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DTSTART:20070311T020000
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DTSTAMP:20210301T100833
DTSTART;TZID=America/Detroit:20210302T113000
DTEND;TZID=America/Detroit:20210302T130000
SUMMARY:Workshop / Seminar:CSCS Seminar: New data\, models\, and methods to guide SARS-CoV-2 vaccine design and vaccination programs that counter escape mutations
DESCRIPTION:Join Link: myumi.ch/v2ZYv\n\nABSTRACT: \nBefore the emergence of escape mutants that now threaten pandemic control\, we constructed and analyzed the first model integrating immune waning and escape mutations. In the model\, escape mutants were not problematic until a year into the pandemic. After they emerged\, vaccination could worsen the pandemic. We examined four patterns by which existing escape mutants could stimulate further escape mutations. These provide insights in how to pursue epitope (the part of an antigen recognized by the immune system) specific model analyses. The time is ripe for this advance. The pandemic has unveiled new high-throughput methods to characterize immunity at an epitope specific and B and T cell specific levels. We will present our model and discuss how it could integrate systems immunology and systems epidemiology.
UID:82119-21036721@events.umich.edu
URL:https://events.umich.edu/event/82119
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biology,Biosciences,Natural Sciences,Public Health,Research
LOCATION:Off Campus Location
CONTACT:
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