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        "datetime_modified":"20230316T084737",
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        "date_end":"2023-04-11",
        "time_start":"16:00:00",
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        "time_zone":"America\/Detroit",
        "event_title":"Functional MRI Speaker Series",
        "occurrence_title":"",
        "combined_title":"Functional MRI Speaker Series: with Dr. Lirong Yan",
        "event_subtitle":"with Dr. Lirong Yan",
        "event_type":"Lecture \/ Discussion",
        "event_type_id":"13",
        "description":"Title: Arterial Spin Labeling in Neurovascular Imaging: Beyond CBF\r\n\r\nAbstract: Arterial spin labeling (ASL) is a non-invasive MRI technique for measuring cerebral blood flow. Over the past three decades, ASL has undergone rapid technical development, which promotes ASL to become a useful imaging tool for brain perfusion measurement. Except for ASL perfusion imaging, additional physiological information can be derived using ASL during the passage of labeled blood through the cerebral arterial trees into capillaries and tissue, such as dynamic MR angiography, vascular territorial mapping, and other hemodynamic parameter quantification, all of which could also provide useful information in neurovascular applications. In this talk, I will start with a brief overview of ASL technical development, then move on to introduce our recent research in advanced ASL development.\r\n\r\n\r\n\r\n\r\n*Light refreshments will be served.\r\n*Please take the Church St. elevator to the 4th floor.",
        "occurrence_notes":"Please take the Church St. elevator to the 4th floor.",
                "guid":"106284-21814022@events.umich.edu",
        "permalink":"http:\/\/events.umich.edu\/event\/106284",
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        "building_name":"East Hall",
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        "tags":["Biosciences"],
        "website":"https:\/\/nittlab.fsm.northwestern.edu\/",
        "links":[
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                "url":"https:\/\/nittlab.fsm.northwestern.edu\/",
                "title":"NITT Lab"
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                "url":"https:\/\/www.feinberg.northwestern.edu\/faculty-profiles\/az\/profile.html?xid=54934",
                "title":"Northwestern Medicine, Yan"
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                "url":"http:\/\/fmri.research.umich.edu\/",
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        "event_title":"Investigating Nanostructure Synthesis Using In Situ TEM",
        "occurrence_title":"",
        "combined_title":"Investigating Nanostructure Synthesis Using In Situ TEM: Beth Guiton (University of Kentucky)",
        "event_subtitle":"Beth Guiton (University of Kentucky)",
        "event_type":"Other",
        "event_type_id":"22",
        "description":"Understanding the fundamental relationship between atomic structure and material properties is the holy grail of materials sciences. Towards this goal we are working to develop a real-time and atomistic understanding of the mechanistic steps taken during the growth and transformation of crystalline materials. To do this we employ a combination of complementary synthetic and characterization approaches, in particular using in situ ultra-high resolution transmission electron microscopy (TEM) to observe key structural transformations in real-time. Our in situ experiments include directly performing nanomaterial synthesis in the TEM, as well as determining the kinetics of structural phase transformations of as-synthesized inorganic nanocrystals. Further, based on an unexpected observation made during one of these in situ measurements, we have developed a new approach to directly synthesize arrays of crystallographically well-defined nanoscale interfaces. Several examples will be presented to illustrate our approach, including: the real-time observation of the solid-state synthesis of an individual nanocapsule; a post-synthetic structural phase transformation within an individual nanorod; and finally, the creation of new nanostructured architectures using liquid metal nanodroplets.                                             \nBeth Guiton (University of Kentucky)",
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    ,        {
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        "datetime_modified":"20230323T140235",
        "datetime_start":"20230412T093000",
        "datetime_end":"20230412T103000",
        "has_end_time":1,
        "date_start":"2023-04-12",
        "date_end":"2023-04-12",
        "time_start":"09:30:00",
        "time_end":"10:30:00",
        "time_zone":"America\/Detroit",
        "event_title":"Strategies for Promoting and Sustaining Gender and Racial Equity for Faculty in STEM Disciplines",
        "occurrence_title":"",
        "combined_title":"Strategies for Promoting and Sustaining Gender and Racial Equity for Faculty in STEM Disciplines: Ellen Broido, D.Ed. - Professor of Higher Education & Student Affairs, College of Education & Human Development, Bowling Green State University",
        "event_subtitle":"Ellen Broido, D.Ed. - Professor of Higher Education & Student Affairs, College of Education & Human Development, Bowling Green State University",
        "event_type":"Lecture \/ Discussion",
        "event_type_id":"13",
        "description":"CDB Seminar Series\r\n\r\nWe are pleased to announce that Ellen Broido, D.Ed. will present her talk titled \"Strategies for Promoting and Sustaining Gender and Racial Equity for Faculty in STEM Disciplines,\" on Wednesday, April 12, 2023, at 9:30 a.m. This will be live in ABC Conference room - BSRB and via Zoom Meeting link: https:\/\/umich.zoom.us\/s\/93126459104.\r\n\r\nHosted by:  CDB Students",
        "occurrence_notes":"BSRB ABC Conference rooms and Zoom Meeting link: https:\/\/umich.zoom.us\/s\/93126459104.",
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        "datetime_modified":"20230404T091553",
        "datetime_start":"20230412T160000",
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        "has_end_time":1,
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        "time_zone":"America\/Detroit",
        "event_title":"DCMB \/ CCMB   Weekly Seminar",
        "occurrence_title":"",
        "combined_title":"DCMB \/ CCMB   Weekly Seminar: Tomer Stern, PhD (Asst. Prof., Dentistry, Department of Biologic and Materials Sciences, School of Dentistry)",
        "event_subtitle":"Tomer Stern, PhD (Asst. Prof., Dentistry, Department of Biologic and Materials Sciences, School of Dentistry)",
        "event_type":"Lecture \/ Discussion",
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        "description":"Abstract:\r\n\r\nFrom the initial genetic patterning to the assembly of the whole embryo, how ordered structures form has always been a fundamental question in developmental biology. The recent advances in imaging technologies are now providing us with direct visual access to the development of whole organisms in unprecedented detail. However, it is clear that to make the best use of this complex data, we need the help of computer algorithms that can mine it for biologically relevant information, summarize and then visualize it for us. The first project I will present focuses on the mechanisms driving the development of diverse 3D bone morphologies in mice. There, we developed algorithms to analyze micro-CT images to deconstruct the final morphology of each bone into the contributions made by remodeling of mineralized tissue vs. the cartilaginous growth plates. This allowed us to demonstrate the central role of the growth plate in 3D bone morphogenesis in normal and pathological development. The second project aims to understand how different cell activities contribute to large-scale morphogenetic movements. To this end, we generated the first whole embryo single-cell atlas of morphogenetic activity underlying gastrulation in the fruit fly, then used these maps to derive a statistical model associating cell shape changes and rearrangements to body axis elongation.\r\n\r\nhttps:\/\/umich-health.zoom.us\/j\/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09\r\n\r\nAreas of Interest:\r\n\r\nMy lab focuses on understanding how cells organize to form various tissue morphologies during normal and pathological development. We use two model systems to achieve this: the musculoskeletal system in mice and whole embryo development in fruit flies. Our approach centers on the development of cutting-edge bioimage informatics and data science algorithms to analyze the dynamics and the underlying patterns in developing tissues through 3D and 4D (3D+time) fluorescence images.",
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                "title":"CCMB Affiliate, Tomer Stern"
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        "id":"101181-21800914",
        "datetime_modified":"20230412T181509",
        "datetime_start":"20230412T160000",
        "datetime_end":"20230412T173000",
        "has_end_time":1,
        "date_start":"2023-04-12",
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        "time_start":"16:00:00",
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        "time_zone":"America\/Detroit",
        "event_title":"The role of Cytochrome P450 Metabolism of Dietary Fatty Acids on Neurodegeneration\r\n",
        "occurrence_title":"",
        "combined_title":"The role of Cytochrome P450 Metabolism of Dietary Fatty Acids on Neurodegeneration\r\n: Kin Sing Stephen Lee (Michigan State University)",
        "event_subtitle":"Kin Sing Stephen Lee (Michigan State University)",
        "event_type":"Other",
        "event_type_id":"22",
        "description":"Despite decades of research, the mechanism of neurodegeneration remains unclear. Ferroptosis, a non-apoptotic programmed cell death driven by an iron-dependent membrane lipid peroxidation, is an emerging target and mechanism for aging and age-associated neurodegenerative diseases. While membrane lipid peroxidation is one of the molecular hallmarks of ferroptosis, the involvement of specific polyunsaturated fatty acids and their downstream metabolites as endogenous lipid mediators of ferroptosis remains understudied. Here, we hypothesize that cytochrome P450 (CYP)-epoxide hydrolases metabolites of PUFAs are a new class of lipid mediators of ferroptosis. \\r\\nInvestigating the effects of specific PUFA and PUFA metabolites on ferroptosis are challenging for two main reasons. Firstly, there is a plethora of endogenous biosynthetic and metabolic enzymatic pathways, and these enzymes express differently across diverse tissues. Secondly, the mechanism of ferroptosis is not well-defined or characterized. Therefore, a system approach is likely needed. To overcome these challenges, we employed Caenorhabditis elegans (C. elegans) as a novel simplified biological model. Using a well-established neurodegenerative assay and transgenic C. elegans with green-fluorescent protein-tagged (GFP) neurons, we show that among all the tested PUFAs, only dihomo-gamma-linolenic acid (DGLA) triggers significant ferroptosis-mediated neurodegeneration after one day of exposure. Interestingly, only dopaminergic neurons and, to a lesser extent, glutaminergic neurons were affected in our studies. Using our state-of-the-art oxylipins analysis and comprehensive chemical probes, we identified the dihydroxy- metabolites of DGLA are likely the lipid mediator responsible for DGLA-induced ferroptosis-mediated neurodegeneration. We were also able to show that epoxide hydrolases play a key role in ferroptosis and neurodegeneration. \\r\\nIn short, our study identified a novel class of endogenous lipid mediators of ferroptosis. Our findings improve our understanding of how PUFA downstream metabolism modulates neurodegeneration.  Additionally, the developed C. elegans models and identified dihydroxy- metabolites of DGLA provide a strong foundation for us to further investigate the mechanism of ferroptosis-mediated neurodegeneration that would identify a novel mechanism for ferroptosis and novel therapeutic targets for preventative or disease-altering treatments for neurodegenerative diseases. At the end of this presentation, we will also share the current drug discovery effort to target this metabolism for neurodegenerative diseases.                                            \r\n                        \nKin Sing Stephen Lee (Michigan State University)",
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        "datetime_modified":"20230316T180011",
        "datetime_start":"20230413T100000",
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        "has_end_time":1,
        "date_start":"2023-04-13",
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        "time_start":"10:00:00",
        "time_end":"11:00:00",
        "time_zone":"America\/Detroit",
        "event_title":"MCDB Seminar> From Development to Aging: a Single-Cell Sequencing Journey in Drosophila Fruit Fly",
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        "combined_title":"MCDB Seminar> From Development to Aging: a Single-Cell Sequencing Journey in Drosophila Fruit Fly: Hongjie Li, Baylor College of Medicine",
        "event_subtitle":"Hongjie Li, Baylor College of Medicine",
        "event_type":"Workshop \/ Seminar",
        "event_type_id":"21",
        "description":"Sponsored by MCDB and Life Sciences Institute\r\nHost: Laura Buttitta, MCDB",
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                "website":""                },             {
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        "id":"102029-21803373",
        "datetime_modified":"20230330T131828",
        "datetime_start":"20230413T110000",
        "datetime_end":"20230413T130000",
        "has_end_time":1,
        "date_start":"2023-04-13",
        "date_end":"2023-04-13",
        "time_start":"11:00:00",
        "time_end":"13:00:00",
        "time_zone":"America\/Detroit",
        "event_title":"Winter 2024 Study Abroad Advising with CGIS",
        "occurrence_title":"",
        "combined_title":"Winter 2024 Study Abroad Advising with CGIS",
        "event_subtitle":"",
        "event_type":"Fair \/ Festival",
        "event_type_id":"10",
        "description":"Are you thinking of study abroad during the winter term but have questions?\r\n\r\nPop in to the CGIS office on April 13th any time between 11am and 1pm for open advising on Winter 2024 study abroad options with CGIS!\r\n\r\nWe can answer questions about Winter 2024 programs, the application process, scholarships and financial aid, and more! Come learn more about major-specific programs such as programs in the environment, Spanish, and Humanities\/Social Sciences, and interest-specific program sessions, such as studying abroad in the UK and English-taught programs in Asia, to name a few. \r\n*LSA Scholarships, the Office of Financial Aid, and Newnan will also be in attendance.*\r\n\r\nPopcorn will be provided!",
        "occurrence_notes":"Visit the CGIS Office to get started!",
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        "event_title":"LSI Seminar Series: Minoree Kohwi, Ph.D., Columbia University, Zuckerman Institute Mind Brain Behavior",
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        "datetime_modified":"20230411T104610",
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        "event_title":"Responsible Data Science and AI mini-symposium",
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        "description":"Data science and AI are having a significant impact on society in uncountable ways, leading to huge benefits in many cases. Yet, increasingly complex analytical pipelines working with poorly understood heterogeneous data sets can give rise to harm in many ways. Furthermore, there could be deleterious systemic effects such as the magnification of disinformation or surveillance capitalism. There has been tremendous recent interest in understanding and managing these concerns.\r\n\r\nThis mini-symposium is part of the Future Leader Summit program, a three-day event which brings together outstanding graduate students and postdocs from around the US to engage in research discussions with peers and with research leaders, and receive career mentoring, as they grow to become future research leaders in data science and Artificial Intelligence (AI).\r\n\r\nFree and open to the public. \r\nRegister here: https:\/\/forms.gle\/tcAW9ER5WsCMcTLS7\r\n\r\n---\r\n\r\n\"Human-machine partnership for conservation: AI and humans combatting extinction together\"\r\nTanya Berger-Wolf, Director, Translational Data Analytics Institute, The Ohio State University\r\n\r\n\"From interstellar rocks to dark energy: building data science across research communities\"\r\nAndrew Connolly, Director, eScience Institute, University of Washington\r\n\r\n\"Equity in Data Science\" \r\nH. V. Jagadish, Director, MIDAS, University of Michigan\r\n\r\n\"Building a culture of Responsible AI (and what it means for researchers)\"\r\nEllie Sakhaee, Senior Program Manager, Office of Responsible AI, Microsoft",
        "occurrence_notes":null,
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        "id":"107535-21816174",
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        "datetime_start":"20230413T140000",
        "datetime_end":"20230413T150000",
        "has_end_time":1,
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        "time_start":"14:00:00",
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        "time_zone":"America\/Detroit",
        "event_title":"Here Comes the Sun",
        "occurrence_title":"",
        "combined_title":"Here Comes the Sun: NeuroNetwork for Emerging Therapies Mini Symposium Series",
        "event_subtitle":"NeuroNetwork for Emerging Therapies Mini Symposium Series",
        "event_type":"Livestream \/ Virtual",
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        "description":"Hellen Keller once remarked that if you \u201ckeep your face in the sun, you will never see the shadows.\u201d  \r\n\r\nThankfully we are headed into the warmer months when it is much easier to capture those magical rays and the benefits that come along with them. Most people know that more sun means an increase in that much-needed vitamin D, as well as an increase in serotonin. Did you know that sunshine has been found to also affect cognition? Or, that it can actually help certain skin conditions?\r\n\r\nIt\u2019s true that the sun boasts quite an impressive list of benefits, but as the age-old saying goes: \u201cYou don\u2019t want too much of a good thing.\u201d The first description of skin cancer dates as far back as the writings of Hippocrates of Kos in the 5th century, B.C. However, scientists at Michigan Medicine, led by one of our mini symposium speakers, are still connecting UV rays with new unexpected forms of cancer.\r\n\r\nIt is hard to know where to dive into the massive amount of health-related information revolving around the sun. However, \u201cHere Comes the Sun,\u201d the next installment of the NeuroNetwork for Emerging Therapies Mini Symposium Series, on Thursday, April 27, at 2 PM ET via Zoom, is a great place to start.  \r\n\r\nThe event is presented by the Wolfe Brain Health Initiative,  in partnership with the Frances and Kenneth Eisenberg Family Depression Center,  the Department of Psychiatry, and the Department of Dermatology.\r\n\r\nWe are extremely excited to welcome the speakers below.\r\n\r\nAs sure as the sun comes up each day (we couldn\u2019t resist\u2014sorry), this is an event you don\u2019t want to miss. Don't forget to submit your questions when you register.\r\n\r\nThe Sun & Brain Health + Moderator\r\nEva Feldman, MD, PhD\r\nJames W. Albers Distinguished University Professor of Neurology\r\nRussell N. DeJong Professor of Neurology\r\nDirector, NeuroNetwork for Emerging Therapies\r\n\r\nThe Sun & Seasonal Affective Disorder\r\nLeslie Swanson, PhD\r\nClinical Associate Professor\r\nDepartment of Psychiatry\r\nEisenberg Family Depression Center\r\n\r\nThe Dos & Don'ts of Sun Exposure & Your Skin\r\nKelly L. Harms, MD, PhD\r\nLewis and Lillian Becker Professor of Dermatology\r\nChief, Division of Cutaneous Surgery and Oncology",
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