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DTSTAMP:20250306T114528
DTSTART;TZID=America/Detroit:20250404T120000
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SUMMARY:Workshop / Seminar:Population dynamics and universal statistics of tumor-inhabiting bacteria
DESCRIPTION:Environments such as the ocean\, the soil\, and the human body support tremendous microbial diversity. Uncovering the mechanisms by which a large number of microbial species can coexist on limited resources remains an important open problem. Here I will discuss this problem in unique context: bacteria that inhabit tumors. Bacterial colonization of solid tumors is widespread\, but how the tumor environment affects bacterial growth (and vice versa) is poorly understood. Our experimental collaborators infect mouse tumors with DNA-barcoded bacteria\, creating competition among thousands of clonal bacterial \"species\". We find that after an initial expansion period\, clone sizes exhibit universal power-law statistics. These statistics are robust across experiments and collection times\, and unique to bacteria grown in the tumor environment rather than in liquid culture. Combining population ecology with nonequilibrium statistical physics\, we develop a mechanistic theory of intra-tumor bacterial growth that includes an infection bottleneck\, local growth constraints\, global resource competition\, and environmental noise. Our simple physical theory captures the dynamics and the statistics of the experiments\, explains the uniqueness of the observations to the tumor environment\, and represents an important step in quantitatively characterizing the tumor microbiome.
UID:125336-21854756@events.umich.edu
URL:https://events.umich.edu/event/125336
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biophysics
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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DTSTAMP:20250806T162329
DTSTART;TZID=America/Detroit:20250404T120000
DTEND;TZID=America/Detroit:20250404T124500
SUMMARY:Film Screening:Sea Monsters
DESCRIPTION:The film follows a curious and adventurous Dolichorhynchops – familiarly known as a ‘dolly’ – as she travels through the most dangerous oceans in history. Along the way\, she encounters long-necked plesiosaurs\, giant turtles\, enormous fish\, fierce sharks\, and the most dangerous sea monster of all– the mosasaur.
UID:121866-21875796@events.umich.edu
URL:https://events.umich.edu/event/121866
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Museum,museums,natural history museum
LOCATION:Museum of Natural History
CONTACT:
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DTSTAMP:20250205T181816
DTSTART;TZID=America/Detroit:20250404T120000
DTEND;TZID=America/Detroit:20250404T123000
SUMMARY:Performance:Vinson Lam\, carillon
DESCRIPTION:Vinson Lam performs on the Charles Baird Carillon\, an instrument of 53 bronze bells located inside the Burton Memorial Tower. The largest bell\, which strikes the hour\, weighs 12 tons\, while the smallest bell\, 4½ octaves above\, weighs just 15 pounds.\n\nThirty-minute recitals are performed on the Charles Baird Carillon at noon every weekday that classes are in session\, followed by visitor Q&A with the carillonist. The bell chamber may be accessed via a combination of elevator and stairs. Take the elevator to the highest floor possible (floor 8)\, and then climb two flights of stairs (39 steps) to the bell chamber (floor 10). Hearing protection earmuffs are provided for visitors. Be prepared to walk on ice and snow in the bell chamber during winter. Built in 1936\, the Charles Baird Carillon is not ADA accessible. Visitors with mobility concerns are invited to visit the Lurie Carillon.
UID:132400-21870884@events.umich.edu
URL:https://events.umich.edu/event/132400
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Free,Music,Talk
LOCATION:Burton Memorial Tower
CONTACT:
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