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DTSTART:20070311T020000
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DTSTAMP:20240404T095257
DTSTART;TZID=America/Detroit:20240412T160000
DTEND;TZID=America/Detroit:20240412T171500
SUMMARY:Workshop / Seminar:New tools for flow-based peptide and protein synthesis
DESCRIPTION:The protein MYC is an intrinsically disordered transcription factor that is upregulated in>50% of cancers and engages in numerous protein-protein interactions. [1] These interactions\nare often regulated through posttranslational modifications (PTMs) within MYC’s N-terminus\n(transactivation domain)\, most commonly (poly)phosphorylation. Studying these interactions\non a molecular level requires proteins with unique and defined PTM patterns\, which are\nchallenging to obtain by recombinant methods. [2] Flow-based solid-phase peptide synthesis\n(SPPS) could therefore be used to obtain long\, uniquely modified MYC peptides to study\nPTM-dependent binding interactions on a molecular level. [3\,4]\nA challenge that arose during the chemical synthesis of MYC’s transactivation domain—that\nis often encountered in SPPS—was the aggregation of growing peptide chains (\"difficult\nsequences”)\, which can lead to incomplete couplings. Previous research into this sequence-\ndependent phenomenon was limited by the lack of high-throughput analytical methods\,\nthus impeding systematic analysis. While flow-based SPPS allows for aggregation detection\,\nit has so far not led to the development of tools for its suppression.\nTo enable the synthesis of MYC’s transactivation domain\, we developed a “Synthesis Tag”\n(SynTag) consisting of six arginines connected via a cleavable MeDbz linker. [5] SynTag\neffectively improves batch- and flow-SPPS of “difficult sequences”\, enhances the solubility of\nthe cleaved peptides and provides direct access to native sequences by hydrolysis\, or\npeptide thioesters for Native Chemical Ligation (NCL). We demonstrate its utility in the first\nchemical synthesis of the MYC transactivation domain with a single NCL. We envisage\nSynTag to become a broadly applicable tool that enables the synthesis and study of\npreviously unattainable peptides and proteins.\n\n[1] C. Lourenco\, D. Resetca\, C. Redel\, P. Lin\, A. S. MacDonald\, R. Ciaccio\, T. M. G. Kenney\, Y. Wei\,\nD. W. Andrews\, M. Sunnerhagen\, C. H. Arrowsmith\, B. Raught\, L. Z. Penn\, Nat. Rev. Cancer\n2021\, 21\, 579–591\n[2] A. C. Conibear\, Nat. Rev. Chem. 2020\, 4\, 674–695\; T. Bilbrough\, E. Piemontese\, O. Seitz\, Chem.\nSoc. Rev. 2022\, 51\, 5691–5730\n[3] N. Hartrampf\, A. Saebi\, M. Poskus\, Z. P. Gates\, A. J. Callahan\, A. E. Cowfer\, S. Hanna\, S.\nAntilla\, C. K. Schissel\, A. J. Quartararo\, X. Ye\, A. J. Mijalis\, M. D. Simon\, A. Loas\, S. Liu\, C.\nJessen\, T. E. Nielsen\, B. L. Pentelute\, Science 2020\, 368\, 980.\n[3] E. T. Williams\, K. Schiefelbein\, M. Schuster\, I. M. M. Ahmed\, M. De Vries\, R. Beveridge\, O.\nZerbe\, N. Hartrampf\, ChemRxiv 2024\, DOI: 10.26434/chemrxiv-2024-mfpkx.\n[4] H. Bürgisser\, E. T. Williams\, R. Lescure\, A. Premanand\, A. Jeandin\, N. Hartrampf\, ChemRxiv\n2023\, DOI: 10.26434/chemrxiv-2023-7mz2c.
UID:120687-21845136@events.umich.edu
URL:https://events.umich.edu/event/120687
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Chemistry
LOCATION:Chemistry Dow Lab - 1706
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20240202T164100
DTSTART;TZID=America/Detroit:20240412T160000
DTEND;TZID=America/Detroit:20240412T173000
SUMMARY:Workshop / Seminar:Preprint Algebraic Geometry Seminar: Du Bois complex and extension of forms after Park
DESCRIPTION:TBA
UID:118322-21840884@events.umich.edu
URL:https://events.umich.edu/event/118322
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Mathematics
LOCATION:East Hall - 4096
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20240119T143313
DTSTART;TZID=America/Detroit:20240412T163000
DTEND;TZID=America/Detroit:20240412T173000
SUMMARY:Well-being:SAPAC BIPOC Peer Led Support Group Winter 2024
DESCRIPTION:BIPOC PLSG (peer led support group)\, is a drop-in\, confidential healing space for survivors of sexual assault\, intimate partner violence\, stalking\, and/or sexual harassment\, who identify as people of color. Facilitated by student staff\, BIPOC PLSG is a place for survivors of color at UM to find not only community but healing opportunities\, including anxiety-reduction\, self-care activities\, and mindfulness.\n\nPOC PLSG offers low-key activities as well as a safe space for sharing experiences with racial/ethnic identity\, violence\, and the intersection between both\, as people are comfortable sharing. Survivors are welcome whether they experienced harm in college\, or earlier in life.\n\nThis space specifically centers UM student survivors who identify as people of color\; if you do not identify as a person of color\, we encourage you to consider joining SAPAC’s general Peer Led Support Group: sapac.umich.edu/PLSG\n\n \n\nTo fill out a confidential interest form and receive emails from facilitators: BIPOC PLSG Interest Form: forms.gle/uW7Nq6FfhoiwvtuL9\n\nEmail: bipoc-plsg@umich.edu\n\n \n\nWinter 2024 Meeting Schedule:\n\nWhen: \n\nMondays via Zoom - 5:30-6:30pm (first meeting on Monday Jan 22nd)\nFridays in person - 4:30-5:30pm (first meeting on Friday Jan 19th) \n\nLocation: \n\nIn person - SAPAC Office\, 4100 Michigan Union\, Virtual - Zoom
UID:117510-21839419@events.umich.edu
URL:https://events.umich.edu/event/117510
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:free,Health & Wellness,peer education,sapac,Well-being
LOCATION:Michigan Union - 4100 (SAPAC Shared Space)
CONTACT:
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