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DTSTAMP:20220120T181529
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SUMMARY:Other:Structure-Function Relationships of Single Fluorescent Macromolecules  
DESCRIPTION:When chemical reactivity is measured for a series of systematically related molecules\, a structure-function relationship can be derived that summarizes the effect of the perturbation. This seminar will develop the idea of studying chemistry with single molecule structure-function relationships. In our implementation\, optical tweezers are used to isolate a tethered single molecule and apply a force bias to create sub-ensembles of well-defined extension. For fluorescent molecules\, the intrinsic optical emission can provide a probe of function. Ongoing research will be discussed\, including an investigation into the green fluorescent family of proteins. These proteins share a common chromophore capable of a diverse range of photochemistries (electron transfer\, proton transfer\, isomerization\, oxidative addition) whose reactivity is determined by subtle environmental changes.          \n                                                \n                       \n                                                \nZiad Ganim (Yale University)
UID:88613-21656201@events.umich.edu
URL:https://events.umich.edu/event/88613
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biosciences,Chemistry,Science
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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