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DTSTAMP:20220726T130939
DTSTART;TZID=America/Detroit:20220729T100000
DTEND;TZID=America/Detroit:20220729T110000
SUMMARY:Lecture / Discussion:Discovery and Development of Agonist Antibodies for T Cell Receptors
DESCRIPTION:Agonist antibodies that activate co-stimulatory immune receptors\, such as the tumor necrosis factor (TNF) receptors OX40 and CD137\, are an important class of emerging therapeutics due to their ability to regulate immune cell activity. Despite their promise\, there are no approved agonist antibodies for treating cancer as demonstrated by previous unsuccessful clinical trials. Although multiple factors are responsible for poor clinical efficacy\, one major bottleneck is the reliance on FcγR-mediated crosslinking for sufficient receptor activation. This is inherently problematic because FcγR expression varies greatly on different immune cells\, leading to a wide range of receptor agonism. Emerging research suggests that antibodies engaging two different epitopes on the same immune receptor mediate receptor superclustering and enable robust antibody agonism without extrinsic Fc crosslinking. However\, there are no systematic methods for identifying such biepitopic (also known as biparatopic) agonist antibodies. Therefore\, the objective of this research work is to develop facile methods for reliably identifying biepitopic antibodies to activate immune receptors for immunotherapeutic applications.\n\nBiepitopic antibodies have been shown to mediate potent receptor activation for a variety of immune receptors. Traditionally\, the generation of these antibodies requires key steps including animal immunization\, epitope binning to identify unique antibody pairs\, and combining antibody pairs to engineer biepitopic antibodies. While this approach has been used to successfully discover biepitopic antibodies\, it suffers from key limitations. Notably\, animal immunization and subsequent antibody isolation is an arduous and unpredictable process. Even when successful clones are discovered from these processes\, further epitope binning experiments are needed to select antibody pairs to discover potent immune therapeutics. To overcome these limitations\, we developed an antibody screening strategy that greatly simplifies the discovery of biepitopic antibodies. Our approach eliminates the need for animal immunization by using existing\, off-the-shelf IgG antibodies specific to the target receptor. Next\, we perform in vitro selections by blocking the receptor epitope of the existing antibody and conducting subsequent sorts to identify single-chain antibodies with orthogonal binding domains. Thus far\, our work has shown that the antibody screening strategy can be used to discover antibodies for a variety of TNF receptors including OX40 and CD137.\n\nGiven that receptor clustering of three or more receptors is critical for activating TNF receptors\, we first generated biepitopic tetravalent OX40 antibodies by attaching novel single-chain antibodies to the C-termini of the light chain of existing clinical-stage antibodies. These tetravalent biepitopic antibodies showed remarkable T cell proliferation and cytokine secretion for biepitopic antibodies compared to their monoepitopic counterparts. Next\, we sought to improve the additional clinical-stage OX40 IgGs engineered as biepitopic antibodies to show the generality of our findings that biepitopic antibodies can mediate superior and FcγR-independent activities. Beyond OX40 IgGs\, we also show that biepitopic antibodies can be used to mediate superior T cell proliferation for other TNF receptors including CD137. Looking forward\, we anticipate that these research advancements will accelerate the discovery and development of the next generation of immune therapeutics.\n\nDate: Friday\, July 29\, 2022\nTime: 10:00 AM\nZoom: https://umich.zoom.us/j/5163583658\nCo-Chairs: Professors Peter Tessier and Lonnie Shea
UID:96254-21792188@events.umich.edu
URL:https://events.umich.edu/event/96254
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,biomedical,biomedical engineering,Biosciences,bme,engineering,Life Science,Medicine,Michigan Engineering,Science
LOCATION:Off Campus Location
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20220813T063106
DTSTART;TZID=America/Detroit:20220729T110000
DTEND;TZID=America/Detroit:20220729T120000
SUMMARY:Careers / Jobs:ScribeAmerica Virtual Information Session July 29th
DESCRIPTION:Are you looking at a future career in healthcare and need clinical experience? If so join us for our upcoming virtual info session to learn more about our medical scribe positions!\n\nIf you're not able to attend this session please use the link above to view additional session in July.
UID:95912-21791428@events.umich.edu
URL:https://events.umich.edu/event/95912
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20220519T125817
DTSTART;TZID=America/Detroit:20220729T110000
DTEND;TZID=America/Detroit:20220729T120000
SUMMARY:Class / Instruction:Summer Institute in Survey Research Techniques
DESCRIPTION:Open for registration!\n\nThe Summer Institute offers courses on (1) research design and sample selection\, (2) measurement\, (3) qualitative methods in survey research design\, (4) data collection\, and (5) analysis.\n\nMulti-week courses provide more in-depth coverage of a topic\, include readings\, homework\, and examinations\, and often providing participants with an opportunity to practice survey techniques.  One-week courses give an overview of a methodology topic\, including readings and homework.  One-day workshops are offered for those who need to learn a specific technique or method in a short period of time.\n\nAll 2022 courses will be offered in an alternative remote format.
UID:95200-21788808@events.umich.edu
URL:https://events.umich.edu/event/95200
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,Career,Corporate,Economics,Graduate,Graduate Students,Information and Technology,International,Kinesiology,Mathematics,Professional Development,Psychology,Public Policy,Research,Science,Sociology,Training
LOCATION:Off Campus Location
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20260112T144046
DTSTART;TZID=America/Detroit:20220729T120000
DTEND;TZID=America/Detroit:20220729T123000
SUMMARY:Well-being:Heartfulness Guided Meditation
DESCRIPTION:Heartfulness Guided Meditation is a weekly\, drop-in program designed to help you Mental well-being. \n\nAll U-M students\, faculty\, and staff are welcome to participate in guided meditation practice with a trainer every Friday at noon over Zoom (details to join are provided below). No prior experience with meditation is required. \n\n*What will you learn?*\n\nThe guided meditation practice involves three simple steps: relaxation\, rejuvenation\, and meditation.\n\nRelaxation brings your body to a calm\, steady posture creating a stillness at the physical level\, and prepares the mind for meditation. We follow this with a rejuvenation method to detox the mind to let go of stress and complex emotions\, and will leave you feeling light and refreshed. Lastly\, learning to meditate by being mindful of your heart will connect you with yourself by listening to your heart’s voice. \n\n*Why Meditate?*\n\nWhile physical fitness keeps our bodies in shape\, meditation is an exercise for the mind and mental wellness. In addition to the measurable benefits mentally and physically\, many people benefit from an unquantifiable inner poise and harmony. \n\n*Please take Learn to Meditate session if you are new to the practice. These sessions are offered Monthly.* https://events.umich.edu/event/128708\n\n*Event Details*\n\nHeartfulness Guided Meditation \nFridays from 12-12:30 p.m. ET (except during university season days / holidays)\nJoin Via Zoom Meeting\nRegister to receive Passcode (see “Related links”\n\n\nThis wellness program is coordinated by ITS Teaching & Learning and provided at no cost by heartfulness.org.
UID:88544-21791389@events.umich.edu
URL:https://events.umich.edu/event/88544
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Free,Health & Wellness,Well-being
LOCATION:Off Campus Location
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20220607T113326
DTSTART;TZID=America/Detroit:20220729T120000
DTEND;TZID=America/Detroit:20220729T130000
SUMMARY:Workshop / Seminar:MCDB Seminar> Discovering Chemical Probes of DNAJB6: A Novel Target for Polyglutamine Diseases
DESCRIPTION:Host: Anuj Kumar
UID:95306-21789142@events.umich.edu
URL:https://events.umich.edu/event/95306
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,Biosciences,Bsbsigns,Natural Sciences,Research,Science
LOCATION:Biological Sciences Building - 1060
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20220911T180007
DTSTART;TZID=America/Detroit:20220729T120000
DTEND;TZID=America/Detroit:20220729T235959
SUMMARY:Auditions:Spring Awakening Auditions Due!
DESCRIPTION:Interested in performing in Spring Awakening at the Arthur Miller Theatre? Go ahead and send in an audition to our audition form by 11:59pm on Sunday\, September 11!
UID:96360-21792305@events.umich.edu
URL:https://events.umich.edu/event/96360
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:Online
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20220813T063100
DTSTART;TZID=America/Detroit:20220729T120000
DTEND;TZID=America/Detroit:20220729T163000
SUMMARY:Careers / Jobs:Vanguard Virtual Investment Management EXPLORE Day
DESCRIPTION:Join us for Vanguard's Virtual Investment Management EXPLORE Day on July 29th from 1:00-4:00 PM EST! This event is for First\, Second\, and Third-year students who are looking to pursue a career with an organization that is changing the way the world invests. Together\, we make it count.\n\nStudents of all majors who are interested in learning about our meaningful career opportunities in Investment Management are encouraged to apply.\n\nThe final day to apply is Friday\, July 1st at 11:59 PM EST. Click here to access the event application: https://vanguard.recsolu.com/app/collect/event/yVPT7YEAKIVGjdeib84Ypw\n\nWhat does a career in Investment Management at Vanguard look like? At this event\, you will have the opportunity to:\n\n- Gain exposure to our business and corporate environment\n- Meet our Investment Management leaders and professionals\n- Hear from recentgraduates and learn about our Investment Management opportunities\n- Participate in professional development activities that will set you up for anambitious career
UID:95416-21789903@events.umich.edu
URL:https://events.umich.edu/event/95416
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20220613T111638
DTSTART;TZID=America/Detroit:20220729T123000
DTEND;TZID=America/Detroit:20220729T131500
SUMMARY:Presentation:Expedition Reef
DESCRIPTION:Learn the secrets of the “rainforests of the sea” as you embark on an oceanic safari of the world’s most vibrant—and endangered—marine ecosystems. Expedition Reef immerses you in an undersea adventure. Along the way\, discover how corals grow\, feed\, reproduce\, and support over 25% of all marine life on Earth.
UID:89011-21790341@events.umich.edu
URL:https://events.umich.edu/event/89011
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Astronomy,Museum,natural history museum
LOCATION:Museum of Natural History
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20220912T132709
DTSTART;TZID=America/Detroit:20220729T143000
DTEND;TZID=America/Detroit:20220729T151500
SUMMARY:Presentation:Tales of the Maya Skies
DESCRIPTION:Tales of the Maya Skies immerses viewers in the wonders of Maya science\, cosmology and myth. This beautifully illustrated story takes us back in time to the jungles of Mexico to discover how Mayan scholars developed a sophisticated understanding of astronomy\, architecture\, and mathematics that enabled them to predict solstices\, solar eclipses\, weather patterns and planetary movements.\n\nThe state-of-the-art Planetarium & Dome Theater at the U-M Museum of Natural History transports visitors beyond distant stars and back in time from the comfort of reclining seats. Tickets $8. Tickets are available on the day of the show at the Museum Store.\n\nThe planetarium is operating at half capacity to maximize distancing between viewers.
UID:95036-21790311@events.umich.edu
URL:https://events.umich.edu/event/95036
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Astronomy,Museum,Natural Sciences,Science
LOCATION:Museum of Natural History
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20220719T183524
DTSTART;TZID=America/Detroit:20220729T170000
DTEND;TZID=America/Detroit:20220729T180000
SUMMARY:Social / Informal Gathering:FYE Summer Series: Taking Care of Maize & You
DESCRIPTION:Are you looking to meet new people and connect with others? Join us for some fun focused on self-care and community building! We’ll practice self-care strategies\, participate in a gratitude scavenger hunt\, and play virtual games!
UID:96148-21791964@events.umich.edu
URL:https://events.umich.edu/event/96148
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Free,Virtual,Workshop
LOCATION:Off Campus Location
CONTACT:
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