{ "143395-21893072": { "datetime_modified":"20260107T120530", "datetime_start":"20260914T110000", "datetime_end":"20260914T120000", "has_end_time":1, "date_start":"2026-09-14", "date_end":"2026-09-14", "time_start":"11:00:00", "time_end":"12:00:00", "time_zone":"America\/Detroit", "event_title":"Human Genetics Research Seminar Series", "occurrence_title":"", "combined_title":"Human Genetics Research Seminar Series: presenting Yang Shi, PhD Professor of Epigenetics Ludwig Institute for Cancer Research, Oxford University, Oxford, England", "event_subtitle":"presenting Yang Shi, PhD Professor of Epigenetics Ludwig Institute for Cancer Research, Oxford University, Oxford, England", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Monday, September 14, 2026\r\n11:00am - 12:00pm\r\nLocation TBD\r\n\r\nYang Shi, PhD\r\nProfessor of Epigenetics\r\nLudwig Institute for Cancer Research\r\nOxford University, Oxford, England\r\n\u201cSeminar Title TBD\u201d\r\n\r\nHosted By: Shigeki Iwase, PhD, Department of Human Genetics\r\n___\r\nBefore joining Ludwig Oxford in 2020, I was Professor of Cell Biology and C. H. Waddington Professor of Pediatrics at Harvard Medical School. I received my PhD from New York University and postdoctoral training at Princeton University. I joined Harvard Medical School as an Assistant Professor in 1991 and was appointed a Professor of Pathology in 2004. In 2009 I joined the Newborn Medicine Division of Boston Children\u2019s Hospital.\r\n\r\nI am interested in identifying key epigenetic regulators in cancer, elucidating their mechanism of action and providing the conceptual basis for translating our basic findings to the clinic via the development of new therapeutic strategies. With the discovery of the first histone methyl eraser, LSD1, in 2004, our group demonstrated that histone methylation is dynamically regulated, which overturned the long-held dogma that such modifications were static and irreversible. We have also discovered many additional histone demethylases with different specificities, and novel readers, including those that specifically recognize unmodified lysine and arginine and suggest that the unmodified states are not simply a ground neutral state of epigenetic information but rather likely code for epigenetic information as modified states. Importantly, many of these chromatin enzymes and readers have since been implicated in various types of human cancers, indicating an important role of chromatin regulation in tumorigenesis.\r\n\r\nMore recently, we have also been studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology, i.e., the nature and the biological and pathological functions of RNA modifications, as well as the enzymes responsible for writing, erasing and reading them, are just beginning to be understood.\r\n\r\nAt Ludwig Oxford, my lab is focusing on two questions. First, how to convert \u201ccold tumors to \u201chot\u201d and how to sustain durable responses to cancer immune checkpoint blockade therapy. Second, how to induce therapeutic differentiation of cancers, using acute myeloid leukemia and diffuse intrinsic pontine glioma as models where chromatin\/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state.", "occurrence_notes":null, "guid":"143395-21893072@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143395", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":null, "has_livestream":0, "cost":"", "tags":["Basic Science","basic sciences","biolgical chemistry","biological chemistry","biological science","Biology","Biosciences","Bsbsigns","cancer","Chemistry","Discussion","epilepsy","Faculty","Free","genetics","genome","genomics","human genetics","Human Genetics, Genetics, Epidemiology","Human Genetics, Genetics, Neurogenetic Diseases","Information and Technology","lecture","Life Science","lifton","Medicine","Natural Sciences","neel","neurological disease","Postdoctoral Research Fellows","Public Health","Public Policy","Reception","research","Science","seminar","sodium channel","symposium"], "website":"https:\/\/medschool.umich.edu\/events?f%5B0%5D=series%3A13266", "sponsors":[ { "group_name":"Department of Human Genetics", "group_id":"1137", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21893072 } , "143396-21893071": { "datetime_modified":"20260107T120540", "datetime_start":"20260921T110000", "datetime_end":"20260921T120000", "has_end_time":1, "date_start":"2026-09-21", "date_end":"2026-09-21", "time_start":"11:00:00", "time_end":"12:00:00", "time_zone":"America\/Detroit", "event_title":"Human Genetics Research Seminar Series", "occurrence_title":"", "combined_title":"Human Genetics Research Seminar Series: presenting Ira Hall, PhD, Professor of Genetics Director of the Yale Center for Genomic Health Yale School of Medicine", "event_subtitle":"presenting Ira Hall, PhD, Professor of Genetics Director of the Yale Center for Genomic Health Yale School of Medicine", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Monday, September 21, 2026\r\n11:00am - 12:00pm\r\nLocation TBD\r\n\r\nIra Hall, PhD\r\nProfessor of Genetics\r\nDirector of the Yale Center for Genomic Health\r\nYale School of Medicine\r\n\u201cSeminar Title TBD\u201d\r\n\r\nHosted By: Ryan Mills, PhD, Department of Human Genetics\r\n___\r\nDr. Hall's research career spans the fields of genetics, genomics, bioinformatics and data science. He received a B.A. in Integrative Biology from the University of California at Berkeley (1998), and worked as a technician for 2 years in Sarah Hake's plant genetics group at the USDA\/ARS Plant Gene Expression Center. He received his Ph.D. in genetics from Cold Spring Harbor Laboratory (2003), where his work in Shiv Grewal's laboratory established the first direct link between RNA interference and chromatin-based epigenetic inheritance. As a postdoc with Michael Wigler (2004) and independent Cold Spring Harbor Laboratory Fellow (2004-2007), Dr. Hall used microarray technologies and mouse strain genealogies to conduct the first systematic study of DNA copy number variation hotspots. As a faculty member at the University of Virginia (2007-2014), Washington University (2014-2020) and Yale (2020-present), his work has sought to understand the causes and consequences of genome variation in mammals, with an increasing focus on computational methods development and human genetics. His group has developed bioinformatics tools for variant detection, variant interpretation, sequence alignment, data processing, and data integration. He has led genome-wide studies of human genome variation, heritable gene expression variation, human genetic disorders, tumor evolution, mouse strain variation, genome stability in reprogrammed stem cells, and single-neuron somatic mosaicism in the human brain. Dr. Hall's work has been featured in Science Magazine's Breakthrough of the Year (2003 & 2007), the NIMH Director's \"Ten Best of 2013\" and The Scientist (2013), and he has received several prestigious awards including the AAAS Newcomb Cleveland Prize (2003), the Burroughs Wellcome Fund Career Award (2006), the NIH Director's New Innovator Award (2009), and the March of Dimes Basil O'Connor Research Award (2010). He has also served as an Associate Editor at Genome Research (2009-2014) and Genes, Genomes and Genetics (2011-2018).\r\n\r\nMost recently, Dr. Hall has played a leadership role in several large collaborative projects funded by NIH\/NHGRI including the Centers for Common Disease Genomics, the AnVIL cloud-based data repository and analysis platform, and the Human Pangenome Project. His current work is focused on two broad goals: (1) mapping variants and genes that confer risk to human disease, with ongoing projects focused on coronary artery disease and cardiometabolic traits in unique and underrepresented populations, and (2) developing methods for the detection and interpretation of human genome variation, with an emphasis on structural variation and other difficult-to-detect forms, and on comprehensive trait association in human disease studies.", "occurrence_notes":null, "guid":"143396-21893071@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143396", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":null, "has_livestream":0, "cost":"", "tags":["Basic Science","basic sciences","biolgical chemistry","biological chemistry","biological science","Biology","Biosciences","Bsbsigns","cancer","Chemistry","Discussion","epilepsy","Faculty","Free","genetics","genome","genomics","human genetics","Human Genetics, Genetics, Epidemiology","Human Genetics, Genetics, Neurogenetic Diseases","Information and Technology","lecture","Life Science","lifton","Medicine","Natural Sciences","neel","neurological disease","Postdoctoral Research Fellows","Public Health","Public Policy","Reception","research","Science","seminar","sodium channel","symposium"], "website":"https:\/\/medschool.umich.edu\/events?f%5B0%5D=series%3A13266", "sponsors":[ { "group_name":"Department of Human Genetics", "group_id":"1137", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21893071 } , "143398-21893070": { "datetime_modified":"20260107T120553", "datetime_start":"20261012T110000", "datetime_end":"20261012T120000", "has_end_time":1, "date_start":"2026-10-12", "date_end":"2026-10-12", "time_start":"11:00:00", "time_end":"12:00:00", "time_zone":"America\/Detroit", "event_title":"Human Genetics Research Seminar Series", "occurrence_title":"", "combined_title":"Human Genetics Research Seminar Series: presenting Malia Fullerton, DPhil, University of Washington", "event_subtitle":"presenting Malia Fullerton, DPhil, University of Washington", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Monday, October 12, 2026\r\n11:00am - 12:00pm\r\nLocation TBD\r\n\r\nMalia Fullerton, DPhil\r\nAdjunct Professor, Epidemiology\r\nProfessor, Bioethics and Humanities\r\nAdjunct Professor, Genome Sciences\r\nAdjunct Professor, Medicine - Medical Genetics\r\nActing\/Interim Center\/Institute Director, School of Public Health\r\nUniversity of Washington\r\n\u201cSeminar Title TBD\u201d\r\n\r\nHosted By: Wendy R. Uhlmann, Department of Human Genetics\r\n___\r\nStephanie Malia Fullerton, DPhil, is Professor of Bioethics and Humanities at the University of Washington School of Medicine. She is also Adjunct Professor in the UW Departments of Epidemiology, Genome Sciences, and Medicine (Medical Genetics), as well as an affiliate investigator with the Public Health Sciences division of the Fred Hutchinson Cancer Research Center. She received a PhD in Human Population Genetics from the University of Oxford and later re-trained in Ethical, Legal, and Social Implications (ELSI) research with a fellowship from the NIH National Human Genome Research Institute.\r\n\r\nDr. Fullerton\u2019s work focuses on the ethical and social implications of genomic research and its equitable and safe translation for clinical and public health benefit. She serves as the ELSI lead for the Clinical Sequencing Evidence-Generating Research (CSER2) Consortium coordinating center, co-chairs the TOPMed Consortium ELSI Committee, and chairs the Bioethics Advisory Board of the Kaiser Permanente national Research Bank. She contributes to a range of empirical projects focused on clinical genomics translation and precision medicine approaches to the treatment and prevention of cancer and kidney disease in diverse patient populations.", "occurrence_notes":null, "guid":"143398-21893070@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143398", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":null, "has_livestream":0, "cost":"", "tags":["Basic Science","basic sciences","biolgical chemistry","biological chemistry","biological science","Biology","Biosciences","Bsbsigns","cancer","Chemistry","Discussion","epilepsy","Faculty","Free","genetics","genome","genomics","human genetics","Human Genetics, Genetics, Epidemiology","Human Genetics, Genetics, Neurogenetic Diseases","Information and Technology","lecture","Life Science","lifton","Medicine","Natural Sciences","neel","neurological disease","Postdoctoral Research Fellows","Public Health","Public Policy","Reception","research","Science","seminar","sodium channel","symposium"], "website":"https:\/\/medschool.umich.edu\/events?f%5B0%5D=series%3A13266", "sponsors":[ { "group_name":"Department of Human Genetics", "group_id":"1137", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21893070 } }