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DTSTART:20070311T020000
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BEGIN:VEVENT
DTSTAMP:20241023T123210
DTSTART;TZID=America/Detroit:20241008T153000
DTEND;TZID=America/Detroit:20241008T163000
SUMMARY:Careers / Jobs:Kick It With Nike Inc.\, Information Session (Grad)
DESCRIPTION:Learn more about Nike\, Inc. and all our available internship opportunities! To be eligible\, students must have a graduation date ofWinter 2025 or Spring 2026.
UID:126150-21856601@events.umich.edu
URL:https://events.umich.edu/event/126150
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
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DTSTAMP:20240912T140631
DTSTART;TZID=America/Detroit:20241008T160000
SUMMARY:Workshop / Seminar:Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis
DESCRIPTION:The increasing prevalence of antimicrobial resistance is an important challenge that warrants new approaches to antibiotic development. Currently\, all antibiotics inhibit biological processes. To explore whether activation of a biochemical pathway can elicit bactericidal effects we engineered variants of Mycobacterium tuberculosis ATP-phosphoribosyltransferase (ATP-PRT) that are resistant to allosteric inhibition by L-histidine\, leading to supraphysiological activation of ATP-PRT and L-histidine overproduction. Upregulation of L-histidine biosynthesis significantly reduces the growth of M. tuberculosis in culture and causes a loss of fitness owing to nutrient and energy depletion. Moreover\, the expression of allosteric variants in M. tuberculosis significantly reduced infections in human macrophages and in a mouse model of infection. Thus\, metabolic activation is a new bactericidal mechanism that could be applied to antibiotic discovery more generally.
UID:125060-21854307@events.umich.edu
URL:https://events.umich.edu/event/125060
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Chemical Biology,Chemistry
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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