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DTSTART:20070311T020000
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BEGIN:VEVENT
DTSTAMP:20261028T032144
DTSTART;TZID=America/Detroit:20261103T093000
DTEND;TZID=America/Detroit:20261103T110000
SUMMARY:Workshop / Seminar:Property Control & Property Disposition Roadshow
DESCRIPTION:If you’re interested in learning more about U-M capital equipment\, the university’s biennial equipment inventory\, disposal processes\, or anything else related to Property Control and Property Disposition\, we hope you’ll join us at one of our upcoming in-person roadshows this fall!\nBeyond learning more about U-M capital equipment guidelines\, biennial capital equipment inventory process steps\, and a capital asset’s lifecycle\, the Property Control and Disposition team will be on hand to answer your questions. The roadshows are open to the entire U-M community. We look forward to seeing you there!\n
UID:152961-21914869@events.umich.edu
URL:https://events.umich.edu/event/152961
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261028T003234
DTSTART;TZID=America/Detroit:20261103T100000
DTEND;TZID=America/Detroit:20261103T110000
SUMMARY:Careers / Jobs: International Students Career Series: How to Build Your Network
DESCRIPTION:You can’t start networking unless you know where to begin! For many international students\, the idea of approaching and interacting with professionals in the U.S. can feel intimidating — and that’s okay. In this interactive workshop\, you’ll learn practical strategies forfinding and connecting with contacts\, as well as how to conduct informational interviews. These conversations let you explore careers and companies by hearing directly from professionals about their day-to-day work — without the pressure of a formal job interview.Networking is all about building genuine relationships\, and often those connections can lead to exciting opportunities down the road. This session is open to all students. For a head start\, check out our website before attending to familiarize yourself with the basics.Review Networking Resources: https://www.youtube.com/watch?v=8PHpx31Amwc&amp\;t=2shttps://careercenter.umich.edu/article/networking-resources This event's information is shown in Handshake as well as on the Happening @ Michigan calendar so that it will be seen by a larger number of U-M Students. You can only register to attend this event within Handshake. If you'd liketo indicate that you'll be attending this event and see more details\, please go to this webpage: https://umich.joinhandshake.com/events/2039291/share_previewWe want to ensure full and equitable participation in our events. If an accessibility accommodation would promote your full participation in this event\, please indicate your accommodation requirements via the link below\, preferably at least 14 days prior to the program to ensure sufficient time for arranging your requested accommodation(s) or exploring suitable alternatives. If you have any questions regarding access to our programs\, please don't hesitate to reach out to Jocelyn Gaydos at jmgaydos@umich.edu. Accessibility accommodation form: https://forms.gle/FmFn35ZLxJ8kvPfSA #UCC
UID:153438-21915858@events.umich.edu
URL:https://events.umich.edu/event/153438
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:
LOCATION:
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261028T032145
DTSTART;TZID=America/Detroit:20261103T100000
DTEND;TZID=America/Detroit:20261103T110000
SUMMARY:Workshop / Seminar:MADS Application Tips Webinar
DESCRIPTION:We want you to have all the information you need to make informed decisions about your education and your future.\nMADS Admissions & Recruitment coordinator Kelly Barger leads an application tips webinar with a live Q&A. Attendees will hear about the MADS program\, the skills-based admission process\, what's required as part of the application\, and how the placement process works. Please join us to get your questions answered\, and benefit from the curiosity of like-minded peers!
UID:144393-21907915@events.umich.edu
URL:https://events.umich.edu/event/144393
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Virtual
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20260930T145225
DTSTART;TZID=America/Detroit:20261103T110000
DTEND;TZID=America/Detroit:20261103T130000
SUMMARY:Presentation:FA26 MSminor Colloquium
DESCRIPTION:The Museum Studies Minor program is hosting its Fall 2026 Colloquium.  Museum Studies Minor students will share their experience during their internships.
UID:153123-21915121@events.umich.edu
URL:https://events.umich.edu/event/153123
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:museum studies,museum studies program
LOCATION:Tisch Hall - G026
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261028T032137
DTSTART;TZID=America/Detroit:20261103T110000
DTEND;TZID=America/Detroit:20261103T120000
SUMMARY:Workshop / Seminar:FSL - Joint Panhel/IFC Sober Monitor Training (SMT)
DESCRIPTION:
UID:144887-21917048@events.umich.edu
URL:https://events.umich.edu/event/144887
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:1443 Washtenaw Ave Ground Floor
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261028T032145
DTSTART;TZID=America/Detroit:20261103T110000
DTEND;TZID=America/Detroit:20261103T140000
SUMMARY:Workshop / Seminar:IPE Study Abroad Fair
DESCRIPTION:IPE will host a STUDY ABROAD FAIR- for engineering students on Tuesday\, November 3 in Pierpont Commons. Stop by and talk with advisors and students who studied abroad to learn more!Plus Games & Prizes!ATtend to Win a $1\,000 travel grant
UID:151306-21911347@events.umich.edu
URL:https://events.umich.edu/event/151306
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Sessions
LOCATION:Pierpont Commons
CONTACT:
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BEGIN:VEVENT
DTSTAMP:20261021T141949
DTSTART;TZID=America/Detroit:20261103T110000
DTEND;TZID=America/Detroit:20261103T120000
SUMMARY:Workshop / Seminar:MCDB Dissertation Defense Seminar> The Regulation and Interactome of an H4K20-Specific Demethylase in Dosage Compensation of C. elegans
DESCRIPTION:In species that use sex chromosomes to differentiate between its sexes\, there is a difference in sex chromosome number and the number of gene copies which results in unequal gene dosage. In species that cannot tolerate this imbalance in gene dosage\, the dosage compensation process is applied in which the gene expression levels between the two sexes are made equal. In mammals\, female somatic cells (XX) have one X chromosome inactivated to equalize to the single X chromosome in male somatic cells (XY). In C. elegans\, hermaphrodites (XX) downregulate both X chromosomes by half to equalize to the single X chromosome in their male counterparts (XO). \n\nDosage compensation in C. elegans is conducted primarily by the Dosage Compensation Complex (DCC)\, a multimeric set of proteins including a CondensinIDC complex and several additional proteins that bind\, compact and downregulate the X chromosomes in hermaphrodites. One of the non-condensin proteins in the DCC is DPY-21\, a Histone 4 Lysine 20 (H4K20)- specific demethylase. DPY-21 binds to the hermaphroditic X chromosomes and converts H4K20 di-methylation (H4K20me2) into mono-methylation (H4K20me1). This results in the enrichment of the repressive H4K20me1 mark on the X and the transcriptional downregulation of the X chromosomes. Although DPY-21 is part of the DCC\, it localizes to the X chromosomes at a later stage of embryogenesis and does not bind mitotic chromosomes\, contrasting to the other DCC components. Additionally\, DPY-21 has been shown to have a DCC-independent role in the germline where dosage compensation in unrequired. This drives the question of the regulation of DPY-21 and its interactors in addition to the DCC. \n\nThe first part of my thesis is the characterization of DPY-21 regulation through phosphorylation. Using CRISPR/Cas9 site-directed mutagenesis\, I generated a dpy-21 phosphomutant C.elegans strain by mutating the phosphosites of DPY-21 into Alanines to render them non-phosphorylatable. Through physiological assays\, I found that the dpy-21 phosphomutant C. elegans strain has defects in embryogenesis and larval stages. In embryogenesis\, the phosphomutations disrupts DPY-21’s localization to the X chromosomes and delays the enrichment of H4K20me1 to the X chromosomes. Through biochemical and imaging analysis\, I demonstrate that the global levels of 4K20me1 is increased in the phosphomutant strain\, suggesting that the mutant protein may be hyperactive. At the larval stages\, the dpy-21 phosphomutant strain exhibits developmental delay and increased propensity to form dauers. These defects are resolved by  adulthood which implies that DPY-21’s activity is most critical in the embryonic and larval stages.\n\nThe second part of my work revealed novel interactors  of DPY-21. I conducted an immunoprecipitation-mass spectrometry (IP-MS  ) on DPY-21 to establish its interacting partners and found the kinase SPK-1 to be a top interactor of DPY-21. In spk-1 mutants\, there is delayed H4K20me1 enrichment on the X chromosomes in embryogenesis which ultimately results in disrupted H4K20me1 enrichment on the X chromosomes in adults. This shows that SPK-1 may regulate DPY-21 although this may be indirect. Taken together\, my work has characterized a novel dpy-21 mutant for the field that leads to its hyperactivity in generating H4K20me1 globally as well as the novel interactor SPK-1 that may regulate DPY-21.
UID:153927-21916755@events.umich.edu
URL:https://events.umich.edu/event/153927
CLASS:PUBLIC
STATUS:CONFIRMED
CATEGORIES:Biology,Bsbsigns,Graduate Students,Thesis Defense
LOCATION:Biological Sciences Building - 1010
CONTACT:
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