Presented By: Department of Psychology
CCN FORUM: Growth Charting Brain Networks: Progress, Pitfalls, and Plans for the Future
Chandra Sripada, Assocaite Professor, University of Michigan, Departments of Psychiatry and Philosophy
Pediatricians use growth charts to map the typical development of key somatic variables—such as height and head circumference—which in turn enables reliable early detection of youth following abnormal developmental trajectories. For the last 18 months, our group has attempted to extend this basic idea to the brain. Our goal has been to construct growth charts for large-scale brain functional networks that are involved in key neurocognitive functions, such sustained attention, working memory, and flexible reasoning. In this talk, I review our progress. Some (tentative) findings to be discussed include: Maturation of the connectome is not a unitary phenomenon – rather, there appear to be roughly 6 to 12 independently maturing “components” of the connectome. In addition, we find evidence for the “impulsivity as immaturity” hypothesis. Specifically, we find that immaturity of components of the functional connectome (quantified through growth charting) is a robust predictor of reduced scores on multiple measures of executive functioning. Finally, novel approaches for modeling connectomic development, such as supervised source separation methods and mixture regression methods, will be discussed.
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