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DTSTART:20070311T020000
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DTSTAMP:20231120T134314
DTSTART;TZID=America/Detroit:20231201T120000
DTEND;TZID=America/Detroit:20231201T130000
SUMMARY:Workshop / Seminar:Metal Homeostasis at the host – pathogen interface: from nutritional immunity to nutritional intoxication
DESCRIPTION:Antibiotic resistance is a global health concern that causes over one million deaths worldwide. Understanding molecular mechanisms of bacterial pathogenesis and the innate immune response is critical for identifying new antimicrobial therapeutic approaches. My lab is interested in characterizing the underlying determinants of metal homeostasis with an eye toward creating new antimicrobial agents. One-third of the proteome is predicted to comprise metalloproteins. Metals are essential for all forms of life as they serve as enzymatic cofactors\, structural stabilizers and chemical messengers. However\, high concentrations of metals are toxic. Thus\, maintenance of metal homeostasis is essential at the host-pathogen interface. For example\, S100A12 is a high affinity transition metal binding protein that starves invading pathogens and prevents them from acquiring essential zinc\, in a process termed nutritional immunity. I will present recent results from my lab that sugges t zinc binding to S100A12 potentiates oligomerization and is associated with activation of inflammation through the receptor for advanced glycation end products. The importance of zinc regulation is also highlighted in the pathogenesis of the human pathogen Streptococcus agalactiae\, one of the primary causes of adverse pregnancy outcomes. CadD\, a metal efflux transporter is essential for S. agalactiae to resist zinc intoxication by macrophages\, thereby facilitating ascending infection in a pregnant host. Together\, these data demonstrate the importance of understanding metal homeostasis and provide potential pathways to overcoming antibiotic resistance.
UID:109096-21821065@events.umich.edu
URL:https://events.umich.edu/event/109096
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:seminar,Biophysics
LOCATION:Chemistry Dow Lab - 1400
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20231121T143253
DTSTART;TZID=America/Detroit:20231201T120000
DTEND;TZID=America/Detroit:20231201T130000
SUMMARY:Presentation:Neuroscience Graduate Program Dissertation Defense
DESCRIPTION:Presenting\, “Soma-to-germline transition in a chromatin-linked neurodevelopmental disorder”\nDr. Shigecki Iwase\, Chair
UID:115444-21834684@events.umich.edu
URL:https://events.umich.edu/event/115444
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Graduate and Professional Students,In Person,Neuroscience
LOCATION:Palmer Commons - Forum Hall
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20231128T143210
DTSTART;TZID=America/Detroit:20231201T120000
DTEND;TZID=America/Detroit:20231201T130000
SUMMARY:Workshop / Seminar:NHATS/NSOC Webinar Series
DESCRIPTION:Speaker: Kate Duchowny\, Research Assistant Professor\, Survey Research Center\, Institute for Social Research\n\nAll webinars are held Friday 12-1 p.m. ET.\n\nRegister for the 2023-2024 NHATS/NSOC Webinar Schedule\nhttps://micda.isr.umich.edu/2023-2024-nhats-nsoc-webinar-series/
UID:115586-21835050@events.umich.edu
URL:https://events.umich.edu/event/115586
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Environment,Aging
LOCATION:Off Campus Location
CONTACT:
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