{ "147495-21901110": { "datetime_modified":"20260407T121357", "datetime_start":"20260422T120000", "datetime_end":"20260422T140000", "has_end_time":1, "date_start":"2026-04-22", "date_end":"2026-04-22", "time_start":"12:00:00", "time_end":"14:00:00", "time_zone":"America\/Detroit", "event_title":"Xiaofeng Dai - Dissertation Defense", "occurrence_title":"", "combined_title":"Xiaofeng Dai - Dissertation Defense: What Does It Feel Like in the Nucleoid? The Biophysical Properties of the Bacterial Chromosome", "event_subtitle":"What Does It Feel Like in the Nucleoid? The Biophysical Properties of the Bacterial Chromosome", "event_type":"Presentation", "event_type_id":"16", "description":"Please join Xiaofeng Dai for their dissertation defense titled \"What Does It Feel Like in the Nucleoid? 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Our laboratory develops fluorescence microscopy methods\u2014including fluorescence intensity and fluorescence lifetime imaging microscopy (FLIM)\u2014to understand chemical reactivity and physical processes in complex reaction media with spatial and temporal resolution. We examine aqueous\u2013organic reactions, oxidative addition to metal powders, and catalytic polymerization. These systems present particular challenges to traditional characterization methods: aqueous\u2013organic emulsions are heterogeneous and optically opaque, organometallic surface intermediates in oxidative\u2013addition reactions do not substantially build up, and many growing polymers are insoluble or spatially heterogenous. In these systems, FLIM reveals object sizes, catalyst localization and environments, the role of reagents, and the physiochemical reasons underpinning catalytic turnover rates. For example, droplet-to-droplet differences in emulsions under cross-coupling conditions suggest that individual droplets function as distinct reaction vessels.", "occurrence_notes":null, "guid":"145683-21897695@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145683", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1200", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry"], "website":"", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, 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"location_name":"Weiser Hall", "has_livestream":0, "cost":"", "tags":["Chemistry","Analytical Chemistry"], "website":"https:\/\/sites.lsa.umich.edu\/asms\/", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21894569 } , "146965-21899887": { "datetime_modified":"20260325T140233", "datetime_start":"20260528T160000", "datetime_end":"20260528T171500", "has_end_time":1, "date_start":"2026-05-28", "date_end":"2026-05-28", "time_start":"16:00:00", "time_end":"17:15:00", "time_zone":"America\/Detroit", "event_title":"Co-Fractionation \u2018Multi-omics\u2019 Mass Spectrometry for Lipid-Protein Interactome Analysis", "occurrence_title":"", "combined_title":"Co-Fractionation \u2018Multi-omics\u2019 Mass Spectrometry for Lipid-Protein Interactome Analysis: Gavin Reid (University of Melbourne)", "event_subtitle":"Gavin Reid (University of Melbourne)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Lipids play essential roles in regulating various biological processes through functional interactions with integral or peripherally associated proteins and protein complexes. While mass spectrometry (MS)-based strategies have enabled global lipidome and proteome identification and quantitative profiling, high-throughput strategies to investigate the lipid-protein \u2018interactome\u2019 at the systems level are currently lacking. Here, I will first describe the development of advanced \u2018shotgun\u2019 lipidomics data acquisition workflows, including the use of ion-mobility for selective enrichment of low abundance lipid classes, and UV-photodissociation MS\/MS to enable complete lipid structural characterisation [e.g., Anal. Chem. 2024, 96, 12296-12307.; Anal. Bioanal. Chem. 2020, 412, 2339\u20132351.], and their application to characterise a novel cause of autosomal regressive multisystem mitochondrial disease resulting from deleterious variants in cardiolipin synthase 1 (CRLS1) [Human Mol. Genetics. 2022, 31, 3597-3612.]. Next, using an integrated \u2018multi-omics\u2019 workflow for comprehensive lipidome and proteome profiling, I will report that the knockout of non-mitochondrial genes in peroxisome, endoplasmic reticulum (ER) and Golgi organelles also results in mitochondrial dysfunction, caused by unexpected alterations in ether-glycerophospholipid metabolic pathways [Nature. Cell Biol. 2024, 26, 57-71]. Finally, to investigate the lipid\u2013protein interaction relationships in these systems, a novel Co-Fractionation Multi-Omics Mass Spectrometry (CF-MOMS) strategy will be described to characterise global alterations in the lipid-protein \u2018interactome interactomes in WT and CRLS1KO cell lines, and to highlight the functional involvement of cardiolipin-protein interactions in maintaining the assembly\/stability and activity of mitochondrial membrane proteins.", "occurrence_notes":null, "guid":"146965-21899887@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/146965", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry","Analytical Chemistry"], "website":"https:\/\/findanexpert.unimelb.edu.au\/profile\/28892-gavin-reid", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21899887 } , "147737-21901667": { "datetime_modified":"20260414T142643", "datetime_start":"20260618T160000", "datetime_end":"20260618T171500", "has_end_time":1, "date_start":"2026-06-18", "date_end":"2026-06-18", "time_start":"16:00:00", "time_end":"17:15:00", "time_zone":"America\/Detroit", "event_title":"CommUNITY Juneteenth Symposium", "occurrence_title":"", "combined_title":"CommUNITY Juneteenth Symposium: Raychelle Burks (American University)", "event_subtitle":"Raychelle Burks (American University)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Title & Abstract TBD", "occurrence_notes":null, "guid":"147737-21901667@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/147737", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry"], "website":"https:\/\/www.american.edu\/cas\/faculty\/burks.cfm", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21901667 } , "142278-21890348": { "datetime_modified":"20251201T105915", "datetime_start":"20260731T090000", "datetime_end":"20260731T170000", "has_end_time":1, "date_start":"2026-07-31", "date_end":"2026-07-31", "time_start":"09:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"2026 CHARMM Developers' Meeting", "occurrence_title":"", "combined_title":"2026 CHARMM Developers' Meeting", "event_subtitle":"", "event_type":"Conference \/ Symposium", "event_type_id":"5", "description":"Dr. Charles L. 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