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DTSTART:20070311T020000
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BEGIN:VEVENT
DTSTAMP:20250320T163633
DTSTART;TZID=America/Detroit:20250418T120000
SUMMARY:Workshop / Seminar:A cross-century pursuit of propagating waves of cell death
DESCRIPTION:Large-scale cell death is commonly observed during organismal development and in human pathologies. These cell death events extend over great distances to eliminate large populations of cells\, raising the question of how cell death can be coordinated in space and time. One mechanism that enables long-range signal transmission is trigger waves\, but how this mechanism might be used for death events in cell populations remains unclear. Here we demonstrate that ferroptosis\, an iron- and lipid-peroxidation-dependent form of cell death\, can propagate across human cells over long distances (≥ 5 mm) at constant speeds (around 5.5 μm/min) through trigger waves of reactive oxygen species (ROS). Chemical and genetic perturbations indicate a primary role of ROS feedback loops (Fenton reaction\, NADPH oxidase signaling and glutathione synthesis) in controlling the progression of ferroptotic trigger waves. We show that introducing ferroptotic stress through suppression of cystine uptake activates these ROS feedback loops\, converting cellular redox systems from being monostable to being bistable and thereby priming cell populations to become bistable media over which ROS propagate. Furthermore\, we demonstrate that ferroptosis and its propagation accompany the massive\, yet spatially restricted\, cell death events during muscle remodeling of the embryonic avian limb\, substantiating its use as a tissue-sculpting strategy during embryogenesis. Our findings highlight the role of ferroptosis in coordinating global cell death events\, providing a paradigm for investigating large-scale cell death in embryonic development and human pathologies.
UID:128871-21861721@events.umich.edu
URL:https://events.umich.edu/event/128871
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biophysics
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250421T113230
DTSTART;TZID=America/Detroit:20250418T120000
DTEND;TZID=America/Detroit:20250418T160000
SUMMARY:Exhibition:Bloody Work: Lexington and Concord 1775
DESCRIPTION:The William L. Clements Library is pleased to announce a forthcoming exhibition in recognition of the 250th Anniversary of the military hostilities that began the American Revolutionary War. The Battles of Lexington and Concord are firmly established in American memory as the culmination of a range of governmental\, political\, economic\, and social tensions that amplified in the decade leading up to 1775. In this exhibit\, visitors will have the opportunity to see original historical manuscript letters\, documents\, newspapers\, and artwork that reveal aspects of the bloody work of Empire and individual alike in April 1775.\n\nAmong the items on display will be Commander in Chief of the British Army\, General Thomas Gage's draft orders for the Concord Expedition\, April 18\, 1775\; a bundle of letters collected by former Sons of Liberty supporter Dr. Benjamin Church\, which he secretly turned over to British Army intelligence\; letters by Silas Deane\, John Hancock\, and Rachel Revere\; and much more.\n\nOpen weekdays from 12-4 pm.
UID:134875-21875505@events.umich.edu
URL:https://events.umich.edu/event/134875
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Americana,american culture,american history,Ann Arbor,Exhibit,Exhibition,Free,history,libraries,Library
LOCATION:William Clements Library
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250404T180837
DTSTART;TZID=America/Detroit:20250418T120000
DTEND;TZID=America/Detroit:20250418T130000
SUMMARY:Lecture / Discussion:CSEAS Friday Lecture Series. Fact Checking in Low-Resource Languages: A New Dataset and Transformer Model for the Burmese Language
DESCRIPTION:Misinformation on Burmese social media is a serious problem\, fueling hate speech and violence\, especially during the 2017 Rohingya genocide. Despite efforts by platforms like Facebook to restrain harmful content using Burmese-speaking moderators and some automatic tools\, a limited number of moderators working for these platforms are often overwhelmed by the amount of content to be fact checked. The goal of this research is to leverage AI and machine learning to create automatic fact checking tools to assist human moderators. The challenge we encountered is the lack of training data and effective machine learning models. We addressed this challenge by creating a large dataset and natural language processing (NLP) models for fact checking in Burmese. We translated the Fake News Challenge (FNC-1) dataset (originally in English) into Burmese using machine translation. We then trained and evaluated three BERT-based classifiers for fact checking in Burmese using the machine-translated dataset. We also evaluated the three classifiers using a manually annotated Burmese dataset for a comparison with machine-translated data. The top-performing model achieves high predictive performance on both machine-translated and manually annotated data\, with an accuracy comparable to that of human fact checkers. Our results show that BERT-based models trained specifically for Burmese perform better than those trained with multi-lingual data (i.e.\, general multilingual models). This research presents a crucial first step toward creating datasets and tools for fact checking in Burmese and other low resource languages to combat misinformation online.\n   \n   Lwin Moe is currently a Ph.D. candidate in Computer Science at York University’s Lassonde School of Engineering. As part of his Ph.D. dissertation\, he studies fact checking and misinformation detection using machine learning in general\, and natural language processing (NLP) in particular.\n\nAccommodation: If there is anything we can do to make this event accessible to you\, please contact us. Please be aware that advance notice is necessary as some accommodations may require more time for the university to arrange.\n   Email: -- cseas@umich.edu
UID:133716-21873476@events.umich.edu
URL:https://events.umich.edu/event/133716
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:center for southeast asian studies,Cseas Lecture Series,Discussion,Lecture,Southeast Asia
LOCATION:Weiser Hall - 110
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20260112T144046
DTSTART;TZID=America/Detroit:20250418T120000
DTEND;TZID=America/Detroit:20250418T123000
SUMMARY:Well-being:Heartfulness Guided Meditation
DESCRIPTION:Heartfulness Guided Meditation is a weekly\, drop-in program designed to help you Mental well-being. \n\nAll U-M students\, faculty\, and staff are welcome to participate in guided meditation practice with a trainer every Friday at noon over Zoom (details to join are provided below). No prior experience with meditation is required. \n\n*What will you learn?*\n\nThe guided meditation practice involves three simple steps: relaxation\, rejuvenation\, and meditation.\n\nRelaxation brings your body to a calm\, steady posture creating a stillness at the physical level\, and prepares the mind for meditation. We follow this with a rejuvenation method to detox the mind to let go of stress and complex emotions\, and will leave you feeling light and refreshed. Lastly\, learning to meditate by being mindful of your heart will connect you with yourself by listening to your heart’s voice. \n\n*Why Meditate?*\n\nWhile physical fitness keeps our bodies in shape\, meditation is an exercise for the mind and mental wellness. In addition to the measurable benefits mentally and physically\, many people benefit from an unquantifiable inner poise and harmony. \n\n*Please take Learn to Meditate session if you are new to the practice. These sessions are offered Monthly.* https://events.umich.edu/event/128708\n\n*Event Details*\n\nHeartfulness Guided Meditation \nFridays from 12-12:30 p.m. ET (except during university season days / holidays)\nJoin Via Zoom Meeting\nRegister to receive Passcode (see “Related links”\n\n\nThis wellness program is coordinated by ITS Teaching & Learning and provided at no cost by heartfulness.org.
UID:88544-21865085@events.umich.edu
URL:https://events.umich.edu/event/88544
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Free,Health & Wellness,Well-being
LOCATION:Off Campus Location
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20250217T162931
DTSTART;TZID=America/Detroit:20250418T120000
DTEND;TZID=America/Detroit:20250418T130000
SUMMARY:Careers / Jobs:LSA Internship Scholarship Workshop
DESCRIPTION:Are you an LSA student currently looking for ways to fund your summer internship? Join us for an in-person workshop centered around the LSA Internship Scholarship. During this workshop we will walk through the application process for both the scholarship and the ALA course\, review the application requirements\, and offer an opportunity for you to ask any lingering questions you have about the scholarship process. Food will be provided!\n\n\n\nPlease note that the priority deadline is April 1! \n\n\n\nWe will be hosting sessions on:\n\nApril 18\, from 12-1pm\, Virtual\n\nMay 1\, 12-1pm\, In-Person
UID:132843-21871949@events.umich.edu
URL:https://events.umich.edu/event/132843
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Career,Workshop,Scholarship,Internship
LOCATION:Off Campus Location
CONTACT:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20250226T172147
DTSTART;TZID=America/Detroit:20250418T120000
DTEND;TZID=America/Detroit:20250418T130000
SUMMARY:Workshop / Seminar:MCDB Seminar> Using genetic variants to understand TRIO dysfunction in neurodevelopmental disorders
DESCRIPTION:Host: Morgan DeSantis
UID:132914-21872064@events.umich.edu
URL:https://events.umich.edu/event/132914
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biosciences,Basic Science,Biology,Natural Sciences,Bsbsigns,Research,Science
LOCATION:Biological Sciences Building - 1060
CONTACT:
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