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        "datetime_modified":"20230116T141848",
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        "time_start":"11:30:00",
        "time_end":"13:00:00",
        "time_zone":"America\/Detroit",
        "event_title":"Physics of cellular proportions",
        "occurrence_title":"",
        "combined_title":"Physics of cellular proportions: Jan\u00e9 Kondev, Brandeis University, School of Physics",
        "event_subtitle":"Jan\u00e9 Kondev, Brandeis University, School of Physics",
        "event_type":"Workshop \/ Seminar",
        "event_type_id":"21",
        "description":"Join us for this in-person talk. Coffee and snacks will be served.\r\n\r\nAbstract: Dr. Gulliver noticed 140 years ago that the size of the cell\\'s nucleus is proportional to the size of the cell. In the intervening years, similar observations have been made about other, large structures that self-assemble in the cell. This raises a fascinating question: How does the cell, which is micrometers in length, measure its size with nothing more at its disposal than nanometer-sized proteins that diffuse, on occasion bump into each other, and transiently stick together? In this talk I will describe quantitative experiments and related theory that reveal general principles of how cells control the size of their internal structures. The case of self-assembly of actin cables in budding yeast is particularly interesting in this context, as it provides an example of a structure whose size is well matched to the size of the cell. I will describe experiments and theory pertaining to actin cables, and the general principles of cellular self-assembly we are learning from this model system.",
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        "event_title":"EEB Tuesday Lunch Seminar - Hybrid",
        "occurrence_title":"",
        "combined_title":"EEB Tuesday Lunch Seminar - Hybrid: Rodrigo T. Figueroa, PhD student of the Museum of Paleontology and the Department of Earth and Environmental Sciences",
        "event_subtitle":"Rodrigo T. Figueroa, PhD student of the Museum of Paleontology and the Department of Earth and Environmental Sciences",
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        "event_type_id":"21",
        "description":"Our weekly lunch seminar series featuring internal speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).",
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        "datetime_modified":"20230206T120622",
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        "date_start":"2023-02-07",
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        "time_start":"12:00:00",
        "time_end":"13:00:00",
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        "event_title":"Towards Narrow-spectrum Antibiotic Discovery: Transcription and Regulation of Clostridioides difficile RNA Polymerase- Department of Biological Chemistry Seminar",
        "occurrence_title":"",
        "combined_title":"Towards Narrow-spectrum Antibiotic Discovery: Transcription and Regulation of Clostridioides difficile RNA Polymerase- Department of Biological Chemistry Seminar: Xinyun (Sherry) Cao, University of Wisconsin-Madison",
        "event_subtitle":"Xinyun (Sherry) Cao, University of Wisconsin-Madison",
        "event_type":"Workshop \/ Seminar",
        "event_type_id":"21",
        "description":"Dr. Cao will deliver a seminar on Tuesday 2\/7 at 12 noon in 3330 MS I",
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        "event_title":"DNA Nanostructures: From Design to Biological Function",
        "occurrence_title":"",
        "combined_title":"DNA Nanostructures: From Design to Biological Function: Hanadi Sleiman",
        "event_subtitle":"Hanadi Sleiman",
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        "event_type_id":"22",
        "description":"Chembio\nHanadi Sleiman",
        "occurrence_notes":null,
                "guid":"104281-21808781@events.umich.edu",
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        "id":"103058-21805784",
        "datetime_modified":"20230109T114332",
        "datetime_start":"20230208T093000",
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        "has_end_time":1,
        "date_start":"2023-02-08",
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        "event_title":"Metazoan epigenetic landscapes govern onco-genesis and divulge non-cytotoxic onco-remedies",
        "occurrence_title":"",
        "combined_title":"Metazoan epigenetic landscapes govern onco-genesis and divulge non-cytotoxic onco-remedies: Yogen Saunthararajah, M.D., Staff Physician, Professor of Medicine, Cleveland Clinic Department of Translational Hematology and Oncology Research, Lerner College of Medicine of Cleveland Clinic and Case Western Reserve University",
        "event_subtitle":"Yogen Saunthararajah, M.D., Staff Physician, Professor of Medicine, Cleveland Clinic Department of Translational Hematology and Oncology Research, Lerner College of Medicine of Cleveland Clinic and Case Western Reserve University",
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        "description":"CDB 2023 Seminar Series\r\n\r\nWe are pleased to announce that Yogen Saunthararajah, M.D. will present his talk titled \"Metazoan epigenetic landscapes govern onco-genesis and divulge non-cytotoxic onco-remedies,\" on Wednesday,  February 8, 2023, at 9:30 a.m. This will be live in ABC Conference room - BSRB and via Zoom Meeting link: https:\/\/umich.zoom.us\/s\/93126459104.\r\n\r\nHosted by:\r\nDoug Engel\r\nRami Khoriaty\r\nPavan Reddy",
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        "event_title":"Weekly DCMB Seminar with Refreshments",
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        "event_type":"Lecture \/ Discussion",
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        "description":"Abstract:\r\n\r\nMost disease associated genomic variants have relatively modest effects on target gene expression in reporter or CRISPR perturbation assays. In addition, enhancer disruption in vivo often has surprisingly weak phenotypic consequences. I will present machine learning (ML) methods (gkm-SVM and DNN) which we use to learn the complex transcription factor combinations that control enhancer activity and cell fate. I will then use these methods to develop a quantitative model for enhancer activity which shows that while promoter knockdown has robust effects on target gene expression, individual enhancer knockdown is often weaker and affects temporal transition dynamics, but not the final steady state.  This model provides an explanation of the paradox of how enhancer variation can be strongly associated with disease risk while having individually weak effects, by showing in detail how gene regulatory networks control developmentally important and disease relevant cell state transitions and cancer.\r\n\r\nhttps:\/\/umich-health.zoom.us\/j\/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09",
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