[ { "id":"145728-21897738", "datetime_modified":"20260219T101007", "datetime_start":"20260312T150000", "datetime_end":"20260312T160000", "has_end_time":1, "date_start":"2026-03-12", "date_end":"2026-03-12", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Biomedical Engineering (BME 500) Seminar Series", "occurrence_title":"", "combined_title":"Biomedical Engineering (BME 500) Seminar Series: \"Engineering immunotherapies for autoimmunity and cancer,\" with Cory Berkland, Ph.D.", "event_subtitle":"\"Engineering immunotherapies for autoimmunity and cancer,\" with Cory Berkland, Ph.D.", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Engineering immunotherapies for autoimmunity and cancer\n\nAbstract:\nEffective delivery of drugs to direct immune responses requires an understanding of biological barriers, physicochemical properties of drug molecules, formulation and transport in vivo. Designing molecular structures that persist at the administration site or that promote drainage to regional lymphatic networks may enhance immune responses while sparing immune-related adverse events. Here, drug transport and local elimination mechanisms will be overviewed. Then, examples of molecular designs to direct drug delivery will be presented. Autoimmune therapies were designed by our lab to promote the drainage of autoantigens to secondary lymphoid organs to treat autoimmune diseases. Specifically, the size and solubility of these molecular constructs were tuned to promote access to the lymphatic compartment and induce immune tolerance in mouse models of type 1 diabetes. Our lab has also recently explored the design of immunostimulants that persist in tumor tissue after intratumoral\/perilesional injection. Intratumoral immunotherapy is proposed to work synergistically with checkpoint inhibitors making a nonresponsive \u2018cold\u2019 tumor \u2018hot\u2019 by recruiting and activating tumor infiltrating lymphocytes. This approach can suffer from systemic immune-related adverse reactions, however, if enough immunostimulant escapes the site of administration. Data on the use of electrostatic mechanisms to promote tumor retention will be presented. These examples underscore the need for rational design of drug molecules or formulations based upon the route of delivery and biological barriers encountered. \n\nBio:\nCory Berkland is the Mark and Becky Levin Professor in the Departments of Biomedical Engineering and Chemistry at Washington University in Saint Louis. Previously, he was the Solon E. Summerfield Professor in the Department of Pharmaceutical Chemistry and in the Department of Chemical Engineering at The University of Kansas. He received MS and PhD degrees from the Department of Chemical and Biomolecular Engineering at the University of Illinois in Urbana-Champaign and a BS degree in Chemical Engineering from Iowa State University in Ames. His lab studies pharmaceuticals and materials with an emphasis on molecular design and transport in the human body. He is a co-founder of Orbis Biosciences (acquired by Adare Pharmaceuticals), Savara Pharmaceuticals (NASDAQ:SVRA), Bond Biosciences, Kinimmune, Axioforce, and other start-ups. He has served as a board member, executive, and fundraiser for these companies.", "occurrence_notes":"https:\/\/umich.zoom.us\/j\/94337625486", "guid":"145728-21897738@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145728", "building_id":"1000406", "building_name":"Lurie Biomedical Engineering (formerly ATL)", "building_official_id":1000406, "campus_maps_id":"7", "campus_maps_link_path":"lurie-ann-and-robert-h-biomedical-engineering-bld", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/lurie-ann-and-robert-h-biomedical-engineering-bld", "room":"1130", "location_name":"Lurie Biomedical Engineering (formerly ATL)", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], "website":"http:\/\/bme.umich.edu", "links":[ { "type":"other", "url":"http:\/\/bme.umich.edu", "title":null } ], "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", "website":"https:\/\/www.facebook.com\/profile.php?id=100094127215673" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "image_description":"A speaker talking to a group of students in a classroom.", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/02\/event_145728_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/02\/event_145728_original-1.jpg" }, "qr_code_url":"http:\/\/events.umich.edu\/event\/145728\/qrcode.png", "occurrence_count":1, "first_occurrence":21897738 } , { "id":"146152-21898595", "datetime_modified":"20260313T155924", "datetime_start":"20260319T150000", "datetime_end":"20260319T160000", "has_end_time":1, "date_start":"2026-03-19", "date_end":"2026-03-19", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Biomedical Engineering (BME 500) Seminar Series", "occurrence_title":"", "combined_title":"Biomedical Engineering (BME 500) Seminar Series: \"Patterned Biomaterials: New Tools to Probe and Control Complex Biological Systems,\" with Jouha Min, Ph.D.", "event_subtitle":"\"Patterned Biomaterials: New Tools to Probe and Control Complex Biological Systems,\" with Jouha Min, Ph.D.", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Patterned Biomaterials: New Tools to Probe and Control Complex Biological Systems\n\nAbstract:\nEngineered materials and molecular sensing tools are transforming how we study and control complex biological systems. Yet many technologies operate at a single scale\u2014either manipulating cellular environments without molecular precision or profiling molecular signals without spatial or mechanical context. My lab addresses this challenge through chemical and materials innovation, developing scalable platforms that integrate molecular design with quantitative analysis. We focus on two complementary directions: (1) physico-chemical design of soft interfaces with tunable nanoscale architecture and dynamic mechanics to probe and control material\u2013biology interactions, and (2) biomolecular sensing platforms that combine polymer chemistry, optical or electrochemical detection, and data-driven analysis for accessible diagnostics. In this talk, I will highlight two representative efforts: nature-inspired nanopatterned coatings with dynamically tunable surface topography for long-term antibacterial activity, and integrated bioanalytical sensing technologies for early, point-of-care detection of sepsis. \n\nBio:\nDr. Jouha Min is an Assistant Professor in the Department of Chemical Engineering at University of Michigan. She received her B.S. in Chemical Engineering from Cornell University in 2010 and her Ph.D. in Chemical Engineering from MIT, where she was advised by Paula Hammond and Richard Braatz. She conducted her postdoctoral research with Ralph Weissleder at Harvard Medical School and Massachusetts General Hospital, where she worked at the interface of engineering, biology, and clinical translation. Dr. Min\u2019s research group applies core principles of chemical and biological engineering\u2014including transport phenomena, reaction kinetics, materials synthesis, and systems-level analysis\u2014to develop new methodologies for probing and controlling material\u2013biology interactions across three-dimensional space and time. Her work aims to establish a quantitative and mechanistic foundation for transformative advances in disease diagnosis, treatment, and prevention. She is the recipient of several honors, including the NSF CAREER Award (2025), the NIH R35 MIRA Award (2025), and the V Foundation V Scholar Award (2023).", "occurrence_notes":"https:\/\/umich.zoom.us\/j\/94337625486", "guid":"146152-21898595@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/146152", "building_id":"1000406", "building_name":"Lurie Biomedical Engineering (formerly ATL)", "building_official_id":1000406, "campus_maps_id":"7", "campus_maps_link_path":"lurie-ann-and-robert-h-biomedical-engineering-bld", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/lurie-ann-and-robert-h-biomedical-engineering-bld", "room":"1130", "location_name":"Lurie Biomedical Engineering (formerly ATL)", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], "website":"http:\/\/bme.umich.edu", "links":[ { "type":"other", "url":"http:\/\/bme.umich.edu", "title":null } ], "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", 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Winter\/Spring 2026 Seminar Series: \"Wnt you thought you knew about Wnt signaling\"", "event_subtitle":"", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Stephanie Grainger, Ph.D.\nAssistant Professor\nCell Biology\nVan Andel Institute", "occurrence_notes":null, "guid":"145982-21898223@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145982", "building_id":"1005037", "building_name":"Taubman Biomedical Science Research Building", "building_official_id":1005037, "campus_maps_id":"509", "campus_maps_link_path":"alfred-a-taubman-biomedical-science-research-bldg", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/alfred-a-taubman-biomedical-science-research-bldg", "room":"ABC Seminar Rooms", "location_name":"Taubman Biomedical Science Research Building", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], 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"datetime_modified":"20260220T102635", "datetime_start":"20260326T100000", "datetime_end":"20260326T114500", "has_end_time":1, "date_start":"2026-03-26", "date_end":"2026-03-26", "time_start":"10:00:00", "time_end":"11:45:00", "time_zone":"America\/Detroit", "event_title":"SCSAP Special Research Seminar and Town Hall Event", "occurrence_title":"", "combined_title":"SCSAP Special Research Seminar and Town Hall Event: Aviv Regev, PhD, Genentech", "event_subtitle":"Aviv Regev, PhD, Genentech", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"SCSAP Special Research Seminar and Town Hall Discussion Event\nDate: Thursday, March 26, 2026\nLocation: Live In-Person Only (Will not be streamed or recorded)\n NCRC Building 18, Dining Hall\nFREE TO ALL, Everyone is Welcome, \nLite Refreshments provided\n\nFEATURING: Dr. Aviv Regev, Executive Vice President and Head of Genentech Research and Early Development and Executive Committee of the Human Cell Atlas\n\n*PLEASE REGISTER FOR THIS EVENT*\n\nTwo Events of Interest: \n\n10:00\u201310:45 AM- Talk Title: \u201cTowards Unified Cell and Tissue Oracles\u201d- Featuring Dr. Regev- Hosted by SCSAP \n\n11:00\u201311:45 AM Town Hall Discussion Featuring Dr. Regev and an invited faculty panel \u2013 event will cover several topics such as the future of single cell spatial-omics, strategies for productive collaboration, AI development of new drugs.", "occurrence_notes":null, "guid":"145768-21897796@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145768", "building_id":"", "building_name":"North Campus Research Complex Building 18", "building_official_id":0, "campus_maps_id":"595", "campus_maps_link_path":"north-campus-research-complex-building-18", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/north-campus-research-complex-building-18", "room":"Dining Hall", "location_name":"North Campus Research Complex Building 18", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], "website":"https:\/\/forms.gle\/HszvbgtbRx1bgSfY7", "links":[ { "type":"registration", "url":"https:\/\/forms.gle\/HszvbgtbRx1bgSfY7", "title":"Registration" }, { "type":"other", "url":"https:\/\/singlecellspatialanalysis.umich.edu\/special-research-seminar\/", "title":"Learn More Here" } ], "sponsors":[ { "group_name":"Single Cell Spatial Analysis Program (SCSAP)", "group_id":"4668", "website":"" }, { "group_name":"Life Sciences Institute (LSI)", "group_id":"1067", "website":"https:\/\/twitter.com\/UMLifeSciences" }, { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/02\/event_145768_original-1.png", "image_description":"SCSAP Aviv Regev Seminar Flyer", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/02\/event_145768_original-1.png", 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(histotripsy)\n\nAbstract:\nHistotripsy is a non-invasive, non-thermal, and non-ionizing tissue ablation method that was recently (Oct. 2023) approved by the FDA for the non-invasive treatment of liver tumors. Histotripsy is a platform technology, with the potential to enable truly non-invasive surgery for many applications throughout the body, from the abdominal region to the limbs, brain, and spine. However, we currently cannot perform histotripsy everywhere in the body due to limitations in our ability to safely deliver sufficient acoustic energy to the target through heterogeneous, attenuating bodily tissues. In this talk, I will present my work to (1) numerically model and quantify acoustic energy delivery to the body, and (2) optimize acoustic energy delivery through complex tissues via adaptive signal processing methods. I will discuss how these technologies will help expand the region where we can perform histotripsy, broaden the population of patients who can receive histotripsy treatment, and enable novel histotripsy applications. \n\nBio:\nDr. Ellen Yeats is a Postdoctoral Research Fellow in the Department of Biomedical Engineering and member of the Histotripsy Lab, where she is advised by Dr. Zhen Xu and Dr. Timothy Hall. She received her B.S.E. in Biomedical Engineering from Vanderbilt University in 2017 and her Ph.D. in Biomedical Engineering from the University of Michigan in 2024. In 2025, Dr. Yeats was awarded an NIH T32 Training Fellowship through the Michigan Translational Imaging Program (M-TIP) with the Department of Radiology of University of Michigan Medicine, where she is working with Dr. Shane Wells to develop improved imaging guidance and targeting for histotripsy. Through her research, Dr. Yeats develops technologies that optimize the targeting and delivery of acoustic energy to the body for histotripsy. Her work aims to improve current clinical histotripsy treatments in the liver and to expand histotripsy applications to new, challenging targets in the pelvis and spine.", "occurrence_notes":"https:\/\/umich.zoom.us\/j\/94337625486", "guid":"146698-21899492@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/146698", "building_id":"1000406", "building_name":"Lurie Biomedical Engineering (formerly ATL)", "building_official_id":1000406, "campus_maps_id":"7", "campus_maps_link_path":"lurie-ann-and-robert-h-biomedical-engineering-bld", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/lurie-ann-and-robert-h-biomedical-engineering-bld", "room":"1130", "location_name":"Lurie Biomedical Engineering (formerly ATL)", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], "website":"http:\/\/bme.umich.edu", "links":[ { "type":"other", "url":"http:\/\/bme.umich.edu", "title":null } ], "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", "website":"https:\/\/www.facebook.com\/profile.php?id=100094127215673" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "image_description":"A speaker talking to a group of students in a classroom.", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/03\/event_146698_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/03\/event_146698_original-1.jpg" }, "qr_code_url":"http:\/\/events.umich.edu\/event\/146698\/qrcode.png", "occurrence_count":1, "first_occurrence":21899492 } , { "id":"146729-21899558", "datetime_modified":"20260318T082724", "datetime_start":"20260402T150000", "datetime_end":"20260402T160000", "has_end_time":1, "date_start":"2026-04-02", "date_end":"2026-04-02", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Biomedical Engineering (BME 500) Seminar Series", "occurrence_title":"", "combined_title":"Biomedical Engineering (BME 500) Seminar Series: \"Convergence of light, devices, and molecules to detect and treat cancer,\" with Samuel Achilefu, Ph.D.", "event_subtitle":"\"Convergence of light, devices, and molecules to detect and treat cancer,\" with Samuel Achilefu, Ph.D.", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Convergence of light, devices, and molecules to detect and treat cancer\n\nAbstract:\nSurgeons traditionally rely on vision and touch to distinguish cancerous from healthy tissue, which risks incomplete tumor removal. To enhance precision, we developed Cancer Viewing Glasses (CVGs) that provide real-time intraoperative visualization of tumors and sentinel lymph nodes without disrupting the surgical workflow. CVGs detect near-infrared fluorescence (NIRF) from tumor-targeted molecular probes and project both NIRF and visible light to a head-mounted display, enabling direct access to the surgical field under normal lighting conditions. In both mouse models and cancer patients, CVGs enabled real-time image guidance for complete tumor resection, with ongoing clinical studies demonstrating improved surgical throughput and accuracy. \n\nBio:\nDr. Samuel Achilefu is the inaugural Chair and Professor of the Biomedical Engineering Department at the University of Texas Southwestern Medical Center in Dallas, Texas, USA. He also holds the Lyda Hill Distinguished University Chair and is a Professor of Radiology and the Simons Cancer Center. He is an international leader in optical and multimodal imaging, image-guided cancer surgery, portable imaging devices, and nanotechnology. His innovative research and more than 70 U.S. patents have significantly contributed to laboratory and clinical medicine. Dr. Achilefu is a member of the National Academies of Engineering and Medicine. He is also a fellow of the National Academy of Inventors, AAAS, AIMBE, and many other professional societies. He has received over 20 national and international awards, including the Briton Chance Award.", "occurrence_notes":"https:\/\/umich.zoom.us\/j\/94337625486", "guid":"146729-21899558@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/146729", "building_id":"1000406", "building_name":"Lurie Biomedical Engineering (formerly ATL)", "building_official_id":1000406, "campus_maps_id":"7", "campus_maps_link_path":"lurie-ann-and-robert-h-biomedical-engineering-bld", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/lurie-ann-and-robert-h-biomedical-engineering-bld", "room":"1130", "location_name":"Lurie Biomedical Engineering (formerly ATL)", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], "website":"http:\/\/bme.umich.edu", "links":[ { "type":"other", "url":"http:\/\/bme.umich.edu", "title":null } ], "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", "website":"https:\/\/www.facebook.com\/profile.php?id=100094127215673" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "image_description":"A speaker talking to a group of students in a classroom.", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/03\/event_146729_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/03\/event_146729_original-1.jpg" }, "qr_code_url":"http:\/\/events.umich.edu\/event\/146729\/qrcode.png", "occurrence_count":1, "first_occurrence":21899558 } , { "id":"146731-21899566", "datetime_modified":"20260318T101203", "datetime_start":"20260409T150000", "datetime_end":"20260409T160000", "has_end_time":1, "date_start":"2026-04-09", "date_end":"2026-04-09", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Biomedical Engineering (BME 500) Seminar Series", "occurrence_title":"", "combined_title":"Biomedical Engineering (BME 500) Seminar Series: \"Bioengineering Human Embryo and Organ Models,\" with Jianping Fu, Ph.D.", "event_subtitle":"\"Bioengineering Human Embryo and Organ Models,\" with Jianping Fu, Ph.D.", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Bioengineering Human Embryo and Organ Models\n\nAbstract:\nEarly human development remains largely mysterious and challenging to study. In this talk, I will describe our efforts to harness human pluripotent stem cells (hPSCs) and bioengineering approaches to create controllable models of human peri-gastrulation development and early organogenesis. These models recapitulate key in vivo developmental landmarks, including amniotic cavity formation, amniotic ectoderm-epiblast patterning, primordial germ cell specification, embryonic germ layer organization, yolk sac formation, and primitive hematopoiesis. Our current work focuses on using these controllable models as experimental platforms to dissect the molecular and genetic mechanisms underlying cell fate decisions, tissue patterning, and self-organization during human peri-gastrulation.\n\nI will also discuss our application of bioengineering tools and hPSCs to model critical aspects of early human neural development, including neural patterning in both brain and spinal cord regions, along rostrocaudal and dorsoventral axes. Ongoing projects further aim to model key features of human heart and gut tube development, as well as somitogenesis. Together, these efforts have established a suite of bioengineered human embryo and organ models with in vivo-like spatiotemporal cell differentiation and organization, providing powerful platforms for studying human development, physiology, and disease.\n\nBio:\nDr. Jianping Fu is a Professor of Mechanical Engineering at the University of Michigan whose research bridges bioengineering, stem cell biology, and developmental biology to advance understanding of human development and disease. He is internationally recognized for pioneering work in \u201cArtificial Embryos,\u201d named one of MIT Technology Review\u2019s 10 Breakthrough Technologies of 2018 and \u201cthe Method of 2023\u201d by Nature Methods. Dr. Fu has received major awards from the National Science Foundation, the American Chemical Society, the Alexander von Humboldt Foundation, and the Biomedical Engineering Society (BMES). He is an elected Fellow of AAAS, AIMBE, RSC, ASME, IAMBE, and BMES, and serves on the Governing Council of IAMBE. In addition to his research, Dr. Fu has been deeply engaged in scientific leadership and service. He served on the ISSCR Guidelines Working Group and now chairs the ISSCR Scientific Programs Committee. In recognition of his service, he received the ISSCR Public Service Award in 2025. He is currently Editor-in-Chief of npj Regenerative Medicine and serves on editorial boards of several journals including Cell Stem Cell and Biophysical Journal.", "occurrence_notes":"https:\/\/umich.zoom.us\/j\/94337625486", "guid":"146731-21899566@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/146731", "building_id":"1000406", "building_name":"Lurie Biomedical Engineering (formerly ATL)", "building_official_id":1000406, "campus_maps_id":"7", "campus_maps_link_path":"lurie-ann-and-robert-h-biomedical-engineering-bld", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/lurie-ann-and-robert-h-biomedical-engineering-bld", "room":"1130", "location_name":"Lurie Biomedical Engineering (formerly ATL)", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], "website":"http:\/\/bme.umich.edu", "links":[ { "type":"facebook", "url":"http:\/\/bme.umich.edu", "title":null } ], "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", 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"combined_title":"CPOD Winter\/Spring 2026 Seminar Series: \"How life finds a way: resilience in mammalian embryogenesis\"", "event_subtitle":"", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Sarah Bowling, Ph.D.\nAssistant Professor\nDevelopmental Biology\nStanford University", "occurrence_notes":null, "guid":"145983-21898224@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145983", "building_id":"1005037", "building_name":"Taubman Biomedical Science Research Building", "building_official_id":1005037, "campus_maps_id":"509", "campus_maps_link_path":"alfred-a-taubman-biomedical-science-research-bldg", "campus_maps_link":"https:\/\/maps.studentlife.umich.edu\/building\/alfred-a-taubman-biomedical-science-research-bldg", "room":"ABC Seminar Rooms", "location_name":"Taubman Biomedical Science Research Building", "has_livestream":0, "cost":"", "tags":["Biointerfaces"], 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"datetime_modified":"20260408T101448", "datetime_start":"20260416T150000", "datetime_end":"20260416T160000", "has_end_time":1, "date_start":"2026-04-16", "date_end":"2026-04-16", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Biomedical Engineering (BME 500) Seminar Series", "occurrence_title":"", "combined_title":"Biomedical Engineering (BME 500) Seminar Series: \"Tissue-Inspired Synthetic Biomaterials and Applications in Cancer,\" with Shelly R. Peyton, Ph.D.", "event_subtitle":"\"Tissue-Inspired Synthetic Biomaterials and Applications in Cancer,\" with Shelly R. Peyton, Ph.D.", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Tissue-Inspired Synthetic Biomaterials and Applications in Cancer\nAbstract:\nMost environments available to study how human cells behave are two-dimensional (2D). In real tissue, cells live surrounded by a three-dimensional (3D) extracellular matrix (ECM), which provides structure, drives cell function, and is dynamically remodeled by the cells within. A major limitation of the few examples of 3D cell culture environments that do exist (typically made from assemblages of proteins) is that their constituents are undefined, and they have unacceptable batch-to-batch variability. On the other end of the spectrum, the major drawbacks to using engineered, synthetic environments is their over-simplicity and lack of resemblance to real tissue. My lab\u2019s unique approach to biomaterial design is that we create cheap and easy-to-use, yet complex representations of the ECM of specific tissues. My lab\u2019s tissue-customized environments are hydrogels from synthetic polymers that replicate a tissue\u2019s 3D geometry, the stiffness of that tissue, and all the integrin-binding and protease-degradable components of the ECM of the tissue of interest. We made biomaterial designs for brain, bone marrow, omentum, and lung, and we have applied our approach to several complex problems in biology (e.g., astrocyte reactivity, mesenchymal stem cell differentiation, ovarian cancer, etc.). \n\nIn this seminar, I\u2019ll discuss how we use our engineering principles to create these environments and show how we\u2019ve begun to use them to study grand challenges in cancer biology. One of the overwhelming challenges in treating metastatic cancer is that tumors in the brain, lung, skeleton, and liver are typically drug resistant, and we do not have a good understanding of why these tumors evade therapy. The biomaterials we have built over the years are well suited for drug screening applications and to study how the extracellular microenvironment regulates the metastatic spread of cancer. \nBio:\nShelly Peyton is Professor and Department Chair of Biomedical Engineering at Tufts University. She received her B.S. in Chemical Engineering from Northwestern University in 2002 and went on to obtain her MS and PhD in Chemical Engineering from the University of California, Irvine in 2007. She was then an NIH Kirschstein post-doctoral fellow in the Biological Engineering department at MIT before starting her academic appointment in Chemical Engineering at the University of Massachusetts Amherst in 2011. At UMass she was named the Barry and Afsaneh Siadat Professional Development Professor, Armstrong Professor, Conti Fellow, and Provost Professor before moving to Tufts University to become chair of Biomedical Engineering in 2024. At Tufts, the Peyton lab is an interdisciplinary group of engineers and biologists that create bioinspired and dynamic models of human tissue with both synthetic biomaterials and decellularized tissues. They use these tissue models to 1) understand the physical relationship between metastatic cancer cells and the tissues to which they spread, 2) uncover the role of the extracellular matrix and its dynamics in drug resistant cancers, and 3) quantify how forces from traumatic brain injury damage cells within the brain. Shelly\u2019s honors include a Pew Biomedical Scholarship, an NIH New Innovator Award, an NSF CAREER award, Biomedical Engineering Society fellow, and an American Institute for Medical and Biological Engineering fellow. Outside of her research and her Chair\u2019s role, Shelly is passionate about graduate student training and diversifying the academy. She was awarded an Outstanding Teaching Award and a Diversity Award from the College of Engineering at UMass, has led an REU Site, co-directed a Biotechnology (BTP) NIH T32 training program, and was lead PI of a PREP program at UMass. Since 2013, the Peyton has continuously run an NSF- and privately funded program called Engineering the Cell, which pays high school students with no prior research experience to work in the Peyton lab for 5 weeks every summer. 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Wu, M.D., Ph.D. Professor & Director, Stanford Cardiovascular Institute, Stanford University\n4:30 Poster session\n5:30 Concluding remarks and reception\n\nAbstract:\nDrug discovery and development continue to face significant challenges, with over 90% of candidate drugs failing in clinical trials. These efficacy failures are primarily due to inherent species-specific differences, fundamental biological variances between model organisms and humans, and the limitations of existing models to accurately reflect the complexity of human disease and treatment responses. In this discussion, I will explore how the NIH and FDA are advocating for new alternative methodologies (NAMs) to reduce or replace animal testing. I will highlight recent advancements in technologies such as stem cells, organoids, and microphysiological systems (MPS), along with the roles of clinical genomics and AI\/ML. Additionally, I will examine how these platforms can collaboratively enhance our understanding of rare orphan diseases, facilitate drug discovery, support precision medicine, and enable clinical trials in a dish (CTiD).\n\nAbout the Speaker:\nJoseph C. Wu, MD, PhD is Director of Stanford Cardiovascular Institute and Simon H. Stertzer, MD, Professor of Medicine and Radiology at Stanford University. Dr. Wu received his MD from Yale University and PhD (Molecular & Medical Pharmacology) at University of California, Los Angeles. He is board certified in cardiovascular medicine. His lab works on genomics, stem cells\/organoids, AI\/ML, and drug discovery. The main goals are to (i) understand basic disease mechanisms, (ii) implement precision medicine for patients, and (iii) accelerate drug discovery via \u201cnew alternative methodologies\u201d (NAMs) and \u201cclinical trial in a dish\u201d (CTiD) concept. Dr. Wu has published >700 manuscripts with H-index of 147 on Google scholar. 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