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DTSTAMP:20261021T141949
DTSTART;TZID=America/Detroit:20261103T110000
DTEND;TZID=America/Detroit:20261103T120000
SUMMARY:Workshop / Seminar:MCDB Dissertation Defense Seminar> The Regulation and Interactome of an H4K20-Specific Demethylase in Dosage Compensation of C. elegans
DESCRIPTION:In species that use sex chromosomes to differentiate between its sexes\, there is a difference in sex chromosome number and the number of gene copies which results in unequal gene dosage. In species that cannot tolerate this imbalance in gene dosage\, the dosage compensation process is applied in which the gene expression levels between the two sexes are made equal. In mammals\, female somatic cells (XX) have one X chromosome inactivated to equalize to the single X chromosome in male somatic cells (XY). In C. elegans\, hermaphrodites (XX) downregulate both X chromosomes by half to equalize to the single X chromosome in their male counterparts (XO). \n\nDosage compensation in C. elegans is conducted primarily by the Dosage Compensation Complex (DCC)\, a multimeric set of proteins including a CondensinIDC complex and several additional proteins that bind\, compact and downregulate the X chromosomes in hermaphrodites. One of the non-condensin proteins in the DCC is DPY-21\, a Histone 4 Lysine 20 (H4K20)- specific demethylase. DPY-21 binds to the hermaphroditic X chromosomes and converts H4K20 di-methylation (H4K20me2) into mono-methylation (H4K20me1). This results in the enrichment of the repressive H4K20me1 mark on the X and the transcriptional downregulation of the X chromosomes. Although DPY-21 is part of the DCC\, it localizes to the X chromosomes at a later stage of embryogenesis and does not bind mitotic chromosomes\, contrasting to the other DCC components. Additionally\, DPY-21 has been shown to have a DCC-independent role in the germline where dosage compensation in unrequired. This drives the question of the regulation of DPY-21 and its interactors in addition to the DCC. \n\nThe first part of my thesis is the characterization of DPY-21 regulation through phosphorylation. Using CRISPR/Cas9 site-directed mutagenesis\, I generated a dpy-21 phosphomutant C.elegans strain by mutating the phosphosites of DPY-21 into Alanines to render them non-phosphorylatable. Through physiological assays\, I found that the dpy-21 phosphomutant C. elegans strain has defects in embryogenesis and larval stages. In embryogenesis\, the phosphomutations disrupts DPY-21’s localization to the X chromosomes and delays the enrichment of H4K20me1 to the X chromosomes. Through biochemical and imaging analysis\, I demonstrate that the global levels of 4K20me1 is increased in the phosphomutant strain\, suggesting that the mutant protein may be hyperactive. At the larval stages\, the dpy-21 phosphomutant strain exhibits developmental delay and increased propensity to form dauers. These defects are resolved by  adulthood which implies that DPY-21’s activity is most critical in the embryonic and larval stages.\n\nThe second part of my work revealed novel interactors  of DPY-21. I conducted an immunoprecipitation-mass spectrometry (IP-MS  ) on DPY-21 to establish its interacting partners and found the kinase SPK-1 to be a top interactor of DPY-21. In spk-1 mutants\, there is delayed H4K20me1 enrichment on the X chromosomes in embryogenesis which ultimately results in disrupted H4K20me1 enrichment on the X chromosomes in adults. This shows that SPK-1 may regulate DPY-21 although this may be indirect. Taken together\, my work has characterized a novel dpy-21 mutant for the field that leads to its hyperactivity in generating H4K20me1 globally as well as the novel interactor SPK-1 that may regulate DPY-21.
UID:153927-21916755@events.umich.edu
URL:https://events.umich.edu/event/153927
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Thesis Defense,Graduate Students,Bsbsigns,Biology
LOCATION:Biological Sciences Building - 1010
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261102T072055
DTSTART;TZID=America/Detroit:20261103T113000
DTEND;TZID=America/Detroit:20261103T123000
SUMMARY:Workshop / Seminar:Laser Training
DESCRIPTION:You must complete FABLab Safety Training and have watched the Laser cutter training video before attending this session!
UID:152896-21917608@events.umich.edu
URL:https://events.umich.edu/event/152896
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Taubman College Laser Cutter Room
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261027T113646
DTSTART;TZID=America/Detroit:20261103T113000
DTEND;TZID=America/Detroit:20261103T125000
SUMMARY:Workshop / Seminar:The Allocative Cost of War: A View to a Kill. . .ing of Productivity
DESCRIPTION:Why is war so economically costly? Our answer is that modern war lowers output not only by destroying productive factors\, but also by making the surviving economy work less efficiently. Using uniquely comprehensive firm-level data collected during Russia’s full-scale invasion of Ukraine in 2022\, we document a dramatic collapse in allocative productivity in Ukraine. To sharpen identification and explore key mechanisms (including the role of war intensity\, internal displacement\, reallocation\, and macroeconomic instability)\, we exploit spatial heterogeneity across Ukrainian districts and comparisons with Russian aggression in 2014 and the 2008 Global Financial Crisis. Our key policy implication is that restoring allocative efficiency–and preparing institutional arrangements that facilitate rapid reallocation in times of stress–is critical for sustaining economic capacity\, defense\, and national security.
UID:149568-21906713@events.umich.edu
URL:https://events.umich.edu/event/149568
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Macroeconomics,seminar,Economics
LOCATION:North Quad - 4325
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20260911T131259
DTSTART;TZID=America/Detroit:20261103T120000
DTEND;TZID=America/Detroit:20261103T160000
SUMMARY:Exhibition:“Who Counts? A History of Voting in America”
DESCRIPTION:Changes over the course of the nineteenth century in how Americans voted\, from voice vote to public ballot box to private voting booth\, also saw changes in the material culture that surrounded voting. Ballots and ballot boxes\, campaign pins and ribbons\, blank lists and pre-printed party tickets\, lanterns and banners–the creative forces of the American print industry filled the country’s cities and small towns with the ephemera of electioneering.\n\nAs you look at the items in this exhibit\, think about what they tell us about how Americans in the past felt about voting\, and about how voting felt. How did Election Days feel when they were full of parades and music and public drinking? What was it like to vote when everyone around you knew who you voted for? And\, most of all\, who counted as a voter\, and who did the counting?\n\nOn view September 11-December 22\, weekdays from 12-4 pm.
UID:152024-21912682@events.umich.edu
URL:https://events.umich.edu/event/152024
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Event,Exhibit,Exhibition,history,In Person,libraries,Library,Tour,William L Clements,Americana,american history,american culture
LOCATION:William Clements Library
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261102T072059
DTSTART;TZID=America/Detroit:20261103T120000
DTEND;TZID=America/Detroit:20261103T140000
SUMMARY:Workshop / Seminar:2026-2027 CommuniTEA
DESCRIPTION:Weekly gathering for students\, staff\, and faculty to build community with the Trotter/MESA team and discuss the week’s events. Organizations and units are encouraged to collaborate and offer light refreshments or share tea practices that center their cultural practices. Come join us for good conversation\, food and fun!
UID:151558-21911745@events.umich.edu
URL:https://events.umich.edu/event/151558
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Trotter Multicultural Center - Sankofa Lounge
CONTACT:
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