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DTSTAMP:20240827T112246
DTSTART;TZID=America/Detroit:20240829T160000
SUMMARY:Workshop / Seminar:Spectroscopic studies of nucleic acid structure\, dynamics and photophysics
DESCRIPTION:RNA performs a diverse set of biological functions\, many of which require it to fold into specific structures. Many techniques have been developed to study RNA folding\, a number of which are based on fluorescence detection. I will present work in which we used fluorescent analogues of the natural RNA bases to selectively probe the structures of different conformational subpopulations of RNA. We investigated the photophysical properties of base analogues in different structural contexts using a combination of time-resolved fluorescence measurements and fluorescence-detected circular dichroism spectroscopy\, which circumvents the ensemble averaging that typically limits the power of bulk spectroscopic methods such as CD. Ensemble averaging can also be avoided by performing measurements on single molecules. I will present work in which we utilized single-molecule microscopy to investigate the ensemble of structures adopted by RNA \"switches\". These studies reveal how the 3D structure of RNA is impacted by intrinsic factors such as base sequence and extrinsic factors such as the binding of small molecules.
UID:125052-21854297@events.umich.edu
URL:https://events.umich.edu/event/125052
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Chemistry,Physical Chemistry
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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DTSTAMP:20240820T125248
DTSTART;TZID=America/Detroit:20240829T163000
DTEND;TZID=America/Detroit:20240829T173000
SUMMARY:Social / Informal Gathering:Computing in LSA: An Ice Cream Info-Social
DESCRIPTION:Thursday\, August 29th\; 4:30pm to 5:30pm\; 1140 &1160 USB\n\nPlease join us for a welcome back event\, with sundaes\, information and swag!\n\n- Learn about computing options across LSA\n- Meet computing education faculty\n- Mingle with peers\, make new friends\n- Build a sundae\n- Get swag\n\nQuestions? Please contact pcas.events@umich.edu
UID:124602-21853305@events.umich.edu
URL:https://events.umich.edu/event/124602
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Information and Technology,Social,Undergraduate,Welcome to Michigan
LOCATION:Undergraduate Science Building - 1140
CONTACT:
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