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DTSTART:20070311T020000
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BEGIN:VEVENT
DTSTAMP:20250110T130940
DTSTART;TZID=America/Detroit:20250207T120000
DTEND;TZID=America/Detroit:20250207T160000
SUMMARY:Exhibition:More than Gray: Reimagining Early America in Full Color
DESCRIPTION:The American past was lived in full color\, but this vibrant history can be easily missed in surviving evidence. You can’t deny that there’s something about a black-and-white photograph that feels… stuffy. With portraits showing people with their shirts buttoned right to the neck and everything in shades of gray and brown\, our imaginations can incline to thinking of the past as a bit staid\, if not downright dull. But look a little closer\, and you’ll see signs that the fashion choices available to those who came before us were more colorful than you might first think. From the fabrics they wore\, to the games they played\, or the books they read\, their world was alive with bright hues. This exhibit invites you to reimagine history with a fuller color palette and picture the vibrancy and joy that just might be hidden behind the unsmiling photographs.\n\nExhibition opening weekdays from 12-4.
UID:130748-21866738@events.umich.edu
URL:https://events.umich.edu/event/130748
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:american history,history,Free,Exhibition,Exhibit,american culture,libraries,Library
LOCATION:William Clements Library
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250124T095054
DTSTART;TZID=America/Detroit:20250207T120000
DTEND;TZID=America/Detroit:20250207T130000
SUMMARY:Workshop / Seminar:Physical and molecular mechanisms of engineered T cell activation
DESCRIPTION:Cytotoxic T cells expressing engineered chimeric antigen receptors (CARs) consolidate key components of native T cell triggering machinery into a single transmembrane receptor capable of scanning for specific pathogenic markers. These programmable therapeutics are capable of identifying and destroying target cells but have had limited clinical success and often exhibit off-target toxicities. The mechanistic determinants for threshold setting in CAR T cells are still poorly understood and are expected to inform future improvements of the therapies. Signaling onset\, at the cell surface\, may be tuned by spatiotemporal\, topographic\, mechanical\, and chemical parameters. Using an in vitro cell:cell killing assay using low CAR T cell:target cell ratios\, we show that small numbers of binding interactions by CAR T cells are sufficient to induce target cell death. This single cell sensitivity is enhanced by mechanical features of the microenvironment. To explore the potency of individual cells\, we mapped CAR T cell inputs to cellular activation and cytotoxic responses using a single molecule in vitro reconstitution assay. We monitored the collection of binding interactions that culminate in polarization of lytic granules that are trafficked to the intercellular junction and may undergo exocytosis to release cytolytic factors. We found that\, surprisingly\, some CAR T cells mobilize cytotoxic responses to a small number of antigenic binding events\, suggesting a different molecular activation threshold than previously appreciated. These characteristics bear an uncanny resemblance to the native T cell receptor (TCR)\, leading us to explore how the native receptor may be contributing to CAR T cell function. I will discuss how mechanochemical features of the CAR T cell:target cell junction tune the activation setpoint and our efforts to map the molecular mechanisms underlying the mobilization of the cytotoxic response.
UID:125333-21854753@events.umich.edu
URL:https://events.umich.edu/event/125333
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biophysics
LOCATION:Chemistry Dow Lab - 1640
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250222T063235
DTSTART;TZID=America/Detroit:20250207T120000
DTEND;TZID=America/Detroit:20250207T130000
SUMMARY:Careers / Jobs:Registered Nurse Lunch & Learn with Sentara
DESCRIPTION:Let's have lunch together!I'm Christina Berry\, Sentara's RN Student Liaison and if you're curious about Sentara and would like to network with me\, this is our time to do just that! Join me at noon on Monday\, February 3: https://bit.ly/48tOGUL Let’s talk about how to apply\, Sentara’s Nurse Residency Program\, Summer internships\, benefits of working with Sentara\, and anything else you might have questions about!Can’t attend this event?Lunch &amp\; Learn sessions are currently scheduled weekly from January to March 2025.  Don't forget to look for Sentara sponsored events that can be pivotal in your job search!  Make that all-important face-to-face connection with Sentara hiring managers &amp\; recruiters.  Check for upcoming events at your preferred location at www.sentaracareers.com/events.I look forward to connecting with you soon!Benefits: Sentara offers an attractive array of full-time benefits to include Medical\, Dental\, Vision\, Paid Time Off\, Sick\, Tuition Reimbursement\, a 401k/403B with matching funds\, 401a\, Performance Plus Bonus\, Career Advancement Opportunities\, Work Perks\, and more. Our success is supported by a family-friendly culture that encourages community involvement and creates unlimited opportunities for development and growth. Be a part of an excellent healthcare organization that cares about our People\, Quality\, Patient Safety\, Service\, and Integrity. Join a team that has a mission to improve health every day and a vision to be the healthcare choice of the communities that we serve!
UID:130603-21866434@events.umich.edu
URL:https://events.umich.edu/event/130603
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250203T142143
DTSTART;TZID=America/Detroit:20250207T120000
DTEND;TZID=America/Detroit:20250207T130000
SUMMARY:Lecture / Discussion:Sacred Glaciers: Exploring 4000 Year Old Shrines of Camelid Herders in the High Altitudes of the Peruvian Andes
DESCRIPTION:Ceremonies and rituals in herding societies are practices believed to protect herders and their flocks. These rituals also help maintain social reproduction and cope with the uncertainties surrounding flock fertility. This phenomenon has been documented in modern camelid herders in the Andes. Rich ethnohistorical and ethnographic data reveal the significance of worshiping deities\, mythical heroes\, and ancestral spirits in llama herder communities. However\, our understanding of these ceremonies and rites during camelid domestication—when hunter-gatherers transitioned to herding—remains limited. This talk will present findings from a 4\,000-year-old ceremonial center that served as a gathering place for small groups of herders in the upper Santa Valley\, Peru. We will explore the worship of glaciers personified as megalithic stones believed to help flock fertility and protect herders and their animals.
UID:132247-21870659@events.umich.edu
URL:https://events.umich.edu/event/132247
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Archaeology,Anthropology
LOCATION:School of Education - 1322
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250806T162329
DTSTART;TZID=America/Detroit:20250207T120000
DTEND;TZID=America/Detroit:20250207T123000
SUMMARY:Film Screening:Sea Monsters
DESCRIPTION:The film follows a curious and adventurous Dolichorhynchops – familiarly known as a ‘dolly’ – as she travels through the most dangerous oceans in history. Along the way\, she encounters long-necked plesiosaurs\, giant turtles\, enormous fish\, fierce sharks\, and the most dangerous sea monster of all– the mosasaur.
UID:121866-21866320@events.umich.edu
URL:https://events.umich.edu/event/121866
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:natural history museum,museums,Museum
LOCATION:Museum of Natural History - Planetarium & Dome Theater
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20250121T181724
DTSTART;TZID=America/Detroit:20250207T120000
DTEND;TZID=America/Detroit:20250207T123000
SUMMARY:Performance:Vinson Lam\, carillon
DESCRIPTION:Vinson Lam performs on the Charles Baird Carillon\, an instrument of 53 bronze bells located inside the Burton Memorial Tower. The largest bell\, which strikes the hour\, weighs 12 tons\, while the smallest bell\, 4½ octaves above\, weighs just 15 pounds.\n\nThirty-minute recitals are performed on the Charles Baird Carillon at noon every weekday that classes are in session\, followed by visitor Q&A with the carillonist. The bell chamber may be accessed via a combination of elevator and stairs. Take the elevator to the highest floor possible (floor 8)\, and then climb two flights of stairs (39 steps) to the bell chamber (floor 10). Hearing protection earmuffs are provided for visitors. Be prepared to walk on ice and snow in the bell chamber during winter. Built in 1936\, the Charles Baird Carillon is not ADA accessible. Visitors with mobility concerns are invited to visit the Lurie Carillon.
UID:131545-21868743@events.umich.edu
URL:https://events.umich.edu/event/131545
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Talk,Music,Free
LOCATION:Burton Memorial Tower
CONTACT:
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