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DTSTAMP:20240314T152302
DTSTART;TZID=America/Detroit:20240412T120000
DTEND;TZID=America/Detroit:20240412T130000
SUMMARY:Workshop / Seminar:Structural mechanisms of DNA priming by polymerase α–primase
DESCRIPTION:The mechanism by which polymerase α–primase (polα–primase) synthesizes chimeric RNA-DNA primers of defined length and composition\, necessary for replication fidelity and genome stability\, is unknown. Here\, we report cryo-EM structures of polα–primase in complex with primed templates representing various stages of DNA synthesis. Our data show how interaction of the primase regulatory subunit with the primer 5′-end facilitates handoff of the primer to polα and increases polα processivity\, thereby regulating both RNA and DNA composition. The structures detail how flexibility within the heterotetramer enables synthesis across two active sites and provide evidence that termination of DNA synthesis is facilitated by reduction of polα and primase affinities for the varied conformations along the chimeric primer/template duplex. Together\, these findings elucidate a critical catalytic step in replication initiation and provide a comprehensive model for primer synthesis by polα–primase.
UID:109108-21821076@events.umich.edu
URL:https://events.umich.edu/event/109108
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biophysics,seminar
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20231214T123048
DTSTART;TZID=America/Detroit:20240412T120000
DTEND;TZID=America/Detroit:20240412T160000
SUMMARY:Exhibition:The Art of Resistance in Early America
DESCRIPTION:The exhibition addresses the theme of the LSA Fall 2023 semester at the University of Michigan: \"Arts & Resistance.\" This exhibit asks us to think about resistance in different settings\, and in different forms. What \"arts\" did Americans in the eighteenth and nineteenth centuries use to resist various forms of power? The exhibit aims to show how the people of our nation's past tried to answer those questions\n\nExhibit Hours: Monday - Friday - Noon - 4 pm\n\nLink to online exhibit:https://clements.umich.edu/exhibit/the-art-of-resistance/
UID:115674-21835360@events.umich.edu
URL:https://events.umich.edu/event/115674
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:american culture,american history,Free,history,In Person,libraries,Library,Tour,Undergraduate,Undergraduate Students
LOCATION:William Clements Library
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20240427T063119
DTSTART;TZID=America/Detroit:20240412T120000
DTEND;TZID=America/Detroit:20240412T130000
SUMMARY:Careers / Jobs:UC Health Pharmacy Virtual Meet and Greet: Pharmacists and Residency Grads
DESCRIPTION:Pharmacists\, Graduating Pharmacy Students and Graduating Pharmacy Residents\, join our UC Health Pharmacy leadership team for a virtualmeet and greet to discuss our clinical pharmacist and specialist opportunities and related practice areas. This is an opportunity to learn about the work our practice settings and opportunities as an integral member of our Retail\, Inpatient\, Infusion and Specialty patient care teams.\n\nOur Human Resources team will also be on hand\, discussing and answering questions about our benefits\, our health system\, and the Cincinnati area. \n\nThis event is open to both new pharmacy residency graduates\, as well as experienced pharmacists and those interested in relocating to the Cincinnati area. \n
UID:120156-21844164@events.umich.edu
URL:https://events.umich.edu/event/120156
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:
CONTACT:
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