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DTSTAMP:20260303T145140
DTSTART;TZID=America/Detroit:20260318T160000
DTEND;TZID=America/Detroit:20260318T170000
SUMMARY:Workshop / Seminar:CCMB/DCMB Weekly Seminar Series featuring Li-San Wang\, PhD (Associate Dean for Computing\, Perelman School of Medicine)
DESCRIPTION:Abstract\nLarge-scale human genetics has transformed Alzheimer’s disease (AD) research. Through coordinated efforts such as the Alzheimer’s Disease Genetics Consortium (ADGC) and the Alzheimer’s Disease Sequencing Project (ADSP)\, dozens of reproducible risk loci have been identified across diverse populations. ADSP is now generating whole-genome sequence data at unprecedented scale\, with an eventual goal of 150\,000 genomes integrated with harmonized clinical and functional datasets. As data generation accelerates\, interpretation of genetic discoveries has become the central bottleneck.\n\nIn this seminar\, I will present computational frameworks developed within ADSP to bridge the gap between association and mechanism. These include multi-ancestry meta-analysis and fine-mapping approaches that leverage linkage disequilibrium differences to refine credible sets\; integration of rare and structural variants within joint-calling pipelines\; and colocalization strategies incorporating eQTL and other quantitative trait locus datasets to prioritize target genes. I will also discuss regulatory annotation tools such as INFERNO and BTS that integrate large collections of functional genomic tracks for context-specific variant interpretation\, along with the informatics infrastructure developed within the NIA Genetics of Alzheimer’s Disease Data Storage Site to support genome production\, quality control\, phenotype harmonization\, and scalable coordination across more than 50\,000 whole genomes. Together\, these efforts illustrate how statistical genetics\, functional genomics\, and production-scale bioinformatics infrastructure can be integrated to advance mechanistic understanding of complex neurodegenerative disease. \n\nThe CCMB Seminar Series (Sponsored by DCMB) is held at Medical Science Unit I - 4B700\, each Wednesday\, at 4:00 pm EST\, on bioinformatics-related topics. Each seminar is presented by an invited guest speaker. These seminars are live-streamed on Zoom.
UID:143694-21893657@events.umich.edu
URL:https://events.umich.edu/event/143694
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Basic Science,Research,biomedical research,Biology,Bioinformatics
LOCATION:Medical Science Unit I - 4B700
CONTACT:
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DTSTAMP:20260402T123116
DTSTART;TZID=America/Detroit:20260318T160000
DTEND;TZID=America/Detroit:20260318T170000
SUMMARY:Careers / Jobs:Michigan Democratic Party Coordinated Campaign Info Session on Campaign Opportunities
DESCRIPTION:The Michigan Democratic Party's Coordinated Campaign is looking to fill 100+ positions for the upcoming 2026 midterm elections!If you are interested in opportunities to work on a campaign for the Michigan Democratic Party\, please attend this information session where theirstaff will share more about upcoming job opportunities such as the field organizer role and campus fellows program.This event's information is shown in Handshake as well as on the Happening @ Michigan calendar so that it will be seen by a larger number of U-M Students. You can only register to attend this event within Handshake. If you'd like to indicate that you'll be attending this event and see more details\, please go to thiswebpage:  https://umich.joinhandshake.com/events/1908077/share_preview  We want to ensure full and equitable participation in our events. If an accessibility accommodation would promote your full participation in this event\, please indicate your accommodation requirements via the link below\, preferably at least 14 days prior to the program to ensure sufficient time for arranging your requestedaccommodation(s) or exploring suitable alternatives. If you have any questions regarding access to our programs\, please don't hesitate to reach out to Cierra Sutherland at cierrasu@umich.edu. Accessibility accommodation form: https://forms.gle/FmFn35ZLxJ8kvPfSA  #UCC
UID:145150-21896735@events.umich.edu
URL:https://events.umich.edu/event/145150
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:Student Activities Building, Maize and Blue Auditorium, 515 E Jefferson St, Ann Arbor, MI, United States
CONTACT:
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