computing can enable collaborative genome-wide association studies (GWAS) without compromising privacy or accuracy. However\, due to limited secure memory space and performance overheads\, previous solutions fail to support widely used regression methods. Here we present SECRET-GWAS—a rapid\, privacy-preserving\, population-scale\, collaborative GWAS tool. We discuss several system optimizations\, including streaming\, batching\, data parallelization and reducing trusted hardware overheads to efficiently scale linear and logistic regression to over a thousand processor cores on an Intel SGX-based cloud platform. In addition\, we protect SECRET-GWAS against several hardware side-channel attacks. SECRET-GWAS is an open-source tool and works with the widely used Hail genomic analysis framework. Our experiments on Azure’s Confidential Computing platform demonstrate that SECRET-GWAS enables multivariate linear and logistic regression GWAS queries on population-scale datasets from ten independent sources in just 4.5 and 29 minutes\, respectively.\n\nAbout the DCMB Tools & Technology Seminar Series\n\nThe DCMB Tools and Technology Seminar Series is held in Medical Science Building 1 (MS1)\, Room 4B700\, each Thursday at 12pm EST. Each seminar highlights a computational tool\, technology\, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.\n\nThese seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel
UID:143264-21892599@events.umich.edu
URL:https://events.umich.edu/event/143264
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,Bioinformatics,Biology,Biosciences,Life Science,Research,Virtual
LOCATION:Medical Science Unit I - Room 4B700
CONTACT:
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