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DTSTAMP:20260107T120530
DTSTART;TZID=America/Detroit:20260914T110000
DTEND;TZID=America/Detroit:20260914T120000
SUMMARY:Lecture / Discussion:Human Genetics Research Seminar Series
DESCRIPTION:Monday\, September 14\, 2026\n11:00am - 12:00pm\nLocation TBD\n\nYang Shi\, PhD\nProfessor of Epigenetics\nLudwig Institute for Cancer Research\nOxford University\, Oxford\, England\n“Seminar Title TBD”\n\nHosted By: Shigeki Iwase\, PhD\, Department of Human Genetics\n___\nBefore joining Ludwig Oxford in 2020\, I was Professor of Cell Biology and C. H. Waddington Professor of Pediatrics at Harvard Medical School. I received my PhD from New York University and postdoctoral training at Princeton University. I joined Harvard Medical School as an Assistant Professor in 1991 and was appointed a Professor of Pathology in 2004. In 2009 I joined the Newborn Medicine Division of Boston Children’s Hospital.\n\nI am interested in identifying key epigenetic regulators in cancer\, elucidating their mechanism of action and providing the conceptual basis for translating our basic findings to the clinic via the development of new therapeutic strategies. With the discovery of the first histone methyl eraser\, LSD1\, in 2004\, our group demonstrated that histone methylation is dynamically regulated\, which overturned the long-held dogma that such modifications were static and irreversible. We have also discovered many additional histone demethylases with different specificities\, and novel readers\, including those that specifically recognize unmodified lysine and arginine and suggest that the unmodified states are not simply a ground neutral state of epigenetic information but rather likely code for epigenetic information as modified states. Importantly\, many of these chromatin enzymes and readers have since been implicated in various types of human cancers\, indicating an important role of chromatin regulation in tumorigenesis.\n\nMore recently\, we have also been studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology\, i.e.\, the nature and the biological and pathological functions of RNA modifications\, as well as the enzymes responsible for writing\, erasing and reading them\, are just beginning to be understood.\n\nAt Ludwig Oxford\, my lab is focusing on two questions. First\, how to convert “cold tumors to “hot” and how to sustain durable responses to cancer immune checkpoint blockade therapy. Second\, how to induce therapeutic differentiation of cancers\, using acute myeloid leukemia and diffuse intrinsic pontine glioma as models where chromatin/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state.
UID:143395-21893072@events.umich.edu
URL:https://events.umich.edu/event/143395
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Postdoctoral Research Fellows,Human Genetics\, Genetics\, Neurogenetic Diseases,Information and Technology,lecture,Life Science,lifton,Medicine,Natural Sciences,neel,neurological disease,basic sciences,Public Health,Public Policy,Reception,research,Science,seminar,sodium channel,symposium,human genetics,Basic Science,biolgical chemistry,biological chemistry,biological science,Biology,Biosciences,Bsbsigns,cancer,Chemistry,Discussion,epilepsy,Faculty,Free,genetics,genome,genomics,Human Genetics\, Genetics\, Epidemiology
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DTSTAMP:20260912T022129
DTSTART;TZID=America/Detroit:20260914T110000
DTEND;TZID=America/Detroit:20260914T120000
SUMMARY:Workshop / Seminar:Wolverine Village Residence Hall Community Tours
DESCRIPTION:Michigan Housing is excited to welcome members of the University of Michigan and Ann Arbor community for an opportunity to tour Wolverine Village.This year marks the most students to live on-campus within Michigan Housing in U-M history with the grand opening of Wolverine Village\, the university’s newest 2\,300 bed and 800+ seat dining hall residential community. Formerly known as the Central Campus Residential Development\, Wolverine Village is a new five-building residential community on U-M’s Central Campus and adjacent to the athletic campus.Daily tours will highlight Wolverine Village and its residence halls\, gathering spaces\, and community art.Wolverine Village tours are open to the public and registration is required. Tour capacity is limited while Wolverine Village residence halls are occupied by the U-M student community. Additional tour dates may be added if demand allows for it.\nFor tour questions\, please reach out to the Michigan Housing team at wolverinevillagetours@umich.edu.
UID:150340-21909039@events.umich.edu
URL:https://events.umich.edu/event/150340
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Wolverine Village
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