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DTSTART:20070311T020000
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DTSTAMP:20231212T142022
DTSTART;TZID=America/Detroit:20231212T150000
DTEND;TZID=America/Detroit:20231212T170000
SUMMARY:Workshop / Seminar:Study Paws with Sociology
DESCRIPTION:Take a study break (aka \"paws\") to pet the dogs from Therapaws of Michigan! There will be food\, arts & crafts\, and some free goodies for grabs. This event is open to LSA undergraduate students. \n
UID:115568-21835025@events.umich.edu
URL:https://events.umich.edu/event/115568
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20231208T133927
DTSTART;TZID=America/Detroit:20231212T160000
DTEND;TZID=America/Detroit:20231212T180000
SUMMARY:Social / Informal Gathering:INFORMS board game night
DESCRIPTION:INFORMS @ U-M is planning to host an End of Year Board Game Social on Tuesday\, December 12th from 4-6 pm in IOE 2717. We will be providing food\, drinks\, and board games. You are also welcome to bring your own board games. If you are interested in attending\, please fill out the RSVP form so we can plan how much food we should order.
UID:115950-21835877@events.umich.edu
URL:https://events.umich.edu/event/115950
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Industrial And Operations Engineering
LOCATION:Industrial and Operations Engineering Building - 2717
CONTACT:
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DTSTAMP:20231114T150051
DTSTART;TZID=America/Detroit:20231212T160000
DTEND;TZID=America/Detroit:20231212T171500
SUMMARY:Workshop / Seminar:Molecular consequences of deregulated rRNA processing and modification in biology and disease
DESCRIPTION:Ribosome biogenesis in eukaryotes is a complex and highly regulated process involving the action of over 200 assembly factors\, bringing together a total of 79 proteins and 4 ribosomal RNAs in yeast. The maturation of rRNAs from precursor transcripts is a critical aspect of ribosome biogenesis involving the precise processing steps facilitated by essential nucleases\, among which the RNA exosome complex plays a pivotal role. Additionally\, over a hundred RNA chemical modifications\, the majority of which are guided by small nucleolar RNAs\, are deposited on the rRNAs co- and post-transcriptionally. Despite tight regulatory steps\, rRNA processing and modifications go awry in several human diseases. Missense mutations in genes encoding structural subunits of the RNA exosome cause a growing family of diseases with diverse pathologies\, collectively termed RNA exosomopathies. Similarly\, pathogenic mutations that impact rRNA modifications are associated with neurodevelopmental disorders and implicated in the onset and progression of cancer. I will highlight our recent findings that shed light on the molecular consequences of dysregulated rRNA processing and rRNA modifications. These molecular defects have a profound impact on both the quantity and quality of ribosomes within the translating pool\, thereby disrupting cellular protein homeostasis. Our results underscore the intricate interplay between ribosome biogenesis\, RNA processing\, modifications\, and disease pathogenesis\, providing new insights and a deeper understanding of these complex cellular processes.
UID:109270-21821331@events.umich.edu
URL:https://events.umich.edu/event/109270
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Chemical Biology,Chemistry,Science
LOCATION:Chemistry Dow Lab - 1200
CONTACT:
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