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DTSTAMP:20240620T181506
DTSTART;TZID=America/Detroit:20250418T110200
DTEND;TZID=America/Detroit:20250418T170000
SUMMARY:Exhibition:Michelle Hinojosa: Logcabins
DESCRIPTION:Stamps Gallery commissioned Michelle Hinojosa (MFA\, 2023) to reimagine the pillars on Division Street that flank the Gallery. Hinojosa has created log cabin quilts to adorn the columns in front of Stamps Gallery. The log cabin quilts traditionally represent the warm hearth at the center of a home. This installation reflects on the interplay between home\, placemaking\, labor\, and intergenerational memories of migration. Rather than quilting cotton designed to softly embrace the body\, these quilts are sewn from outdoor grade\, UV-resistant polyester. The quilt is an ode to Hinojosa’s grandmother who illegally crossed the US/Mexico border holding her babies and her quilts. As she and her family drove across the United States to work in the fields of the Salinas Valley\, the quilts offered a safe space for her and her family. Hinojosa celebrates their resilience to her grandmother and elders while also drawing attention to precarity and violence experienced by refugees and migrants crossing the US-Mexico border in our present today.\nArtist’s bio:\nMichelle Inez Hinojosa is an artist\, educator\, and researcher whose work is informed by Indigenous and Latine/x/a/o studies. Born and raised in Texas\, she earned her Bachelor of Fine Arts degree in both drawing and painting and art education with a minor in art history at the University of North Texas. She holds a Master of Fine Arts from the University of Michigan. She works with quilting\, bead weaving\, embroidery\, jewelry\, transparent film installations\, painting\, ceramics\, and sculpture to honor and explore the history of migration in her family and humanize the current discourse around migration still occurring at the southern border. Alongside her artwork she maintains a writing practice to re-story\, re-make\, and re-claim the often subordinated narratives of Latinx\, Chicanx\, Mexican\, and Texican peoples. \n\nRecently\, Hinojosa was named an inaugural Creative Careers Artist in Residence at the University of Michigan\, she has also attended residencies at Mildred's Lane (Pennsylvania)\, Anderson Ranch Art Center (Aspen\, CO) and The Cedars Union (Dallas\, TX). 
UID:122384-21848876@events.umich.edu
URL:https://events.umich.edu/event/122384
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Art
LOCATION:Off Campus Location
CONTACT:
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DTSTAMP:20250320T163633
DTSTART;TZID=America/Detroit:20250418T120000
SUMMARY:Workshop / Seminar:A cross-century pursuit of propagating waves of cell death
DESCRIPTION:Large-scale cell death is commonly observed during organismal development and in human pathologies. These cell death events extend over great distances to eliminate large populations of cells\, raising the question of how cell death can be coordinated in space and time. One mechanism that enables long-range signal transmission is trigger waves\, but how this mechanism might be used for death events in cell populations remains unclear. Here we demonstrate that ferroptosis\, an iron- and lipid-peroxidation-dependent form of cell death\, can propagate across human cells over long distances (≥ 5 mm) at constant speeds (around 5.5 μm/min) through trigger waves of reactive oxygen species (ROS). Chemical and genetic perturbations indicate a primary role of ROS feedback loops (Fenton reaction\, NADPH oxidase signaling and glutathione synthesis) in controlling the progression of ferroptotic trigger waves. We show that introducing ferroptotic stress through suppression of cystine uptake activates these ROS feedback loops\, converting cellular redox systems from being monostable to being bistable and thereby priming cell populations to become bistable media over which ROS propagate. Furthermore\, we demonstrate that ferroptosis and its propagation accompany the massive\, yet spatially restricted\, cell death events during muscle remodeling of the embryonic avian limb\, substantiating its use as a tissue-sculpting strategy during embryogenesis. Our findings highlight the role of ferroptosis in coordinating global cell death events\, providing a paradigm for investigating large-scale cell death in embryonic development and human pathologies.
UID:128871-21861721@events.umich.edu
URL:https://events.umich.edu/event/128871
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biophysics
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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