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Presented By: Office of Research School of Dentistry

Deciphering mechanisms of organismal phosphate regulation

Lauren Surface, PhD

Lauren Surface, PhD Lauren Surface, PhD
Lauren Surface, PhD
EDUCATION
Massachusetts Institute of Technology, Cambridge, MA, USA
Doctor of Philosophy in Biology, September 2007-June 2014
University of Washington, Seattle, WA, USA
Honors Bachelor of Science in Neurobiology, September 2002-June 2006
POSITIONS AND ACADEMIC APPOINTMENTS
2021-Present Assistant Professor, University of Michigan School of Dentistry
2022-Present Faculty Member, Cellular and Molecular Biology Graduate Program, University of Michigan
2019-2021 Instructor in Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA
2017-2019 Research Fellow, Endocrine Unit, Lab of Dr. Michael Mannstadt, MGH, Boston, MA
2015-2017 Postdoctoral Associate, Department of Molecular and Cellular Biology, Lab of Dr. Erin O’Shea,

Harvard University, Cambridge, MA

2007-2014 Graduate Research Fellow, Department of Biology, Lab of Dr. Laurie Boyer, MIT, Cambridge, MA
2006 Research Assistant, Department of Orthobiology, Lab of Dr. Mary Murphy,

National University of Ireland, Galway, Ireland

2005-2006 Undergraduate Research Fellow, Department of Genome Sciences, Lab of Dr. Leo Pallanck,

University of Washington, Seattle, WA

2003-2005 Undergraduate Research Fellow, Department of Biochemistry, Lab of Dr. Brian Kennedy,

University of Washington, Seattle, WA
ACADEMIC AND PROFESSIONAL HONORS
2021 University of Michigan Biological Sciences Scholar, Ann Arbor, MI
2019 Most Outstanding Poster, Bisphosphonates 50th Anniversary Meeting
2018 Endocrine Fellows Foundation Forum Travel Grant, Fellows Forum on Metabolic Bone Disease
2018 AIMM-ASBMR John Haddad Young Investigator Fellow
2017 American Society for Bone and Mineral Research Young Investigator Travel Grant Award,
2019 MIT Vertex Scholar, Cambridge, MA
2007 MIT Presidential Scholar
2006 University of Washington Herschel and Caryl Roman Undergraduate Science Scholar
2006 University of Washington Mary Gates Research Scholar
GRANTS AND FELLOWSHIPS
Current
NIH/NIAMS K99/R00 Pathway to Independence Award,
K99 period: August 2019-Sept 2021, R00 period: Feb 2022-Jan 2025
Title: Deciphering mechanisms of nitrogen-containing bisphosphonates, R00 funding: $249,000/year for 3 years

Previous
2018-2019 NIH T32 Training Grant Trainee, 2018-2019, Endocrinology Division, Massachusetts General Hospital
2017 American Cancer Society Postdoctoral Fellowship, 2017
PUBLICATIONS
Bondeson, D.P., Paolella, B.R., Asfaw, A., Rothberg, M., Skipper, T., Mesa, G., Gonzalez, A., Surface, L.E., Ito, K.,
Kazachkova, M., Colgan, W.N., Warren, A., Dempster, J., Krill-Burger, J., Ericsson, M., Tang, A., Fung, I., Chambers,
E.S., Abdusamad, M., Dumont, N., Doench, J.G., Piccioni, F., Root, D.R., Boehm, J., Hahn, W.C, Mannstadt, M.,
McFarland, J.M., Vazquez, F., Golub, T.R., (2022) Phosphate dysregulation via the XPR1:KIDINS220 protein
complex is a therapeutic vulnerability in ovarian cancer., Nature Cancer, 6:681-695

Surface,L.E., Burrow, D.T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., Lee, B.H.,
Mumm, S., Gu, C., Baker, J.C., Mohseni, M., Sum, M., Huskey, M., Duan, S., Bijanki, V.N., Civitelli, R., Gardner,
M.J., McAndrew, C.M., Ricci, W.M., Gurnett, C.A., Diemer, K., Wan, F., Costantino, C.L., Shannon, K.M., Raje, N.,
Dodson, T.B., Haber, D.A., Carette, J.E., Varadarajan, M., Brummelkamp, T.R., Birsoy, K., Sabatini, D.M., Haller, G.,
Peterson, T.R., (2020) ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Science
Translational Medicine, 12:544, eaav9166
Yu, Z., Surface, L.E., Park, C.Y., Horlbeck, M.A., Wyant, G.A., Abu-Remaileh, M., Peterson, T.R., Sabatini, D.M.,
Weissman, J.S., O’Shea, E.K., (2018) Identification of a transporter complex responsible for the cytosolic entry of
nitrogen-containing bisphosphonates. Elife 7:e36620
Surface, L.E., Fields, P.F, Subramanian, V., Behmer, R., Udeshi, N., Peach, S.E., Carr, S.A., Jaffe, J.D., Boyer, L.A.
(2016) H2A.Z.1 monoubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs. Cell Reports, 14, 1142-
1155. *equal contribution
Subramanian, V., Mazumder, A., Surface, L.E., Butty, V.L., Fields, P.A., Alwan, A., Torrey, L., Thai, K.K., Levine,
S.S., Bathe, M., Boyer, L.A. (2013) H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression
programs during ESC differentiation. PLoS Genetics, 9, e1003725
Klattenhoff, C., Sheuermann, J.C., Surface, L.E., Bradley, R.K., Fields, P., Steinhauser, M.L., Ding, H., Butty, V.L.,

Torrey, L., Haas S., Abo, R., Tabebordbar, M., Lee, R.T., Burge, C.B., Boyer, L.A. (2013) Braveheart, a long non-
coding RNA required for cardiovascular lineage commitment. Cell 152, 1-14. *equal contribution

Surface, L.E., Thornton, S.R., Boyer, L.A. (2010) Polycomb group proteins set the stage for early lineage
commitment. Cell Stem Cell 7, 288-298. *equal contribution
Lockshon, D., Surface L.E., Kerr, E.O., Kaeberlein, M., Kennedy, B.K. (2007). The sensitivity of yeast mutants to
oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175, 77-91.
SERVICE & OUTREACH EXPERIENCE
Member, American Society of Bone and Mineral Research, Early Stage Investigator Committee, 2022-Present
Member, Oral Health Sciences PhD Program Committee University of Michigan, 2022-Present
Abstract Reviewer, American Society of Bone and Mineral Research, Annual Meeting, 2020-Present
Workshop Committee Member, Center for Skeletal Research, 2019-2021
-Plan instructional workshops for the Boston-area skeletal research community.
Grant Reviewer, Seeding Labs (Non-profit science development organization), Boston, MA, 2016-Present
-Review grant applications for instrument access grants provided to laboratories in developing countries
-Contributed to data analysis of existing grants
Mentor, Science Club for Girls, Roxbury, MA, 2015-2019
-Led middle school girls from diverse backgrounds in weekly science clubs on Saturdays to engage them with
science and technology
Postdoc Liason Committee, Harvard Department of Molecular and Cellular Biology, 2015-2017
-Served on a committee that advocates for issues relevant for postdocs and beyond. Advocated for the
department to consider a preprint server policy, and bringing in a more diverse set of scientists for talks.
Science Fair Judge, Quincy High School, Quincy, MA, 2010-2021
-Judged the science fair of a diverse high school near Boston, and spoke with attendees about my own career
path through science.
Lauren Surface, PhD Lauren Surface, PhD
Lauren Surface, PhD

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