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DTSTART:20070311T020000
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DTSTAMP:20260928T140340
DTSTART;TZID=America/Detroit:20261020T160000
DTEND;TZID=America/Detroit:20261020T171500
SUMMARY:Workshop / Seminar:Mechanistic Insights into Metal-Protein Interactions: Implications for Neurodegenerative Disease Progression and Intervention
DESCRIPTION:Elevated levels of protein expression and aberrant metal exposure have been reported in many neurodegenerative diseases\, including Huntington’s Disease (HD). While there is currently no cure for HD\, metal chelation therapies have been shown to assuage disease symptoms including chorea. These observations underscore the critical need to understand how metal-protein interactions are involved in disease pathogenesis. Our objective in this work is to elucidate the role of copper (Cu) and other biorelevant metals in HD and\, more specifically\, their interactions with the huntingtin protein (htt). We aimed to characterize the Cu-htt interaction and speciation trends in our in vitro HD system\, as well as the influence of disease-relevant Cu concentrations on protein oligomerization/aggregation both in vitro and in vivo. We utilized multiple spectroscopic techniques (circular dichroism\, electron paramagnetic resonance\, UV-Vis absorption\, dynamic light scattering\, and mass spectrometry) that cover a broad range of energy scales\, allowing us to characterize protein structure at the molecular\, secondary structure\, and quaternary structure levels. Additionally\, site-directed mutagenesis of several putative metal binding residues was used to define the roles of specific amino acids in mediating oligomerization/aggregation\, metal binding\, and redox chemistry. Taken together\, our work has led to the first report of multiple copper binding sites in non-pathological htt and provides insight into one pathway for depletion of native htt pools that may contribute to HD.
UID:151930-21912476@events.umich.edu
URL:https://events.umich.edu/event/151930
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Chemistry,Inorganic Chemistry
LOCATION:Chemistry Dow Lab - CHEM 1640
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261016T222117
DTSTART;TZID=America/Detroit:20261020T170000
DTEND;TZID=America/Detroit:20261020T190000
SUMMARY:Conference / Symposium:Maize & Blue Cupboard Volunteering
DESCRIPTION:Come help us during normal operating hours\; as well as\, unload our weekly Food Gatherers deliveries and stock our shelves! If you are outside the U-M community\, please reach out to maize.blue.cupboard@umich.edu to sign up.
UID:102102-21914746@events.umich.edu
URL:https://events.umich.edu/event/102102
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Maize and Blue Cupboard inside Betsy Barbour
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261016T222115
DTSTART;TZID=America/Detroit:20261020T170000
DTEND;TZID=America/Detroit:20261020T180000
SUMMARY:Conference / Symposium:Markley (2026-2027) (Housing)
DESCRIPTION:
UID:150757-21914951@events.umich.edu
URL:https://events.umich.edu/event/150757
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Markley Concourse
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20261016T222120
DTSTART;TZID=America/Detroit:20261020T170000
DTEND;TZID=America/Detroit:20261020T190000
SUMMARY:Workshop / Seminar:U-M Global StorySLAM!
DESCRIPTION:Join us for a special evening as members of the U-M community share personal stories of living\, learning\, and growing in new places—whether that’s studying abroad or navigating life as an international student in the U.S. Hear candid accounts of funny\, moving\, eye-opening\, and transformative moments that shape our global journeys\, both near and far. Celebrate cultural insights\, new perspectives\, and the power of storytelling with our international community.Light refreshments provided. All are welcome!\nThis event is organized by the Center for Global & Intercultural Study\, Global Engagement — Office of the Provost\, the International Institute\, International Programs in Engineering\, Ross Global Initiatives\, and the International Center.
UID:150961-21910632@events.umich.edu
URL:https://events.umich.edu/event/150961
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:North Quad, Space 2435
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261006T113424
DTSTART;TZID=America/Detroit:20261020T180000
DTEND;TZID=America/Detroit:20261020T193000
SUMMARY:Workshop / Seminar:UMS 101: All About the Piano
DESCRIPTION:Ever wondered what goes on inside a concert grand piano before a master pianist takes the stage? Or how a master tuner coaxes the perfect sound out of thousands of moving parts?\n\nJoin us for All About the Piano\, a fun\, casual\, 90-minute workshop that takes you behind the scenes of one of the world’s most versatile instruments. Whether you are a lifelong classical music fan or just curious about how it all works\, this session will deepen your appreciation for your next UMS performance. This workshop will feature a professional piano tuner and a concert pianist as panelists. Together\, they will guide us through:\n\nThe Mechanics\nHow a piano actually works from the inside out.\n\nThe Art of Tuning\nThe meticulous process of tuning and choosing the perfect instrument for a live performance.\n\nLive Demonstrations\nReal-time examples and participatory activities that bring the music and mechanics to life.\n\nCome with your curiosity and your questions — and leave with a whole new perspective on every note you hear!
UID:153346-21915678@events.umich.edu
URL:https://events.umich.edu/event/153346
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Michigan Arts Festival,Music,Piano,UMS
LOCATION:Off Campus Location
CONTACT:
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