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DTSTAMP:20250929T154847
DTSTART;TZID=America/Detroit:20251009T120000
DTEND;TZID=America/Detroit:20251009T130000
SUMMARY:Workshop / Seminar:Tools and Technology Seminar by Michelle Kim
DESCRIPTION:Abstract\n\nUnderstanding the genetic basis of complex traits in admixed populations is challenging due to diverse genetic backgrounds\, particularly for highly prevalent diseases. Misinterpreting admixture’s impact can have significant consequences for biomedical research. This study employs advanced computational biology to investigate how admixture shapes the genetic architecture of complex traits and influences GWAS outcomes. Using the forward-in-time population genetic simulator SLiM\, we model trait evolution under admixture by varying the relationship between causal variant effect sizes and selection coefficients while accounting for population size changes and migration across five admixture scenarios. \n\nOur findings reveal that GWAS power is influenced by genetic architecture and population demographic history. Traits with weak correlations between effect size and fitness (e.g.\, anthropometric traits) show higher GWAS power compared to traits with stronger correlations (e.g.\, genetic diseases). Populations with recent bottlenecks exhibit higher GWAS power\, highlighting the role of rare variants. Surprisingly\, fine- mapping ability remains consistent across traits. Empirical validation using data from diverse populations\, including the All of Us database\, supports our simulation predictions. For anthropometric traits like height\, common variants exhibit moderate effects\, while for traits like malignant neoplasms\, rare variants show larger effects and common variants minimal effects. \n\nBy integrating population and complex trait genetics\, this study provides insights into how population history shapes genetic architecture and heritability. Our findings improve understanding of genetic studies in diverse populations\, enabling more accurate biomedical applications and personalized medicine strategies. \n\nAbout The Tools & Technology Seminar Series\n\nThe DCMB Tools and Technology Seminar Series is held in Palmer Commons\, Room 2036\, each Thursday at 12pm EST. Each seminar highlights a computational tool\, technology\, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.\n\nThese seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel.
UID:140029-21886500@events.umich.edu
URL:https://events.umich.edu/event/140029
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Bioinformatics,Information and Technology,Biosciences,Basic Science
LOCATION:Palmer Commons - 2036
CONTACT:
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DTSTAMP:20250910T133959
DTSTART;TZID=America/Detroit:20251009T120000
DTEND;TZID=America/Detroit:20251009T150000
SUMMARY:Well-being:U-M Farm Stand
DESCRIPTION:New location\, same Farm Stand! Join the U-M Sustainable Food Program (SL Sustainability) and the Campus Farm (Matthaei Botanical Gardens) every Thursday from 12-3pm to get produce grown by students for students. While the Diag is under construction\, the Farm Stand will park just west of the North University Building. As always\, students get a 30% discount and revenue from the Farm Stand will support the Student Food Empowerment Fund\, which offers grants to students and student organizations to pursue student-powered sustainable food projects on and off-campus.
UID:137707-21880605@events.umich.edu
URL:https://events.umich.edu/event/137707
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:campus farm,Well-being,Sustainability,Food Justice,food
LOCATION:1100 North University Building
CONTACT:
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