BEGIN:VCALENDAR VERSION:2.0 PRODID:-//UM//UM*Events//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/Detroit TZURL:http://tzurl.org/zoneinfo/America/Detroit X-LIC-LOCATION:America/Detroit BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20070311T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20071104T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTAMP:20221028T061529 DTSTART;TZID=America/Detroit:20230223T160000 DTEND;TZID=America/Detroit:20230223T173000 SUMMARY:Other:Physical Chemistry 3rd Year Seminars DESCRIPTION:Physical\n UID:100322-21799605@events.umich.edu URL:https://events.umich.edu/event/100322 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Chemistry Dow Lab - 1640 CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230120T094943 DTSTART;TZID=America/Detroit:20230224T120000 DTEND;TZID=America/Detroit:20230224T130000 SUMMARY:Workshop / Seminar:MCDB Seminar> How flies get fat: from genes to neurons DESCRIPTION:Host: Laura Buttitta UID:103022-21805718@events.umich.edu URL:https://events.umich.edu/event/103022 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Biological Sciences Building - 1060 CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230206T075933 DTSTART;TZID=America/Detroit:20230227T160000 DTEND;TZID=America/Detroit:20230227T170000 SUMMARY:Lecture / Discussion:RNA Innovation Seminar: Jane Jackman\, OSU DESCRIPTION:HYBRID SEMINAR:\nIn-person: BSRB\, ABC seminar rooms\nzoom: https://umich.zoom.us/webinar/register/WN_WMtC6Sn7T5ic9HbTv9X3BQ UID:97632-21794826@events.umich.edu URL:https://events.umich.edu/event/97632 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Taubman Biomedical Science Research Building - ABC Seminar room CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230109T090420 DTSTART;TZID=America/Detroit:20230228T120000 DTEND;TZID=America/Detroit:20230228T130000 SUMMARY:Workshop / Seminar:Mechanistic Insights into Membrane Signaling Reactions from Reconstitution: A Physical Perspective-Department of Biological Chemistry Seminar Series DESCRIPTION:Dr. Huang will present a seminar in 3330 MS I at 12:00 noon on Tuesday February 28th\, 2023 UID:103036-21805745@events.umich.edu URL:https://events.umich.edu/event/103036 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Medical Science Unit I - 3330 CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230131T102454 DTSTART;TZID=America/Detroit:20230228T160000 DTEND;TZID=America/Detroit:20230228T170000 SUMMARY:Lecture / Discussion:CPOD Seminar: “Principles of tissue dynamics and functions captured by live imaging” Valentina Greco\, PhD (Yale) DESCRIPTION:Tuesday\, February 28\, 2023 4:00 pm\nCenter for Cell Plasticity and Organ Design presents:\n\nValentina Greco\, PhD\nCarolyn Walch Slayman Professor of Genetics\nYale University\nLab Website: http://www.grecolab.org/ \n\n\nSeminar entitled: “Building robust stem cell systems recapitulating human axial patterning and growth”\n\nIn-Person: BSRB ABC Seminar Rooms\nZoom Meeting Option ID: 980 6995 9033\nPass: 2763\n\nFaculty Host: \nPierre A. Coulombe\, Ph.D.\nG. Carl Huber Professor and Chair\nDepartment of Cell and Developmental Biology UID:98540-21808764@events.umich.edu URL:https://events.umich.edu/event/98540 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Off Campus Location CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230228T181511 DTSTART;TZID=America/Detroit:20230228T160000 DTEND;TZID=America/Detroit:20230228T170000 SUMMARY:Other:The multi-dimensionality of microplastics – and how it affects their fate and effects in aquatic ecosystems DESCRIPTION:Microplastic particles are unique from other contaminants in that they are a physical particle composed of a complex mixture of different chemicals (e.g.\, monomers\, additives). In the environment\, they are found in diverse shapes and sizes. These multidimensional characteristics affect their fate in the environment\, and thus exposure in biota. Moreover\, their different characteristics likely affect their impact on ecosystems. This presentation will share results from an in-lake mesocosm experiment conducted at the International Institute for Sustainable Development’s Experimental Lakes Area (IISD-ELA) to discuss the fate of microplastics in aquatic ecosystems. Different concentrations of a mixture of polyethylene\, polystyrene and polyethylene terephthalate were added to nine 10-m diameter x 2-m deep limnocorrals as part of a ten-week experiment to measure the fate and effects of microplastics. The fate of the microplastics influences exposure in biota – relevant to risk. In addition to discussing the work at IISD-ELA\, this presentation will share results from meta-analyses\, and field and lab experiments to discuss the fate of microplastics in food webs and the physical and chemical effects of different types of microplastics across multiple levels of biological organization. Over the last two decades\, the field has matured and we are beginning to understand the contamination\, fate and effects of microplastics. Still\, there is a lot to learn about how their diverse characteristics affect their fate and interactions in ecosystems. \r\n \n \n \n \n \nChelsea Rochman (U-Toronto) UID:95919-21791435@events.umich.edu URL:https://events.umich.edu/event/95919 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Chemistry Dow Lab - 1640 CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230223T113732 DTSTART;TZID=America/Detroit:20230301T090000 DTEND;TZID=America/Detroit:20230301T100000 SUMMARY:Workshop / Seminar:Microbiome Seminar: Pinpointing Metabolite Cross Feeding Interactions in Microbial Communities using 13C Metabolic Flux Analysis Maciek DESCRIPTION:Speaker: Maciek R. Antoniewicz\, PhD\nProfessor of Chemical Engineering\nUniversity of Michigan\nMaciek Antoniewicz \n\nHost: Thomas Schmidt\, Ph.D.\nTom Schmidt \n\nThe Antoniewicz laboratory for Metabolic Engineering and Systems Biology develops next generation tools and techniques for analyzing\, engineering and manipulating microbial and mammalian systems applied to specific problems in biotechnology and medicine.\n\nMaciek R. Antoniewicz is a Full Professor of Chemical Engineering at the University of Michigan. Dr. Antoniewicz earned his B.S. and M.S. degrees in Chemical Engineering from Delft University of Technology (2000)\, and his Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology (2006). After graduating he performed post-doctoral research at the DuPont Company. Dr. Antoniewicz started as an Assistant Professor in 2007 at the University of Delaware and was promoted to Associate Professor in 2013 and to Full Professor in 2017. In 2019\, Dr. Antoniewicz moved to the University of Michigan.\n\nDr. Antoniewicz is an expert and a pioneer in the field of 13C-metabolic flux analysis (13C-MFA). Dr. Antoniewicz has received many awards for his research accomplishments\, including the DuPont Young Professor Award (2008)\, the James E. Bailey Young Investigator Award in Metabolic Engineering (2008)\, the NSF CAREER Award (2011)\, and the Biotechnology and Bioengineering Daniel I.C. Wang Award (2015). In 2018\, Dr. Antoniewicz was elected as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE). His current interests include elucidating syntrophic interactions in microbial communities\, adaptive laboratory evolution\, optimizing CHO cell cultures for therapeutic protein production\, and metabolic engineering of microbes for enhanced utilization of renewable substrates for production of value-added chemicals.\n\nAbstract\n\nOne of the most important and difficult to quantify interactions in microbial communities is the cross-feeding of nutrients between community members. Experimental approaches that are based on metabolic measurements cannot precisely identify which metabolites are exchanged between community members. To address this challenge\, we have developed a 13C-metabolic flux analysis technique that can precisely pinpoint exact metabolite that are being cross-fed. In this presentation\, I will demonstrate applications of our new 13C-flux analysis approach to elucidate metabolite exchanges in several microbial co-cultures. To determine which metabolites are cross-fed (and at what rates)\, cells are cultured in parallel in the presence of carefully selected isotopic tracers. Isotopic labeling is then measured by mass spectrometry and the data is then analyzed using our new 13C-flux analysis approach. Using statistical methods\, we can then precisely identify what metabolites are exchanged by the different strains\, in which direction the cross-feeding occurs\, and what the rates are for these cross-feeding fluxes. As an example\, in E. coli co-cultures we identified nine metabolites that are consistently cross-fed. These include organic acids\, intermediates of the glycolysis pathway\, intermediates of the citric acid cycle\, and some (but not all) amino acids. To verify these predictions\, additional 13C-tracer experiments were conducted and complemented with 13C exo-metabolomic measurements. Taken together\, these examples demonstrate that our new analysis techniques can significantly improve our understanding of metabolic interactions in microbial communities (which cannot be resolved with current approaches)\, and in the future will enable rational engineering of microbial interactions and assembly of microbiomes for practical applications in medicine and biotechnology.\n\nJoin Zoom Meeting: https://umich.zoom.us/j/97404167107\, no passcode\, waiting room UID:105371-21811619@events.umich.edu URL:https://events.umich.edu/event/105371 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Off Campus Location CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230223T115655 DTSTART;TZID=America/Detroit:20230301T140000 DTEND;TZID=America/Detroit:20230301T150000 SUMMARY:Workshop / Seminar:MCDB Seminar> Deciphering Microbial-Immune Relationships in the Airways: Insights from Computational Approaches DESCRIPTION:Host: Gary Huffnagle\nThis has been rescheduled to March 1. UID:105051-21811622@events.umich.edu URL:https://events.umich.edu/event/105051 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Biological Sciences Building - 1010 CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230305T231828 DTSTART;TZID=America/Detroit:20230305T230000 SUMMARY:Workshop / Seminar:Microbial regulation of animal insulin signaling: From effects to mechanisms DESCRIPTION:Location\nHybrid:\n\nIn-person: Medical Science 2\, Room 5623\n\nor \n\nVirtual: https://umich.zoom.us/j/91267980290 \n\nAbstract:\n\nMicrobiomes have been proposed to regulate many aspects of animal physiology and dysregulated microbiomes are known to contribute to numerous pathologies in humans. Despite these findings\, many of the molecular mechanisms by which bacteria can influence host physiology remain unknown. In an effort to identify novel molecular mechanisms by which bacteria can promote normal animal physiology my lab has established a high-throughput screening platform using the model animal C. elegans that can screen 1\,500 individual bacterial isolates per week for effects on animal physiology. Using this platform\, we have now identified multiple new species of bacteria that restore normal physiology in mutant models of human disease. Furthermore\, using transposon screening\, we have begun to uncover some of the mechanisms bacteria use to mediate these effects on animals. In the long-term we aim to test if such mechanisms are evolutionarily conserved in bacteria that colonize human microbiomes or if such mechanisms can be adapted to treat human disease. \n\nBIOGRAPHY:\n\nDr. Nick Burton explores how chromatin remodeling contributes to human disease and how a person’s environment can impact their health and the health of their offspring. Recently\, this work has become particularly interested in the diverse ways microbes and the microbiome can influence these processes. He earned a B.S. in biology from University of Wisconsin-Madison\, where he worked in the labs of both Dr. Anna Huttenlocher and Dr. Scott Kennedy. He was then awarded a graduate research fellowship from the National Science Foundation (NSF) and earned a Ph.D. in biology from Massachusetts Institute of Technology\, where he studied under the mentorship of Dr. H. Robert Horvitz. As part of his dissertation work\, Dr. Burton sought to develop new paradigms to study the mechanisms by which parental environment regulates offspring physiology. In 2017\, he joined the Centre for Trophoblast Research at University of Cambridge as an independent Next Generation Fellow. While there\, he investigated how environmental bacteria can affect development\, physiology\, metabolism and neuronal function of individuals and their offspring. In 2021\, he joined Van Andel Institute as an assistant professor in the Department of Epigenetics.\n\n(Area of expertise: Epigenetics\, intergenerational inheritance\, C. elegans\, metabolism\, host-microbe interactions) UID:105773-21812930@events.umich.edu URL:https://events.umich.edu/event/105773 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Off Campus Location CONTACT: END:VEVENT BEGIN:VEVENT DTSTAMP:20230219T182816 DTSTART;TZID=America/Detroit:20230306T090000 DTEND;TZID=America/Detroit:20230306T100000 SUMMARY:Lecture / Discussion:Novel Protamine Biology and its Regulatory Mechanisms in Drosophila Spermatogenesis DESCRIPTION:Dissertation Seminar\n\nWe are pleased to announce that Jun Park\, Ph.D.\, Candidate will present his Dissertation Defense titled \"Novel Protamine Biology and its Regulatory Mechanisms in Drosophila Spermatogenesis\" on Monday\, March 6\, 2023 from 9-10:00 a.m.\, via live stream: Livestream: https://umich.zoom.us/j/93865614370\, and in Person at BSRB Kahn Auditorium.\n\nHosted by:\nBing Ye\, Ph.D. (Chair)\nYukiko Yamashita\, Ph.D. (Mentor)\nScott Barolo\, Ph.D.\nSue Hammoud\, Ph.D.\nJacob Mueller\, Ph.D.\nSwathi Yadlapalli\, Ph.D. UID:105045-21810643@events.umich.edu URL:https://events.umich.edu/event/105045 CLASS:PUBLIC STATUS:CONFIRMED CATEGORIES:Biosciences LOCATION:Taubman Biomedical Science Research Building - Kahn Auditorium CONTACT: END:VEVENT END:VCALENDAR