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DTSTAMP:20250326T093027
DTSTART;TZID=America/Detroit:20250408T160000
SUMMARY:Workshop / Seminar:The Radical Lives of Anaerobes and How to Fight Them
DESCRIPTION:Pathogenic bacteria that infect the gastrointestinal and respiratory tract form biofilms that are largely anaerobic\, modulating their metabolic lifestyle and virulence. Many of these microbes utilize acetate fermentation via the enzyme pyruvate formate lyase (PFL)\, which catalyzes the production of acetyl-CoA and formate from pyruvate via a radical mechanism\, enabling additional ATP production and the de novo synthesis of proteins and nucleic acids. We have investigated the mechanism of PFL via mechanism-based inhibitors to reveal the essential role of two cysteine thiyl radicals in catalysis and estimate their reactivity for the first time. Additionally\, we have demonstrated the role of nitric oxide (NO) as an irreversible inhibitor of they glycyl radical enzyme PFL as well as glycyl radical enzymes as a class and their radical S-adenosylmethionine-dependent activases via the production of dinitrosyl iron complexes. These results set the stage for the development of mechanism-based inhibitors of PFL and other glycyl radical enzymes and provide a biochemically informed approach to narrow-spectrum site-specific antibiotic development for the treatment of gastrointestinal and pulmonary disease.
UID:125093-21854406@events.umich.edu
URL:https://events.umich.edu/event/125093
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Chemical Biology,Chemistry
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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DTSTAMP:20250401T114502
DTSTART;TZID=America/Detroit:20250408T160000
DTEND;TZID=America/Detroit:20250408T173000
SUMMARY:Lecture / Discussion:Why Gender History Needs Women’s History (and vice-versa)
DESCRIPTION:Margaret Chowning is the Muriel McKevitt Sonne Chair Professor of Latin American History (emerita) at the University of California\, Berkeley. She is the author of Wealth and Power in Provincial Mexico from the Late Colony to the Revolution (Stanford\, 1999)\, Rebellious Nuns: The Troubled History of a Mexican Convent (Oxford\, 2006)\, and Catholic Women and Mexican Politics\, 1750-1940 (Princeton\, 2023). She is working on a book of urban history in Mexico\, with special attention to the impact that liberal policies and liberal “values” exerted on gender relations and urban life in the nineteenth century.\n\nHer presentation\, “Why Gender History Needs Women’s History (and vice-versa)\,” is drawn from her experience conceptualizing\, researching\, and organizing her recent book\, Catholic Women and Mexican Politics.
UID:134551-21874506@events.umich.edu
URL:https://events.umich.edu/event/134551
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:History,Humanities,Latin America,Women's Studies
LOCATION:Tisch Hall - 1014
CONTACT:
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DTSTAMP:20250408T142035
DTSTART;TZID=America/Detroit:20250408T160000
DTEND;TZID=America/Detroit:20250408T190000
SUMMARY:Workshop / Seminar:Winter 2025 - Diversity and Inclusion Department Design Showcases
DESCRIPTION:The Michigan Housing Diversity and Inclusion Department is looking forward to starting the design process for three new multicultural spaces which will be part of the Central Campus Residential Development\, scheduled to open in Fall of 2026:Building One - Grace Lee Boggs Multicultural Lounge\nBuilding Three - Mino-Bimaadiziwin Multicultural Lounge\nBuilding Five - Origins Multicultural Engagement Space\nThe focus of the design showcases will be to gather feedback related to the functional components of the lounge\, such as the furniture and color schemes for each lounge. The design showcase opportunities are drop-in style\, so please join us at any point of time you are able.
UID:133548-21873231@events.umich.edu
URL:https://events.umich.edu/event/133548
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Ambatana - The Afro American Multicultural Lounge, South Quad, 600 East Madison Street, Ann Arbor, MI
CONTACT:
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