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BEGIN:VEVENT
DTSTAMP:20260107T120418
DTSTART;TZID=America/Detroit:20260413T110000
DTEND;TZID=America/Detroit:20260413T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, April 13\, 2026\n11:00am - 12:00pm\n1020 Kahn Auditorium\, BSRB\n\nJacy Wagnon\, PhD\nAssistant Professor\nDepartment of Neuroscience\nThe Ohio State University College of Medicine\n“Seminar Title TBD”\n\nHosted By: Miriam Meisler\, PhD\, Department of Human Genetics\n___\nDevelopmental and epileptic encephalopathies (DEE) are a genetically heterogeneous group of neurological disorders characterized by early-onset seizures along with cognitive\, motor\, and behavioral impairments. The Wagnon laboratory is interested in understanding genetic and molecular mechanisms underlying DEE and identifying new treatment strategies for these severe disorders. Our current studies focus on DEE caused by variants in the neuronal voltage-gated sodium channel gene SCN8A. We are developing mouse models of SCN8A encephalopathy to study pathogenesis of seizures and related comorbidities. A second focus of the lab is to investigate the role of regulation of gene expression in seizure pathology. Changes in mRNA and microRNA levels represent a general transcriptional response to seizures that may implicate new therapeutic targets.
UID:143371-21892958@events.umich.edu
URL:https://events.umich.edu/event/143371
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:Taubman Biomedical Science Research Building - 1020 Kahn Auditorium
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260107T120429
DTSTART;TZID=America/Detroit:20260420T110000
DTEND;TZID=America/Detroit:20260420T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, April 20\, 2026\n11:00am - 12:00pm\n1020 Kahn Auditorium\, BSRB\n\nAaron Ragsdale\, PhD\nAssistant Professor\nIntegrative Biology\nUniversity of Wisconsin-Madison\n“Seminar Title TBD”\n\nHosted By: Jeffrey Kidd\, PhD\, Department of Human Genetics\n___\nOur research aims to understand how evolutionary forces are expected to shape genetic diversity within populations\, and then uses this understanding to learn about demographic and selective histories and processes from genome sequencing data. One focus of our research is on developing population genetic theory that lets us predict patterns of diversity and genetic structure under varying models of demography and selection. Another focus is on turning that theory into computational tools to compare model predictions to observations from natural populations. Finally\, we have a strong interest in inferring (mostly) human evolutionary history from genetic data\, including both ancient history and population structure as well as more recent migrations\, movements\, and dynamics.
UID:143372-21892957@events.umich.edu
URL:https://events.umich.edu/event/143372
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Epidemiology,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:Taubman Biomedical Science Research Building - 1020 Kahn Auditorium
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260107T120451
DTSTART;TZID=America/Detroit:20260504T110000
DTEND;TZID=America/Detroit:20260504T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, May 4\, 2026\n11:00am - 12:00pm\n1020 Kahn Auditorium\, BSRB\n\nAlex Pollen\, PhD\nAssistant Professor\nNeurobiology\nDevelopmental & Stem Cell Biology\nUniversity of California\, San Francisco\n“Seminar Title TBD”\n\nHosted By: Xander Nuttle\, PhD\, Department of Human Genetics\n___\nWe study how genetic changes that accumulated over the last 6 million years of human evolution influence specialized features of brain development using single cell genomics\, cerebral organoid models of ape brain development\, and genome engineering.\n\nOver the last six million years\, human cognition has changed in remarkable ways to support symbolic language\, long-term planning\, cooperation on vast scales\, and the rapid cultural accumulation of technology. During this time\, patterns of brain development and life history changed to triple the number of neurons produced prenatally\, extend synaptic plasticity through a prolonged phase of development\, and restructure connectivity between brain regions. At the same time tens of millions of mutations accumulated as fixed changes in the human genome through the processes of selection and drift. A portion of this new genomic information guides the development of uniquely human traits and contributes to disease vulnerabilities shared by all humans. However\, connecting human-specific mutations to recently evolved traits remains a major challenge because we lack experimental systems for comparative and functional studies of great ape cortical development. To identify genomic differences underlying unique features or vulnerabilities of the human brain\, we are incorporating advances in single cell genomics and genome engineering with great ape cerebral organoid models of brain development. We are enthusiastic for new graduate students to join the team\, and the lab is well suited for those with an interest in evolution\, neuropsychiatric disorders\, neuronal cell diversity\, stem cell models\, or bioinformatics.
UID:143397-21893075@events.umich.edu
URL:https://events.umich.edu/event/143397
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Epidemiology,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:Taubman Biomedical Science Research Building - 1020 Kahn Auditorium
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20260107T120504
DTSTART;TZID=America/Detroit:20260511T110000
DTEND;TZID=America/Detroit:20260511T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, May 11\, 2026\n11:00am - 12:00pm\n1020 Kahn Auditorium\, BSRB\n\nTony Capra\, PhD\nProfessor\nBakar Computational Health Sciences Institute\nDepartment of Epidemiology and Biostatistics\nUniversity of California\, San Francisco\n“Seminar Title TBD”\n\nHosted By: Xinjun Zhang\, PhD\, Department of Human Genetics\n___\nWe use the tools of computer science and statistics to address problems in genetics\, evolution\, and biomedicine. For a summary of our major research foci\, see Research.\n\nOur group is located in the Bakar Computational Health Sciences Institute and the Department of Epidemiology and Biostatistics at the University of California\, San Francisco. Prior to coming to UCSF\, Tony spent 7 wonderful years at Vanderbilt University.\n\nHumans differ from one another and our closest living relatives\, the chimpanzees\, in a wide range of traits\, including our susceptibility to many diseases. We model the evolutionary processes that have produced these novel traits and develop algorithms that compare genomes to predict the functional relevance of specific genetic differences between individuals and species.
UID:143393-21893074@events.umich.edu
URL:https://events.umich.edu/event/143393
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Epidemiology,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:Taubman Biomedical Science Research Building - 1020 Kahn Auditorium
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20260107T120515
DTSTART;TZID=America/Detroit:20260518T110000
DTEND;TZID=America/Detroit:20260518T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, May 18\, 2026\n11:00am - 12:00pm\n1020 Kahn Auditorium\, BSRB\n\nArneet Saltzman\, PhD\nAssistant Professor\nDepartment of Cell & Systems Biology\nUniversity of Toronto\n“Seminar Title TBD”\n\nHosted By: Stephanie Bielas\, PhD\, Department of Human Genetics\n___\nMost of the cells in an organism share the same genome sequence\, yet they are able to carry out many distinct functions. Along with other layers of gene regulation\, chromatin modification plays a key role in this cellular specialization. Our research focuses on histone modifications such as lysine methylation\, and the proteins that recognize these modifications\, which are often referred to as chromatin ‘readers’. Chromatin readers can recruit and act as part of diverse chromatin modifying protein complexes to mediate the silencing of many genes with important functions in cell proliferation and differentiation. We will use a combination of genetic\, biochemical and genome-wide sequencing approaches to investigate the striking regulatory complexity of chromatin readers. Our research will contribute to a better understanding of how cells acquire and maintain different fates during development\, how chromatin readers contribute to epigenetic inheritance\, and how aberrant regulation of histone methylation contributes to the pathogenesis of several human diseases\, including cancers.
UID:143394-21893073@events.umich.edu
URL:https://events.umich.edu/event/143394
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:Taubman Biomedical Science Research Building - 1020 Kahn Auditorium
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260107T102207
DTSTART;TZID=America/Detroit:20260522T120000
DTEND;TZID=America/Detroit:20260522T150000
SUMMARY:Conference / Symposium:James V. Neel\, MD\, PhD Lecture in Human Genetics & Award
DESCRIPTION:Join us as Eric S. Lander\, PhD\, Professor of Biology & Professor of Systems Biology at Harvard Medical School and Founding Director Emeritus at the Broad Institute of MIT\, presents their research at The Department of Human Genetics 25th Annual James V. Neel Lecture.  We will have presentations from our student awardees\, a poster session\, and a light reception. \n\n12:00-2:00 Award Presentations & Keynote Seminar | 1020 Kahn Auditorium\, BSRB\n2:00-3:00 Reception & Poster Session | ABC Seminar Rooms\, BSRB\n\nReady to share your research? Present your poster at the 25th Annual Neel Lectureship. Submit your poster information no later than Friday\, May 8\, 2026 @midnight.\n\n12:00 – Lectureship Begins\n12:15 – Graduate Student Neel Award Presentation (PhD)\n12:30 – Graduate Student Neel Award Presentation (MS/GC)\n1:00 – Keynote Address\n2:00 – Reception Begins/ Poster Session Begins\n3:00 – Conclude
UID:143365-21892954@events.umich.edu
URL:https://events.umich.edu/event/143365
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Epidemiology,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:Taubman Biomedical Science Research Building - 1020 Kahn Auditorium, BSRB & ABC Seminar Rooms
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260107T120530
DTSTART;TZID=America/Detroit:20260914T110000
DTEND;TZID=America/Detroit:20260914T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, September 14\, 2026\n11:00am - 12:00pm\nLocation TBD\n\nYang Shi\, PhD\nProfessor of Epigenetics\nLudwig Institute for Cancer Research\nOxford University\, Oxford\, England\n“Seminar Title TBD”\n\nHosted By: Shigeki Iwase\, PhD\, Department of Human Genetics\n___\nBefore joining Ludwig Oxford in 2020\, I was Professor of Cell Biology and C. H. Waddington Professor of Pediatrics at Harvard Medical School. I received my PhD from New York University and postdoctoral training at Princeton University. I joined Harvard Medical School as an Assistant Professor in 1991 and was appointed a Professor of Pathology in 2004. In 2009 I joined the Newborn Medicine Division of Boston Children’s Hospital.\n\nI am interested in identifying key epigenetic regulators in cancer\, elucidating their mechanism of action and providing the conceptual basis for translating our basic findings to the clinic via the development of new therapeutic strategies. With the discovery of the first histone methyl eraser\, LSD1\, in 2004\, our group demonstrated that histone methylation is dynamically regulated\, which overturned the long-held dogma that such modifications were static and irreversible. We have also discovered many additional histone demethylases with different specificities\, and novel readers\, including those that specifically recognize unmodified lysine and arginine and suggest that the unmodified states are not simply a ground neutral state of epigenetic information but rather likely code for epigenetic information as modified states. Importantly\, many of these chromatin enzymes and readers have since been implicated in various types of human cancers\, indicating an important role of chromatin regulation in tumorigenesis.\n\nMore recently\, we have also been studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology\, i.e.\, the nature and the biological and pathological functions of RNA modifications\, as well as the enzymes responsible for writing\, erasing and reading them\, are just beginning to be understood.\n\nAt Ludwig Oxford\, my lab is focusing on two questions. First\, how to convert “cold tumors to “hot” and how to sustain durable responses to cancer immune checkpoint blockade therapy. Second\, how to induce therapeutic differentiation of cancers\, using acute myeloid leukemia and diffuse intrinsic pontine glioma as models where chromatin/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state.
UID:143395-21893072@events.umich.edu
URL:https://events.umich.edu/event/143395
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Epidemiology,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260107T120540
DTSTART;TZID=America/Detroit:20260921T110000
DTEND;TZID=America/Detroit:20260921T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, September 21\, 2026\n11:00am - 12:00pm\nLocation TBD\n\nIra Hall\, PhD\nProfessor of Genetics\nDirector of the Yale Center for Genomic Health\nYale School of Medicine\n“Seminar Title TBD”\n\nHosted By: Ryan Mills\, PhD\, Department of Human Genetics\n___\nDr. Hall's research career spans the fields of genetics\, genomics\, bioinformatics and data science. He received a B.A. in Integrative Biology from the University of California at Berkeley (1998)\, and worked as a technician for 2 years in Sarah Hake's plant genetics group at the USDA/ARS Plant Gene Expression Center. He received his Ph.D. in genetics from Cold Spring Harbor Laboratory (2003)\, where his work in Shiv Grewal's laboratory established the first direct link between RNA interference and chromatin-based epigenetic inheritance. As a postdoc with Michael Wigler (2004) and independent Cold Spring Harbor Laboratory Fellow (2004-2007)\, Dr. Hall used microarray technologies and mouse strain genealogies to conduct the first systematic study of DNA copy number variation hotspots. As a faculty member at the University of Virginia (2007-2014)\, Washington University (2014-2020) and Yale (2020-present)\, his work has sought to understand the causes and consequences of genome variation in mammals\, with an increasing focus on computational methods development and human genetics. His group has developed bioinformatics tools for variant detection\, variant interpretation\, sequence alignment\, data processing\, and data integration. He has led genome-wide studies of human genome variation\, heritable gene expression variation\, human genetic disorders\, tumor evolution\, mouse strain variation\, genome stability in reprogrammed stem cells\, and single-neuron somatic mosaicism in the human brain. Dr. Hall's work has been featured in Science Magazine's Breakthrough of the Year (2003 & 2007)\, the NIMH Director's \"Ten Best of 2013\" and The Scientist (2013)\, and he has received several prestigious awards including the AAAS Newcomb Cleveland Prize (2003)\, the Burroughs Wellcome Fund Career Award (2006)\, the NIH Director's New Innovator Award (2009)\, and the March of Dimes Basil O'Connor Research Award (2010). He has also served as an Associate Editor at Genome Research (2009-2014) and Genes\, Genomes and Genetics (2011-2018).\n\nMost recently\, Dr. Hall has played a leadership role in several large collaborative projects funded by NIH/NHGRI including the Centers for Common Disease Genomics\, the AnVIL cloud-based data repository and analysis platform\, and the Human Pangenome Project. His current work is focused on two broad goals: (1) mapping variants and genes that confer risk to human disease\, with ongoing projects focused on coronary artery disease and cardiometabolic traits in unique and underrepresented populations\, and (2) developing methods for the detection and interpretation of human genome variation\, with an emphasis on structural variation and other difficult-to-detect forms\, and on comprehensive trait association in human disease studies.
UID:143396-21893071@events.umich.edu
URL:https://events.umich.edu/event/143396
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Epidemiology,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20260107T120553
DTSTART;TZID=America/Detroit:20261012T110000
DTEND;TZID=America/Detroit:20261012T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, October 12\, 2026\n11:00am - 12:00pm\nLocation TBD\n\nMalia Fullerton\, DPhil\nAdjunct Professor\, Epidemiology\nProfessor\, Bioethics and Humanities\nAdjunct Professor\, Genome Sciences\nAdjunct Professor\, Medicine - Medical Genetics\nActing/Interim Center/Institute Director\, School of Public Health\nUniversity of Washington\n“Seminar Title TBD”\n\nHosted By: Wendy R. Uhlmann\, Department of Human Genetics\n___\nStephanie Malia Fullerton\, DPhil\, is Professor of Bioethics and Humanities at the University of Washington School of Medicine. She is also Adjunct Professor in the UW Departments of Epidemiology\, Genome Sciences\, and Medicine (Medical Genetics)\, as well as an affiliate investigator with the Public Health Sciences division of the Fred Hutchinson Cancer Research Center. She received a PhD in Human Population Genetics from the University of Oxford and later re-trained in Ethical\, Legal\, and Social Implications (ELSI) research with a fellowship from the NIH National Human Genome Research Institute.\n\nDr. Fullerton’s work focuses on the ethical and social implications of genomic research and its equitable and safe translation for clinical and public health benefit. She serves as the ELSI lead for the Clinical Sequencing Evidence-Generating Research (CSER2) Consortium coordinating center\, co-chairs the TOPMed Consortium ELSI Committee\, and chairs the Bioethics Advisory Board of the Kaiser Permanente national Research Bank. She contributes to a range of empirical projects focused on clinical genomics translation and precision medicine approaches to the treatment and prevention of cancer and kidney disease in diverse patient populations.
UID:143398-21893070@events.umich.edu
URL:https://events.umich.edu/event/143398
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,basic sciences,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,human genetics,Human Genetics\, Genetics\, Epidemiology,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,Postdoctoral Research Fellows,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium
LOCATION:
CONTACT:
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