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DTSTART:20070311T020000
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DTSTAMP:20261023T105331
DTSTART;TZID=America/Detroit:20261113T120000
DTEND;TZID=America/Detroit:20261113T130000
SUMMARY:Workshop / Seminar:MCDB Seminar Series> Identification of enhancer regulatory variants that shape root system architecture
DESCRIPTION:Variation in regulatory DNA is thought to be a major factor driving phenotypic variation in wild species as well as domestication of cultivated plants. Enhancers\, a type of regulatory DNA sequence\, regulate target gene expression in a spatiotemporal manner and can be relatively distal to their target genes\, thus making them difficult to characterize. We performed a genome-wide association study and identified genetic variants associated with aspects of root system architecture in a collection of domesticated and wild tomato accessions. Using a massively parallel reporter assay\, we tested and confirmed their relative allelic activity in vivo. A gene\, PERI\, associated with one of these variants is precisely spatiotemporally expressed in lateral root precursor cells. PERI expression varies according to its allele variant in cultivars within the association mapping panel and is required for lateral root development. Collectively\, these data demonstrate the importance of enhancers in shaping root system architecture in tomato and its wild relatives.\n\nBio: Siobhan specializes in the regulation of gene expression in plant roots. Her research integrates\ngenomics\, molecular biology\, and bioinformatics to understand how transcriptional\nnetworks control root development and response to environmental stress. By dissecting\nthese complex regulatory pathways\, she aims to uncover the mechanisms that enable\nplants to adapt to changing conditions\, contributing to advancements in agricultural\nbiotechnology and crop improvement. Her work is pivotal in developing resilient plant\nvarieties for sustainable agriculture.
UID:151240-21911138@events.umich.edu
URL:https://events.umich.edu/event/151240
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biology,Bsbsigns
LOCATION:Biological Sciences Building - 1060
CONTACT:
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