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DTSTART:20070311T020000
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DTSTAMP:20250806T162329
DTSTART;TZID=America/Detroit:20250228T120000
DTEND;TZID=America/Detroit:20250228T123000
SUMMARY:Film Screening:Sea Monsters
DESCRIPTION:The film follows a curious and adventurous Dolichorhynchops – familiarly known as a ‘dolly’ – as she travels through the most dangerous oceans in history. Along the way\, she encounters long-necked plesiosaurs\, giant turtles\, enormous fish\, fierce sharks\, and the most dangerous sea monster of all– the mosasaur.
UID:121866-21866323@events.umich.edu
URL:https://events.umich.edu/event/121866
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Museum,museums,natural history museum
LOCATION:Museum of Natural History - Planetarium & Dome Theater
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250305T120030
DTSTART;TZID=America/Detroit:20250228T120000
DTEND;TZID=America/Detroit:20250228T235959
SUMMARY:Other:Spring Break
DESCRIPTION:Lets go rowing
UID:132653-21871504@events.umich.edu
URL:https://events.umich.edu/event/132653
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:Gainesville, GA
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250224T113813
DTSTART;TZID=America/Detroit:20250228T120000
DTEND;TZID=America/Detroit:20250228T130000
SUMMARY:Workshop / Seminar:Visualizing structural dynamics in the 7SK RNA\, a major regulator of transcription elongation
DESCRIPTION:Structural plasticity is integral to RNA function\; however\, there are currently few methods to quantitatively resolve RNAs that have multiple structural states. Here\, we integrate solution NMR spectroscopy and chemical probing approaches to visualize a two-state conformational ensemble for the central stem-loop 3 (SL3) of 7SK RNA\, a critical element for 7SK RNA function in transcription regulation. We find that the SL3 distal end undergoes slow exchange between two equally populated yet structurally distinct states in both isolated SL3 constructs and full-length 7SK RNA. We rationally designed constructs that lock SL3 into a single state and demonstrate that both NMR and chemical probing data fit to a linear combination of the two states. A survey of vertebrate 7SK RNA sequences shows exquisite sequence dependence on the two-state equilibrium. Moreover\, we find that changing environmental variables such as temperature and ionic strength shifts the equilibrium between the two states. We determine thermodynamic parameters such as divalent cation binding affinities for individual states and find that the two states have strikingly different responses to addition of divalent cations. Together\, these data indicate that the two states significantly differ in their structural and dynamic properties\, which may impact SL3 function in transcription regulation. These results provide new insights into 7SK RNA structural dynamics and demonstrate the utility of integrating chemical probing with NMR spectroscopy to gain quantitative insights into RNA conformational ensembles.
UID:125334-21854754@events.umich.edu
URL:https://events.umich.edu/event/125334
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biophysics
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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