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DTSTAMP:20231025T094006
DTSTART;TZID=America/Detroit:20231120T160000
DTEND;TZID=America/Detroit:20231120T170000
SUMMARY:Workshop / Seminar:ISRMT seminar: Geometry of half-space log-gamma polymers
DESCRIPTION:The half-space directed polymer is a variant of directed polymer that studies how polymers behave in the presence of an attractive wall. Depending on the strength of the boundary\, the polymers are expected to have two distinct phases: the bound phase and the unbound phase. In this talk\, I will focus on the half-space polymer model with log-gamma weights which makes the model integrable. I will describe our results in the unbound phase where we obtain KPZ exponents and in the bound phase where we obtain stochastic boundedness of the endpoint. Our proof proceeds by constructing the half-space log-gamma line ensemble which has a novel feature of attraction/repulsion at the boundaries. Based on two joint works: one with Guillaume Barraquand and Ivan Corwin\, and one with Weitao Zhu.
UID:114277-21832589@events.umich.edu
URL:https://events.umich.edu/event/114277
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Mathematics,seminar
LOCATION:East Hall - EH1866
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20231030T153200
DTSTART;TZID=America/Detroit:20231120T160000
DTEND;TZID=America/Detroit:20231120T170000
SUMMARY:Workshop / Seminar:RNA Innovation Seminar: George Lisi\, Brown University
DESCRIPTION:HYBRID SEMINAR:\nIn-person: BSRB\, ABC seminar rooms\nZoom: https://umich.zoom.us/webinar/register/WN_5NWlftG_TZGoYjig93GN4w\n\nAbstract: This talk will focus on long-range signaling in CRISPR-Cas9\, a cutting-edge genome editing tool. The transformative potential of Cas9 as a precision therapeutic cannot be realized without an understanding of its interdomain communication and the mitigation of deleterious off-target cleavage\, which is being characterized at the atomic level in the group. A series of vignettes will highlight NMR studies of Cas9 through a “divide-and-conquer” approach using engineered protein constructs and first demonstrate that multi-timescale motions in the catalytic nuclease of Cas9 propagates chemical information that regulates cleavage of double-stranded DNA. The talk will also highlight specificity-enhancing mutations in Cas9 that rewire its regulatory mechanism and RNA interactions at the molecular level to mitigate off-target DNA cleavage. Critical energetics of the mechanism will be discussed\, including the importance of metal ions and the protonation state of the catalytic histidine\, studied via catalytic pocket mutations that limit conformational sampling of the Cas9 active state. Lastly\, insight from canonical Cas9s will be expanded to highly stable thermophiles that are more promising for genome engineering and offer tunable high-temperature DNA editing and RNA binding. The underlying chemistry and atomic level dynamics of Cas9 will be linked to its nucleic acid interactions and biological outcomes\, hopefully opening new avenues for intuitive manipulation of its function and precision therapeutic properties.
UID:109680-21822696@events.umich.edu
URL:https://events.umich.edu/event/109680
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biosciences
LOCATION:Taubman Biomedical Science Research Building - ABC Seminar Room
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20231205T123136
DTSTART;TZID=America/Detroit:20231120T160000
DTEND;TZID=America/Detroit:20231120T170000
SUMMARY:Careers / Jobs:Scotiabank Information Session- Spotlight on Corporate Functions
DESCRIPTION:Scotiabank's Corporate Functions Internships for the Summer of2024 are officially live!\n\n💼 Are you looking to gain experience in agrowing bank over the summer of 2024?\n📊 Do you have an analytical skillset and passion for solving problems?\n🔅 Are you a great team player and enjoy working in a collaborative work environment?\n📚 Are you interested in a way to pursue finance outside of banking roles? \n\nIf you answered “yes” to some or all of these questions\, join our Information Session to learn about teams like Audit\, Compliance\, Treasury\, RegulatoryRelations and more to prepare for our interview processes!
UID:115414-21834645@events.umich.edu
URL:https://events.umich.edu/event/115414
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:
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