{ "151930-21912476": { "datetime_modified":"20260928T140340", "datetime_start":"20261020T160000", "datetime_end":"20261020T171500", "has_end_time":1, "date_start":"2026-10-20", "date_end":"2026-10-20", "time_start":"16:00:00", "time_end":"17:15:00", "time_zone":"America\/Detroit", "event_title":"Mechanistic Insights into Metal-Protein Interactions: Implications for Neurodegenerative Disease Progression and Intervention", "occurrence_title":"", "combined_title":"Mechanistic Insights into Metal-Protein Interactions: Implications for Neurodegenerative Disease Progression and Intervention: Katlyn Meier | University of Miami", "event_subtitle":"Katlyn Meier | University of Miami", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Elevated levels of protein expression and aberrant metal exposure have been reported in many neurodegenerative diseases, including Huntington\u2019s Disease (HD). While there is currently no cure for HD, metal chelation therapies have been shown to assuage disease symptoms including chorea. These observations underscore the critical need to understand how metal-protein interactions are involved in disease pathogenesis. Our objective in this work is to elucidate the role of copper (Cu) and other biorelevant metals in HD and, more specifically, their interactions with the huntingtin protein (htt). We aimed to characterize the Cu-htt interaction and speciation trends in our in vitro HD system, as well as the influence of disease-relevant Cu concentrations on protein oligomerization\/aggregation both in vitro and in vivo. We utilized multiple spectroscopic techniques (circular dichroism, electron paramagnetic resonance, UV-Vis absorption, dynamic light scattering, and mass spectrometry) that cover a broad range of energy scales, allowing us to characterize protein structure at the molecular, secondary structure, and quaternary structure levels. Additionally, site-directed mutagenesis of several putative metal binding residues was used to define the roles of specific amino acids in mediating oligomerization\/aggregation, metal binding, and redox chemistry. Taken together, our work has led to the first report of multiple copper binding sites in non-pathological htt and provides insight into one pathway for depletion of native htt pools that may contribute to HD.", "occurrence_notes":null, "guid":"151930-21912476@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/151930", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"CHEM 1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry","Inorganic Chemistry"], "website":"https:\/\/people.miami.edu\/profile\/32b13cd7579d572e6216b4ff90380b5f", "sponsors":[ { "group_name":"Inorganic Chemistry", "group_id":"4387", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21912476 } , "151569-21911776": { "datetime_modified":"20260928T140621", "datetime_start":"20261027T160000", "datetime_end":"20261027T171500", "has_end_time":1, "date_start":"2026-10-27", "date_end":"2026-10-27", "time_start":"16:00:00", "time_end":"17:15:00", "time_zone":"America\/Detroit", "event_title":"Transition Metal Catalyzed Alkylation and Alkenylation of Olefins: New Molecular Catalysts and the Role of Lewis Acidic Oxidants", "occurrence_title":"", "combined_title":"Transition Metal Catalyzed Alkylation and Alkenylation of Olefins: New Molecular Catalysts and the Role of Lewis Acidic Oxidants: Brent Gunnoe | University of Virginia", "event_subtitle":"Brent Gunnoe | University of Virginia", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The selective catalytic functionalization of C\u2013H bonds of hydrocarbons remains one of the foremost challenges facing synthetic chemists. For example, alkyl and alkenyl arenes are produced on a scale of billions of pounds per year. Current commercial catalysts (e.g., Friedel-Crafts or zeolites catalysts) for arene alkylation are based on acid-mediated olefin activation. New catalysts that operate by a distinct reaction pathway that involves transition metal-mediated C\u2013H activation followed by olefin insertion into metal-aryl bonds offer potential advantages. The presentation will focus on the development and study of new transition metal catalysts for arene alkylation and alkenylation based on molecular complexes of Ru, Rh, Pd and Pt with an emphasis on the unexpected role of Cu(II) carboxylates that are used as oxidant.", "occurrence_notes":null, "guid":"151569-21911776@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/151569", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"CHEM 1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry","Inorganic Chemistry"], "website":"https:\/\/gunnoelab.virginia.edu\/?_gl=1*1x7bc70*_ga*MjAxNTc0ODgwMi4xNzg4NTM2OTM3*_ga_68N763636N*czE3ODg1MzY5MzYkbzEkZzAkdDE3ODg1MzY5MzYkajYwJGwwJGgw*_ga_GK1XBTMYM4*czE3ODg1MzY5MzYkbzEkZzAkdDE3ODg1MzY5MzYkajYwJGwwJGgw", "sponsors":[ { "group_name":"Inorganic Chemistry", "group_id":"4387", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", 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"permalink":"http:\/\/events.umich.edu\/event\/152378", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"CHEM 1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry","Inorganic Chemistry"], "website":"https:\/\/chemistry.unm.edu\/people\/faculty\/profile\/martin-kirk.html", "sponsors":[ { "group_name":"Inorganic Chemistry", "group_id":"4387", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21913614 } , "152386-21913622": { "datetime_modified":"20260928T142912", "datetime_start":"20270309T160000", "datetime_end":"20270309T171500", 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