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DTSTART:20070311T020000
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DTSTAMP:20260409T105118
DTSTART;TZID=America/Detroit:20260420T130000
DTEND;TZID=America/Detroit:20260420T140000
SUMMARY:Workshop / Seminar:Single Cell Spatial Analysis Monthly Seminar Series
DESCRIPTION:TITLE: Simultaneous CRISPR screening and spatial transcriptomics reveals intracellular and intercellular transcriptional circuits.\n\nFEATURING: \nSamouil L. Farhi\, Ph.D.  Director of the Spatial Technology Platform at the Broad Institute of MIT and Harvard\n\nFor more details Visit: https://singlecellspatialanalysis.umich.edu/monthlyseminarseries/\nZoom Info: \nMeeting ID: 998 7259 4985\nPasscode: 786053\n\nABSTRACT: \nPerturb-FISH combines spatial transcriptomics with optical detection of in situ amplified guide RNAs. Perturb-FISH recovers intracellular effects that are consistent with Perturb-seq results in cultured monocytes\, and finds density-dependent regulation of the innate immune response. Pairing Perturb-FISH with a functional readout in a screen of autism spectrum disorder risk genes\, shows common calcium activity phenotypes in induced pluripotent stem cell derived astrocytes and their associated molecular pathways. Finally\, Perturb-FISH can identify neighborhood dependent perturbation effects in a complex tissue by showing immune-tumor interactions in a xenograft model engrafted with human PBMCs. Perturb-FISH is thus a general method for studying the genetic and molecular associations of spatial and functional biology at single-cell resolution.
UID:147561-21901279@events.umich.edu
URL:https://events.umich.edu/event/147561
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Agent Based Modelling,Ai In Science And Engineering,Artificial Intelligence,autophagy,Basic Science,Bioinformatics,Biointerfaces,Biology,biomedical,Biomedical Engineering,biomedical research,biomedicine,biophysics,Biosciences,cancer,cells,Complex Systems Modelling,Computational Science,Drug Discovery,Engineering,epigenetics,Faculty,Faculty Candidate,Free,genetics,Graduate,Graduate and Professional Students,Graduate School,Graduate Students,human genetics,Human Genetics\, Genetics\, Epidemiology,Life Science,Medicine,Natural Sciences,Neuroscience,Postdoctoral Research Fellows,Science,seminar,Structural Biology,Virtual
LOCATION:North Campus Research Complex Building 10 - Research Auditorium
CONTACT:
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